Transcription factor EB (TFEB) regulates cigarette smoke extract (CSE)-induced cellular senescence

Y. Kurita, J. Araya, H. Hara, K. Kobayashi, S. Ito, N. Takasaka, H. Wakui, Y. Yoshii, S. Minagawa, J. Kojima, T. Numata, K. Shimizu, M. Kawaishi, Y. Kaneko, K. Nakayama, K. Kuwano (Tokyo, Japan)

Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Session: Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Session type: Oral Presentation
Number: 3243
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Y. Kurita, J. Araya, H. Hara, K. Kobayashi, S. Ito, N. Takasaka, H. Wakui, Y. Yoshii, S. Minagawa, J. Kojima, T. Numata, K. Shimizu, M. Kawaishi, Y. Kaneko, K. Nakayama, K. Kuwano (Tokyo, Japan). Transcription factor EB (TFEB) regulates cigarette smoke extract (CSE)-induced cellular senescence. Eur Respir J 2014; 44: Suppl. 58, 3243

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PINK1-Parkin pathway-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Carbocysteine reverts the effects of cigarette smoke on the growth and on the senescence of bronchial epithelial cells
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014


Acute cigarette smoke induces accelerated emphysema development in bENaC-overexpressed mice
Source: International Congress 2014 – Animal models: asthma, COPD and beyond
Year: 2014


Involvement of PKCeta activation in cigarette smoke extract induced apoptosis in human lung fibroblasts (MRC-5 cell)
Source: International Congress 2014 – Lung cell biology in injury and repair
Year: 2014

Involvement of mitochondrial fragmentation in cigarette smoke induced-bronchial epithelial cell senescence
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Cigarette smoke impairs autophagic flux in bronchial epithelial cells
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Cigarette smoke inhibits lung fibroblast proliferation by translational mechanisms
Source: Eur Respir J 2012; 39: 705-711
Year: 2012



Cigarette smoke affects differentiation and function of primary human bronchial epithelial cells
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Parkin-mediated mitophagy is involved in cigarette smoke extract (CSE)-induced cellular senescence in human bronchial epithelial cells (HBEC)
Source: Annual Congress 2013 –Stress responses and T-cell behaviour in the lung
Year: 2013

Cigarette smoke modulates the PKAc-associated cross-coupling between NF-kB and glucocorticoid receptor in primary small airway epithelial cells
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013

The effects of INTS12 knockdown on processing of snRNAs
Source: International Congress 2014 – Novel epigenetic regulators for targeting via nanomedicine
Year: 2014



Impact of cigarette smoke on function and expression of immunoproteasomes
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Recurrent cigarette smoke exposure impairs SIRT1 shuttling in bronchial epithelial cells
Source: International Congress 2016 – Translational studies in lung disease
Year: 2016

The expression of the negative regulator of gene transcription SOCS3 as the crucial marker in the asthma pathogenesis
Source: International Congress 2014 – New mechanisms in the pathogenesis of asthma and other lung diseases
Year: 2014

Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by cytotoxic/ pro-inflammatory lymphocytes
Source: International Congress 2014 – Effect of cigarette smoke on cell behaviour: cell biology, signalling and senescence
Year: 2014

Carbocysteine restores the expression and the activation of TLR4 altered by cigarette smoke extracts in bronchial epithelial cells
Source: Annual Congress 2013 –Molecular biology: state-of-the-art 2013
Year: 2013

Cigarette smoke impairs Sirt1 activity and promotes pro-inflammatory responses in bronchial epithelial cells
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

The role of cyclooxygenas-2 in the protection against apoptosis in vascular endothelial cells induced by cigarette smoking
Source: International Congress 2014 – Basic and translational research in asthma and COPD
Year: 2014


Cigarette smoke extract induces the release of extracellular vesicles by airway epithelial cells via cellular carbonyl stress
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Non-canonical WNT-5A signaling attenuates endogenous lung repair in COPD
Source: International Congress 2016 – New signalling pathways in COPD
Year: 2016