CEACAM6-high airway neutrophils and epithelial cells are a feature of severe asthma

Aarti Parmar (Leicester, United Kingdom), Aarti Shikotra, David Choy, Salman Siddiqui, Greer Arthur, Deepti Nagarkar, Jia Guiquan, Chandra Ohri, Emma Doran, Claire Butler, Beverley Hargadon, Alexander Abbas, Janet Jackman, Lawren Wu, Liam Heaney, Joe Arron, Peter Bradding

Source: International Congress 2015 – Translational studies in airway cell biology
Session: Translational studies in airway cell biology
Session type: Thematic Poster Session
Number: 910
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Aarti Parmar (Leicester, United Kingdom), Aarti Shikotra, David Choy, Salman Siddiqui, Greer Arthur, Deepti Nagarkar, Jia Guiquan, Chandra Ohri, Emma Doran, Claire Butler, Beverley Hargadon, Alexander Abbas, Janet Jackman, Lawren Wu, Liam Heaney, Joe Arron, Peter Bradding. CEACAM6-high airway neutrophils and epithelial cells are a feature of severe asthma. Eur Respir J 2015; 46: Suppl. 59, 910

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Human lung mast cells alter asthmatic airway epithelial cell function
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


Human mast cells and type 2 innate lymphoid cells activate gene expression and mucus composition in human bronchial epithelial cells via IL-13
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014

Enhanced inflammatory gene expression in bronchial epithelial cells from asthmatic patients: Attenuation by a Brd4 mimic
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Differential expression of uPAR in cultured bronchial epithelial cells from asthma patients
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Imbalance of immune response functional phenotype and alveolar macrophages phenotype in COPD
Source: International Congress 2014 – New insights into monocyte and macrophage biology
Year: 2014


IgA expression in peribronchial and lung follicular B cells from COPD patients
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016


The role of chemokine receptors in the aberrant migration of COPD neutrophils
Source: International Congress 2014 – Cell biology 2014
Year: 2014

COPD airway epithelium secretion attracts and activates neutrophils
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

B cells in a murine model of allergic asthma and respiratory tolerance
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Regulation of GROα production in human bronchial epithelial cells
Source: International Congress 2016 – Laboratory tests and cell biology in allergy and immunology
Year: 2016


Expression of CX3CL1 and CX3CR1 in human asthmatic lung in relation to cell survival
Source: International Congress 2014 – New mechanisms in the pathogenesis of asthma and other lung diseases
Year: 2014

Evidence for a novel kit adhesion domain mediating human mast cell adhesion to structural airway cells
Source: International Congress 2014 – Cell biology 2014
Year: 2014

The capacity of human airway epithelium to regulate T cell proliferation is reduced in asthma
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

MIP-1β is associated with eosinophilic airway inflammation
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016


TNF-a induces cPLA2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014


S100 proteins induce MUC5AC production in airway epithelial cells
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014

Airway epithelial cells from asthmatic adults support elevated human metapneumovirus infection due to impaired apoptosis
Source: International Congress 2015 – Advances from translational research in respiratory infections
Year: 2015


Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by cytotoxic/ pro-inflammatory lymphocytes
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Disturbed pulmonary immunity and the phenotype of alveolar macrophages in bronchial asthma, gastroesophageal reflux disease and their combination
Source: International Congress 2014 – New insights into monocyte and macrophage biology
Year: 2014

Reconstituted human airway epithelium 3D-model to assess the impact of air pollutants on the inflammatory response
Source: International Congress 2014 – Mechanistic studies of the airway epithelium
Year: 2014