Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells

de Vries Maaike, Smithers Natalie P., Howarth Peter H., Nawijn Martijn C., Davies Donna E.

Source: Eur Respir J 2015; 45: 1745-1748
Journal Issue: June
Disease area: Airway diseases

Full text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
de Vries Maaike, Smithers Natalie P., Howarth Peter H., Nawijn Martijn C., Davies Donna E.. Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells. Eur Respir J 2015; 45: 1745-1748

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The inhibition of fas-mediated apoptosis of lung alveolar epithelial cells by cyclin dependent kinase inhibitor p21
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

Protective effect of MAPK inhibitors and budesonide against apoptosis induced by TGF-β in primary cultures of human bronchial epithelial cells
Source: Eur Respir J 2003; 22: Suppl. 45, 394s
Year: 2003

Induction of apoptosis in murine alveolar epithelial cells by a proteasome inhibitor
Source: Eur Respir J 2001; 18: Suppl. 33, 358s
Year: 2001

Effects of MAPK inhibitors on H2O2-induced IL-8 production and cell death in primary cultures of human bronchial epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 218s
Year: 2004

Adenovirus E1A suppressed elafin secretion in human bronchial epithelial cells and alveolar epithelial cells
Source: Eur Respir J 2004; 24: Suppl. 48, 554s
Year: 2004

MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

Protein kinase C and mitochondrial signaling mediate PM10-induced ROS and TGF-β expression in the bronchial epithelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 574s
Year: 2007

The NS1A binding protein in alveolar epithelial cells as centerpiece of Influenza virus A lung injury mechanism mediated via AhR/Arnt signaling pathway
Source: International Congress 2017 – Anti-inflammatory and pro-repair mediators in acute lung injury
Year: 2017

Effects of respiratory syncytial virus and adenovirus infection in cytokine expression and nuclear factor-κB activation human bronchial epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 192s
Year: 2006

Rhinovirus up-regulates toll-like receptor 3 on bronchial epithelial cells and is dependent on viral replication
Source: Annual Congress 2004 - Mechanisms and treatment of virus induced asthma exacerbations
Year: 2004


Inhibition of CFTR-specific miRNAs in CF bronchial epithelial cells
Source: International Congress 2017 – Therapeutic approaches in lung disease
Year: 2017


Interleukin-8 stimulates human airway epithelial cell proliferation through EGFR transactivation
Source: Eur Respir J 2003; 22: Suppl. 45, 561s
Year: 2003

Involvement of NFkB activation and c-JUN phosphorylation in bronchial epithelial cells by CD-40-CD40L pathway
Source: Eur Respir J 2002; 20: Suppl. 38, 573s
Year: 2002

Inhibition of IRAK4 suppresses chemokine release from human bronchial epithelial cells
Source: Annual Congress 2013 –Molecular biology: state-of-the-art 2013
Year: 2013

Potential role of filamin and p38 MAPK in the regulation of human alveolar epithelial cell permeability
Source: Eur Respir J 2002; 20: Suppl. 38, 96s
Year: 2002

Effect of endothelin on DNA synthesis in human bronchial eipthelial cells: role of MAPK cascade
Source: Eur Respir J 2001; 18: Suppl. 33, 476s
Year: 2001

Effects of TGF-beta and budesonide on MAPK phosphorylation, IL-6/IL-11 secretion, and cell proliferation in human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 662s
Year: 2006

Secretory leucoprotease inhibitor (SLPI) inhibits IL-8 expression induced by double-stranded RNA in airway epithelial cells
Source: Annual Congress 2008 - Airway cell biology
Year: 2008


Modulation of cadherin and catenin expression and apoptosis in human bronchial epithelial cells
Source: Eur Respir J 2001; 18: Suppl. 33, 353s
Year: 2001

Novel narrow spectrum kinase inhibitors inhibit rhinovirus replication via enhancement of interferon expression in nasal epithelial cells of atopic and non-atopic patients
Source: Annual Congress 2011 - Insight into mechanisms of respiratory infections
Year: 2011