Chronic intermittent hypoxia induces features of non alcoholic fatty liver disease (NAFLD) and modifies adipose tissue characteristics in lean mice

J. Aron-Wisnewsky, E. Gras, A. Thomas, D. Godin-Ribuot, K. Clement, J. L. Pepin (Paris, La Tronche, Grenoble Cedex 09, France)

Source: International Congress 2014 – Inflammation and obesity: implications for OSA
Session: Inflammation and obesity: implications for OSA
Session type: Oral Presentation
Number: 4445

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Aron-Wisnewsky, E. Gras, A. Thomas, D. Godin-Ribuot, K. Clement, J. L. Pepin (Paris, La Tronche, Grenoble Cedex 09, France). Chronic intermittent hypoxia induces features of non alcoholic fatty liver disease (NAFLD) and modifies adipose tissue characteristics in lean mice. Eur Respir J 2014; 44: Suppl. 58, 4445

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The effect of chronic intermittent hypoxia on hepatic injury and mechanism in lean mice and mice with diet-induced obesity
Source: International Congress 2014 – Of mice and men: physiology and biology of sleep disordered breathing
Year: 2014


Chronic intermittent hypoxia induces liver injury in mice with diet induced obesity via TLR4/MyD88/MAPK/NF-kB signaling pathways
Source: International Congress 2016 – Hypoxia, oxidative stress, and biomarkers in obstructive sleep apnoea
Year: 2016

Significant associations between obstructive sleep apnea and fat accumulation in the liver in male subjects without visceral obesity
Source: Annual Congress 2013 –A metabolic medley: sleep disordered breathing
Year: 2013

The influence of obstructive sleep apneao–induced  intermittant Hypoxia on Non Alcoholic  Fatty  liver.
Source: International Congress 2017 – Pathophysiological aspects of comorbid conditions in obstructive sleep apnoea
Year: 2017

Brain oxidative stress induced by recurrent obstructive apneas: Old versus young rats
Source: Annual Congress 2013 –Heart, blood and metabolism in sleep disordered breathing
Year: 2013

Impacts of long-term CPAP therapy on fatty liver in male OSA patients with abdominal obesity
Source: International Congress 2014 – Real or not? The impact of OSA and CPAP on comorbid conditions
Year: 2014

CPAP treatment: effects on plasma lipids and liver function
Source: Research Seminar 2009 - Intermittent hypoxia and adipose tissue - Insight into the pathophysiology of the Obstructive Sleep Apnoea Syndrome (OSAS) and treatment options
Year: 2009


In sleep apnea patients nonalcoholic fatty liver disease (NAFLD) is associated with the severity of intermittent hypoxia and more severe endothelial dysfunction
Source: Annual Congress 2012 - Sleep disorders in internal medicine
Year: 2012


Does sleep loss play a role in adipose tissue dysfunction?
Source: Research Seminar 2009 - Intermittent hypoxia and adipose tissue - Insight into the pathophysiology of the Obstructive Sleep Apnoea Syndrome (OSAS) and treatment options
Year: 2009

Inflammation in obese adipose tissue
Source: Research Seminar 2009 - Intermittent hypoxia and adipose tissue - Insight into the pathophysiology of the Obstructive Sleep Apnoea Syndrome (OSAS) and treatment options
Year: 2009


Hypertension induced by chronic intermittent hypoxia: Effects of carvedilol in a rat model
Source: International Congress 2015 – A bout de souffle: hypoxia and sleep-disordered breathing
Year: 2015



Chronic intermittent hypoxia reduces progressive sperm motility in a mouse model of obstructive sleep apnea
Source: Annual Congress 2013 –Of mice and men: sleep disordered breathing
Year: 2013

Effects of obstructive sleep apnoea on systemic inflammation and adipose tissue expression of CD40, MKK4 and JNK
Source: International Congress 2014 – Inflammation and obesity: implications for OSA
Year: 2014



Effect of CPAP treatment on endothelial function, inflammatory markers, blood pressure and glucose control in male and female patients with OSAS
Source: International Congress 2014 – Sleep disordered breathing 3
Year: 2014

Obesity and chronic intermittent hypoxia are independent risk factors for clinical decompensation in patients with cirrhosis and OSAS
Source: International Congress 2014 – Inflammation and obesity: implications for OSA
Year: 2014


Effects of normoxic recovery on intermittent hypoxia-induced changes of microbiome in a mouse model of OSA
Source: International Congress 2016 – Effects of hypoxia and sleep apnoea on the lung, heart, and vessels
Year: 2016

Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease
Source: Annual Congress 2011 - Physiology and cardiometabolic comorbidities in obstructive sleep apnoea
Year: 2011


Association between obstructive sleep apnea and the severity of non-alcoholic fatty liver disease.
Source: International Congress 2019 – Impact of sleep-disordered breathing in other diseases
Year: 2019

Visceral adipose tissue as a target for therapeutic intervention: an update
Source: Research Seminar 2009 - Intermittent hypoxia and adipose tissue - Insight into the pathophysiology of the Obstructive Sleep Apnoea Syndrome (OSAS) and treatment options
Year: 2009