Hypoxia and the hypoxia-regulated transcription factor HIF-1alpha suppress the host defense of the respiratory epithelium

M. Polke, P. Lepper, A. Kamyschnikow, F. Langer, D. Monz, C. Herr, R. Bals, C. Beisswenger (Homburg (Saar), Germany)

Source: International Congress 2014 – Different interesting issues in respiratory infections: 1
Session: Different interesting issues in respiratory infections: 1
Session type: Thematic Poster Session
Number: 2547
Disease area: Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Polke, P. Lepper, A. Kamyschnikow, F. Langer, D. Monz, C. Herr, R. Bals, C. Beisswenger (Homburg (Saar), Germany). Hypoxia and the hypoxia-regulated transcription factor HIF-1alpha suppress the host defense of the respiratory epithelium. Eur Respir J 2014; 44: Suppl. 58, 2547

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A major inflammatory cytokine IL-1β inhibits the ventilatory response to hypoxia
Source: International Congress 2016 – Hypoxia, oxidative stress, and biomarkers in obstructive sleep apnoea
Year: 2016


Validation of an in vitro tracheal model for the study of innate host defence mechanism in respiratory tract infections
Source: International Congress 2014 – Cells, biofilms and biomarkers in respiratory infections
Year: 2014


Pneumolysin causes cyotoxicity and ciliary stasis in human respiratory epithelial cells
Source: International Congress 2014 – Pathogenesis and mechanisms of respiratory infections
Year: 2014


Airway epithelial cell IP-10 production is regulated by miR-31 via the transcription factor IRF-1
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Oral Presentation: Endogenous transforming growth factor influences rhinovirus replication in primary bronchial epithelial cells by suppressing the innate immune response
Source: Lung Science Conference 2011 - Immune system dysregulation in chronic lung disease
Year: 2011

Targeted silencing of master transcription factor SPDEF to reduce mucus production in airway diseases by epigenetic editing
Source: International Congress 2015 – Advances in the future treatment of COPD
Year: 2015



FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells
Source: Annual Congress 2012 - New insights into airway epithelial cell physiology
Year: 2012

Epithelial NF-κB regulates bacterial translocation in the respiratory tract
Source: Annual Congress 2013 –Murine models of lung immunology
Year: 2013

Endothelin-1 contributes to the downregulation of BMP/BMPR2 signaling induced by hypoxia
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells
Source: Eur Respir J 2012; 39: 712-720
Year: 2012



Microvesicles derived from alveolar macrophages mediate epithelial activation via a TNF dependant mechanism
Source: International Congress 2015 – Novel insights into the pathobiology of acute lung injury
Year: 2015

HIF Gene expression and Hypoxia signalling
Source: Research Seminar 2005 - Adaptations to Hypoxia
Year: 2005

LSC 2012 abstract – FOXO transcription factors regulate innate immune mechanisms in respiratory epithelial cells during bacterial infection
Source: Annual Congress 2012 - Immunologic mechanisms in COPD and asthma
Year: 2012

Regulation of VEGF receptors and co-factors by hypoxia and hyperoxia
Source: Annual Congress 2012 - Lung injury and repair: reactive oxygen species and beyond
Year: 2012

Ventilation-induced neutrophil infiltration depends on nuclear factor-kB and NF-kB repressing factor
Source: Annual Congress 2013 –Novel mechanisms in lung injury
Year: 2013

Hypoxia inducible factor-1? in human emphysema lung tissue
Source: Eur Respir J 2011; 37: 775-783
Year: 2011



Mesenchymal stem cell-conditioned medium induces neutrophils apoptosis via inhibition of NF-kB pathway and increases endogenous pulmonary stem cells in endotoxin-induced acute lung injury
Source: International Congress 2015 – The multiple facets of stem and progenitor cells in lung health and disease
Year: 2015

Role of the immunoregulatory microRNA miR-146a in the innate immune response to rhinovirus infection
Source: Annual Congress 2013 –Viral infections: what is new?
Year: 2013


Genome-wide chromatin profiling of legionella pneumophila-infected human macrophages reveals activation of the pro-bacterial host factor TNFAIP2
Source: International Congress 2016 – Airway response to infection
Year: 2016