Transforming growth factor alpha increases extracellular matrix within the airway smooth muscle layer in a transgenic mouse model of airway disease

John Elliot (Perth, Australia), John Elliot, Alan James, Kimberley Wang, Alexander Larcombe, Graeme Zosky, Timothy Le Cras, Peter Noble

Source: International Congress 2015 – Airway remodelling: recent developments
Session: Airway remodelling: recent developments
Session type: Thematic Poster Session
Number: 894
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
John Elliot (Perth, Australia), John Elliot, Alan James, Kimberley Wang, Alexander Larcombe, Graeme Zosky, Timothy Le Cras, Peter Noble. Transforming growth factor alpha increases extracellular matrix within the airway smooth muscle layer in a transgenic mouse model of airway disease. Eur Respir J 2015; 46: Suppl. 59, 894

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Extracellular matrix within the airway smooth muscle layer correlates with age but not in cases of asthma
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016

FGF-2 modulates human airway smooth muscle contractile protein expression and cell stiffness
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Upregulation of nerve growth factor expression by human airway smooth muscle cells in inflammatory conditions
Source: Eur Respir J 2002; 20: 458-463
Year: 2002



The extracellular matrix deposited by asthmatic airway smooth muscle cells in a resting state reflects a healthy matrix
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015


TGF-beta alters TRPC6 expression and calcium handling via smad2/3 in human airway smooth muscle
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013


The effect of adenosine on VEGF release from airway smooth muscle from subjects with asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

MNK-1 inhibition reduces proliferation and CXCL10 in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Targeting ASK1 in preventing airway smooth muscle growth: Implications for airway remodeling in COPD
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016


IL33 and TNFalpha synergistically enhance store operated Ca2+ entry in cultured human airway smooth muscle cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013


Endothelin receptor B protects GM-CSF mRNA from degradation in human airway smooth muscle cells
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Regulation of actin dynamics by WNT-5A: Implications for human airway smooth muscle contraction
Source: International Congress 2016 – Studies in airway cell biology
Year: 2016


A functional role for WNT-5A in driving airway myocyte proliferation
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013


Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Eosinophil-induced airway smooth muscle cells remodeling is attenuated by blocking of RGD-binding integrins in asthma
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016

Airway smooth muscle contractility is increased following coculture with fibrocytes
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration
Source: International Congress 2014 – Cell biology 2014
Year: 2014


The effect of JQ1/SGCBD01 upon c-Myc in human airway smooth muscle in asthma
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Upregulation of airway smooth muscle (ASM) cell apoptosis may limit ASM growth during airway remodeling in experimental asthma
Source: Annual Congress 2008 - Novel mechanisms in the pathogenesis of pulmonary inflammation
Year: 2008

Link between airway inflammation and remodeling: TNFα induces airway smooth muscle cell proliferation via an ET1/GMCSF/IL6 network
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015