Corticosteroid insensitivity in airway smooth muscle cells from severe asthma is dependent on stimulus and cytokine product

C. Rossios, D. Gibeon, K. F. Chung, I. M. Adcock, U-BIOPRED study group (London, United Kingdom)

Source: International Congress 2014 – Cell biology 2014
Session: Cell biology 2014
Session type: Thematic Poster Session
Number: 3846
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Rossios, D. Gibeon, K. F. Chung, I. M. Adcock, U-BIOPRED study group (London, United Kingdom). Corticosteroid insensitivity in airway smooth muscle cells from severe asthma is dependent on stimulus and cytokine product. Eur Respir J 2014; 44: Suppl. 58, 3846

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration
Source: International Congress 2014 – Cell biology 2014
Year: 2014


Hypoxia exerts dualistic effects on inflammatory and proliferative responses of healthy and asthmatic primary human bronchial smooth muscle cells
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Allergic asthma induce opposite changes in the expression of caveolin-1 and cavin-2 in airway and vascular pulmonary smooth muscle
Source: International Congress 2014 – Animal models: asthma, COPD and beyond
Year: 2014

The effect of JQ1/SGCBD01 upon c-Myc in human airway smooth muscle in asthma
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Secretion of hyaluronic acid is mediated by muscarinic receptors in airway smooth muscle cells of patients with COPD
Source: International Congress 2014 – Translational studies in COPD
Year: 2014

Mitochondrial membrane potential in the airway and skeletal muscle compartments of smokers with and without COPD
Source: International Congress 2014 – Translational studies in COPD
Year: 2014

Airway smooth muscle contractility is increased following coculture with fibrocytes
Source: International Congress 2016 – Mechanisms of disease
Year: 2016

Link between airway inflammation and remodeling: TNFα induces airway smooth muscle cell proliferation via an ET1/GMCSF/IL6 network
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Distribution of increased airway smooth muscle thickness and airway inflammation in asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

IL-13 induces glucocorticoid-insensitive hyperreactivity of human small airways
Source: International Congress 2015 – Modulating the immune system in COPD and asthma
Year: 2015

MNK-1 inhibition reduces proliferation and CXCL10 in airway smooth muscle cells
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

The role of glycolysis in TGF-beta-mediated airway smooth muscle cell proliferation
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Extracellular matrix within the airway smooth muscle layer correlates with age but not in cases of asthma
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016

Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Exaggerated airway narrowing is related to increased airway smooth muscle mass in bronchial segments from subjects with a history of asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Integrins regulate eosinophil adhesion to the airway smooth muscle cells in asthma patients
Source: International Congress 2015 – Asthma mechanisms and management
Year: 2015

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Mitochondrial reactive oxygen species (ROS) mediate proliferation and cytokine release in airway smooth muscle cells of patients with COPD
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Targeting ASK1 in preventing airway smooth muscle growth: Implications for airway remodeling in COPD
Source: International Congress 2016 – New findings in mucosal immunology
Year: 2016


Long-term effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in severe asthma
Source: International Congress 2016 – Asthma: from basic mechanisms to novel therapeutic perspectives
Year: 2016