Long-lasting interaction study between RPL554 and glycopyrronium bromide on human isolated bronchi

L. Calzetta, M. Cazzola, C. Page, P. Rogliani, F. Facciolo, M. G. Matera (Rome, Naples, Italy; London, United Kingdom)

Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Session: Novel approaches and evidence for drug development in respiratory diseases
Session type: Poster Discussion
Number: 3334
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
L. Calzetta, M. Cazzola, C. Page, P. Rogliani, F. Facciolo, M. G. Matera (Rome, Naples, Italy; London, United Kingdom). Long-lasting interaction study between RPL554 and glycopyrronium bromide on human isolated bronchi. Eur Respir J 2014; 44: Suppl. 58, 3334

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Interaction between RPL554 and glycopyrronium bromide in small human airways
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Interaction between aclidinium bromide and formoterol fumarate in small human airways
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Interaction between aclidinium bromide and formoterol fumarate; effects on human bronchial smooth muscle
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Effectiveness of glycopyrronium bromide in the treatment of small airways dysfunction
Source: International Congress 2016 – Novel avenues in the treatment of COPD II
Year: 2016

Pharmacological interaction between glycopyrronium bromide and indacaterol fumarate on the human airways tone
Source: International Congress 2016 – Preclinical pharmacology: drug targets and mechanisms of action
Year: 2016

Pharmacological characterization of the mechanism of action leading to synergism between glycopyrronium bromide and indacaterol fumarate
Source: International Congress 2016 – Airway pharmacology: drug targets and mode of action
Year: 2016

Tiotropium respimat: Comparison of bronchodilator efficacy of 5 and 2.5 µg doses
Source: International Congress 2014 – Asthma and COPD devices and treatments
Year: 2014


The dual PDE3/PDE4 phosphodiesterase inhibitor RPL554 produces more complete bronchodilator responses than the beta2-agonist salbutamol and the anti-muscarinic agent ipratropium bromide, alone and in combination, in guinea-pig isolated trachea
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015


Translational study searching for synergy between glycopyrronium and indacaterol
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Bronchodilator activity of the combination of salbutamol hemisuccinate and methatropium iodide compared with monotherapy in preclinical studies
Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis
Year: 2015

The combination therapy with inhaled tiotropium bromide and indacaterol in COPD improves the peripheral airway function in static and dynamic status
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

The effect of twice-daily aclidinium bromide on cough and sputum in patients with COPD: Results from phase III studies
Source: International Congress 2014 – Asthma and COPD devices and treatments
Year: 2014

Mixed treatment analysis comparing tiotropium HandiHaler® and Respimat®
Source: International Congress 2014 – Asthma and COPD devices and treatments
Year: 2014


Once-daily QVA149 improves lung function and dyspnoea compared with tiotropium plus formoterol: The QUANTIFY study
Source: International Congress 2014 – Asthma and COPD management
Year: 2014


Combination study of tiotropium and olodaterol in human precision-cut lung slices
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013


Effects of inhaled salmeterol/fluticasone on lung function in patients with bronchiectasis
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014


Long-acting anticholinergics in the treatment of severe asthma with irreversible airway obstruction
Source: International Congress 2014 – New clinical evidence for asthma and COPD treatments
Year: 2014

Efficacy and safety of abediterol, a long-acting beta2-adrenergic agonist (LABA); three phase II trials in asthma
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014

Once-daily tiotropium respimat add-on to ICS±LABA improves control across asthma severities
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014



Interaction between tiotropium  bromide and olodaterol in small human airways
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017