LSC 2014 abstract - Deciphering of the mechanism of the anti-asthmatic action of the CXCL12 neutraligand, chalcone 4

F. Daubeuf, D. Bonnet, V. Beckaert, A. Ouadi, P. Marchand, D. Brasse, P. Gizzi, M. Hibert, J. L. Galzi, N. Frossard (Illkirch, Strasbourg, France)

Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Session: New drugs for asthma, COPD and pulmonary fibrosis
Session type: Oral Presentation
Number: 3415
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
F. Daubeuf, D. Bonnet, V. Beckaert, A. Ouadi, P. Marchand, D. Brasse, P. Gizzi, M. Hibert, J. L. Galzi, N. Frossard (Illkirch, Strasbourg, France). LSC 2014 abstract - Deciphering of the mechanism of the anti-asthmatic action of the CXCL12 neutraligand, chalcone 4. Eur Respir J 2014; 44: Suppl. 58, 3415

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Therapeutic potential of CPL-407-105 – Novel potent JAK/STAT pathway inhibitor for the treatment of asthma
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

In vitro characterization of a novel inhaled PI3Kd inhibitor LAS194223
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

The anti-inflammatory effects of sulforaphane are not mediated by the Nrf2 pathway
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Therapeutic blockade of IL-4 and 13 signaling with dupilumab (SAR231893/REGN668) inhibits key biomarkers in asthma
Source: Annual Congress 2013 –Treatment of asthma
Year: 2013

In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Characterization QAW039 and QAV680, two novel, potent and selective CRTh2 antagonists
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014


Redefining the asthma treatment paradigm using a locally administered dual PI3Kgd inhibitor
Source: International Congress 2016 – New therapies and therapeutic targets
Year: 2016



Anti-inflammatory effects of the novel phosphodiesterase type 4 inhibitor CHF6001 on COPD alveolar macrophages and lung tissue
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014


Inhibition of JAK/STAT pathway in airway epithelium as a potential targeted therapy of asthma
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014


QAW039, a slowly dissociating CRTh2 antagonist with potential for improved clinical efficacy
Source: International Congress 2014 – Allergy and asthma: novel findings based on human cell biology
Year: 2014


The inverse agonist propranolol does not confer steroid-sparing activity in persistent asthma
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014


Expression of CysLT2 receptors in asthmatic lung, and the roles in bronchoconstriction
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

An antedrug of the CXCL12 neutraligand blocks experimental allergic asthma without systemic effect in the mouse
Source: Annual Congress 2013 –Novel drugs for the treatment of asthma and COPD
Year: 2013

Bronchoprotective activity and safety assessment of two novel dual-acting MABA compounds (LAS190792 and LAS191351) in dogs
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014

Discovery of PRS-060, an inhalable CD123/IL4Ra/TH2 blocking anti-asthmatic anticalin protein re-engineered from endogenous lipocalin-1
Source: International Congress 2015 – Novel targets and strategies for the treatment of cough, asthma, rhinosinusitis and COPD
Year: 2015

LSC 2014 abstract - Targeting of microRNAs can restore innate anti-viral response in asthma
Source: International Congress 2014 – Novel epigenetic regulators for targeting via nanomedicine
Year: 2014


Enhanced anti-inflammatory gene expression in humans following inhaled budesonide
Source: Annual Congress 2013 –Novel pharmacological findings in the management of respiratory disorders
Year: 2013

ALX-0962, an anti-IgE Nanobody® with a dual mode of action
Source: Annual Congress 2013 –Novel drugs for the treatment of asthma and COPD
Year: 2013