Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation

N. Takasaka, J. Araya, Y. Kurita, K. Kobayashi, S. Ito, H. Wakui, Y. Yoshii, S. Minagawa, J. Kojima, H. Hara, T. Numata, K. Shimizu, M. Kawaishi, Y. Kaneko, K. Nakayama, K. Kuwano (Tokyo, Japan)

Source: International Congress 2014 – Cell biology 2014
Session: Cell biology 2014
Session type: Thematic Poster Session
Number: 3854
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Takasaka, J. Araya, Y. Kurita, K. Kobayashi, S. Ito, H. Wakui, Y. Yoshii, S. Minagawa, J. Kojima, H. Hara, T. Numata, K. Shimizu, M. Kawaishi, Y. Kaneko, K. Nakayama, K. Kuwano (Tokyo, Japan). Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation. Eur Respir J 2014; 44: Suppl. 58, 3854

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
KCa3.1 mediates alphaSMA expression in human lung myofibroblast via the Smad2/3 and TGFbeta1 signalling pathway
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Pirfenidone attenuates myofibroblast differentiation during insufficient mitophagy
Source: International Congress 2016 – IPF pathogenesis
Year: 2016


Loss of CARM1 prolongs bleomycin-induced pulmonary fibrosis
Source: International Congress 2014 – Animal models: asthma, COPD and beyond
Year: 2014

Dasatinib suppresses TGFbeta-induced epithelial mesenchymal transition and inhibits pulmonary fibrosis
Source: International Congress 2014 – ILDs 1
Year: 2014

Sulforaphane attenuates lung fibrosis in bleomycin-induced pulmonary fibrosis via inhibition of TGF-beta/Smad signaling
Source: International Congress 2014 – ILDs 4
Year: 2014

MiR-31 regulates IRF-1 function in cystic fibrosis epithelial cells
Source: International Congress 2014 – Novel epigenetic regulators for targeting via nanomedicine
Year: 2014

Proteasome function in lung fibrosis
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

Lipoxin (LXA4) as a novel therapy for idiopathic pulmonary fibrosis
Source: International Congress 2014 – New mechanisms in the pathogenesis of asthma and other lung diseases
Year: 2014

Effect of pirfenidone on TGF-beta-induced pro-fibrotic effects in primary human lung cells derived from patients with idiopathic pulmonary fibrosis
Source: International Congress 2014 – ILDs 2
Year: 2014

Bromodomain inhibitor JQ1 attenuates TGF-beta-suppressed SOD2 expression and reduces proliferation in human primary pulmonary fibroblasts
Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Year: 2013

Role of Wnt-1, Wnt-3 and MMP-7 in fibrotic response in extrinsic allergic alveolitis and idiopathic pulmonary fibrosis
Source: International Congress 2015 – Interstitial lung diseases II
Year: 2015

Metabolic shift during TGF- β-induced collagen synthesis
Source: International Congress 2016 – IPF pathogenesis
Year: 2016

Tranilast inhibits pulmonary fibrosis by suppressing TGFbeta-mediated extracellular matrix protein production
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013

Uncoupling the pro-fibrotic effects of TGF-beta1 versus tissue hardening in lung fibroblasts
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

Inhibitor effect of Janus kinase II in bleomycin-induced pulmonary fibrosis model
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014


Severe lung inflammation is a feature of IPF
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

A potential role for endothelial adhesion molecules and cytokines in chemotherapy-induced lung fibrosis
Source: International Congress 2014 – Cell biology 2014
Year: 2014


Inhibition of profibrotic signaling in fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) by histone deacetylase-inhibitors (HDACi) or the IPF drug pirfenidone
Source: International Congress 2014 – ILDs 1
Year: 2014

Aerobic training inhibits bleomycin-induced pulmonary fibrosis in BALB/c mice
Source: International Congress 2014 – Animal models: asthma, COPD and beyond
Year: 2014