PDE isozymes and effects of selective PDE inhibitors on human lung fibroblasts (Fbs)

F. Sabatini, L. Petecchia, M. Silvestri, L. Serpero, S. Boero, G. A. Rossi (Genoa, Italy)

Source: Annual Congress 2005 - Pulmonary fibrosis and pleural disease
Session: Pulmonary fibrosis and pleural disease
Session type: Thematic Poster Session
Number: 3556
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Sabatini, L. Petecchia, M. Silvestri, L. Serpero, S. Boero, G. A. Rossi (Genoa, Italy). PDE isozymes and effects of selective PDE inhibitors on human lung fibroblasts (Fbs). Eur Respir J 2005; 26: Suppl. 49, 3556

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Efficacy of the selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in a rat model of neutrophilic lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

The phosphodiesterase 4 inhibitor SB 207499 selectively inhibits neutrophil functions
Source: Eur Respir J 2001; 18: Suppl. 33, 34s
Year: 2001

Phosphodiesterase expression and activity in human airways
Source: Eur Respir J 2004; 24: Suppl. 48, 21s
Year: 2004

The selective phosphodiesterase 4 inhibitor, cilomilast, inhibits interleukin-8-induced pulmonary neutrophil accumulation in the rabbit
Source: Eur Respir J 2001; 18: Suppl. 33, 35s
Year: 2001

The PDE4 inhibitor roflumilast N-oxide partly reversed TGFß1-induced changes in collagen I and E-cadherin expression in human airway epithelial cells
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD
Year: 2008

COX inhibition enhances remodelling processes in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

The combination of PDE4 and PDE5 inhibitors reduces YAP expression in IPF
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Effects of CHF6297, a potent and selective p38a MAPK inhibitor, in murine models of steroid resistant lung inflammation
Source: International Congress 2017 – Towards new anti-inflammatory and anti-fibrotic agents
Year: 2017



Effects of PDE4 inhibitors on eotaxin-3 (CCL26) expression in lung epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
Source: International Congress 2019 – Advances in asthma pharmacology
Year: 2019


A selective phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in guinea-pig antigen challenge and ferret emesis models
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

The mechanism of plasminogen activator inhibitor type-1 (PAI-1) Cys mutants inhibitory activity towards lung capillaries endothelial cells (HMVEC-L)
Source: Eur Respir J 2005; 26: Suppl. 49, 93s
Year: 2005

Molecular and cellular profile of the structurally novel phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

Proapoptotic and anti-proliferative effect of the stable plasminogen activator inhibitor type 1 (PAI-1) mutant on the lung cancer and endothelial cells
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Effects of a selective phosphodiesterase IV and V inhibitor in a murine model of chronic asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

The effect of an oral phosphodiesterase (PDE) 4 inhibitor, BAY 19-8004, in primate asthma models
Source: Eur Respir J 2001; 18: Suppl. 33, 36s
Year: 2001

PP110 – Modulation of the TGF-ß-induced epithelial-to-mesenchymal transition by panselective PDE inhibitors in A549 cells
Source: ERS Lung Science Conference 2021
Year: 2021

Effect of phosphodiesterase 4 (PDE-4) inhibitor – rolipram with or without co-administration of dexamethasone on experimental asthma - guinea pig model
Source: Eur Respir J 2004; 24: Suppl. 48, 128s
Year: 2004

Roflumilast N-oxide (RNO) increases MAP kinase phosphatase-1 (MKP-1) expression in human lung fibroblasts (HLF)
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010

Muscarinic receptors mediate stimulation of collagen synthesis in human lung fibroblasts
Source: Eur Respir J 2008; 32: 555-562
Year: 2008