Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition

Gohy Sophie T., Hupin Cloé, Fregimilicka Chantal, Detry Bruno R., Bouzin Caroline, Gaide Chevronay Héloïse, Lecocq Marylène, Weynand Birgit, Ladjemi Maha Z., Pierreux Christophe E., Birembaut Philippe, Polette Myriam, Pilette Charles

Source: Eur Respir J 2015; 45: 1258-1272
Journal Issue: May
Disease area: Airway diseases

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Gohy Sophie T., Hupin Cloé, Fregimilicka Chantal, Detry Bruno R., Bouzin Caroline, Gaide Chevronay Héloïse, Lecocq Marylène, Weynand Birgit, Ladjemi Maha Z., Pierreux Christophe E., Birembaut Philippe, Polette Myriam, Pilette Charles. Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition. Eur Respir J 2015; 45: 1258-1272

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The role of epithelial to mesenchymal transition (EMT) in airway remodelling after human lung transplantation
Source: Annual Congress 2008 - Vascular and interstitial remodelling in chronic lung disease: therapeutic interventions on the horizon
Year: 2008

Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
Source: Eur Respir Rev 2014; 23: 118-130
Year: 2014



Epithelial mesenchymal transition (EMT) related changes in small airways of smokers and patients with COPD
Source: Virtual Congress 2021 – Pathogenic progress in airway diseases
Year: 2021


PP206 – Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: ERS Lung Science Conference 2021
Year: 2021

Altered airway epithelial cell specification in COPD
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015


Epithelial to mesenchymal transition in basal progenitor epithelial cells cultured from smokers and COPD patients
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015


Bronchial epithelial mesenchymal transition (EMT) results is in up-regulation of endothelin-1
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Epithelial mesenchymal transition in lung allografts
Source: Eur Respir J 2004; 24: Suppl. 48, 180s
Year: 2004

Interleukin-1alpha drives the dysfunctional cross-talk of the airway epithelium and lung fibroblasts in COPD
Source: Eur Respir J 2016; 48: 359-369
Year: 2016



Endothelial to mesenchymal transition (EnMT) as a mechanism of alveolar septal fibrosis/remodelling in emphysema
Source: Annual Congress 2009 - Bronchoalveolar lavage and phenotyping in diffuse parenchymal lung disease
Year: 2009

COPD-related epithelial inflammation drives EMT in primary epithelial ALI-cultures
Source: International Congress 2018 – COPD: immune regulation and therapeutic targets
Year: 2018


LSC - 2021 - Modeling idiopathic pulmonary fibrosis using induced pluripotent stem cell-derived alveolar epithelial organoids
Source: Virtual Congress 2021 – In vitro modelling of lung disease: reach out to the next dimension
Year: 2021


Investigating large and small airway epithelial cell senescence in COPD and bronchiectasis
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Altered phenotype of COPD primary fibroblasts from airway and alveolar tissues: proliferation and apoptosis.
Source: International Congress 2019 – Research and innovation in airway diseases
Year: 2019

Oral presentation: Epithelial-mesenchymal transition occurs in undifferentiated basal bronchial epithelial cells in normal and asthmatic subjects
Source: Lung Science Conference 2009 - Cell proliferation, Differentiation and Carcinogenesis
Year: 2009



Interaction between epithelial cells and sub-epithelial mesenchymal cells in severe non-allergic asthma
Source: International Congress 2019 – Pathophysiology and clinical insights into severe non-allergic asthma
Year: 2019


Supervising differentiation for tailoring the airway epithelial cell phenotype
Source: International Congress 2018 – COPD: novel pathological mechanisms in the airway epithelium
Year: 2018

Epithelial mesenchymal transition (EMT) in small and large airways of smokers; and relation to airflow obstruction
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

TGFβ-induced epithelial to mesenchymal transition (EMT) as a model of COPD
Source: International Congress 2016 – Novel insights into alveolar and bronchial epithelial cell injury and repair
Year: 2016