NSP4 is an elastase-related protease with arginine specificity that is released by activated human neutrophils as an active endoprotease

N. Perera, W. Back, K. H. Wiesmüller, M. Torp-Larsen, N. Borregaard, D. Jenne (München, Bremerhaven, Tübingen, Planegg-Martinsried, Germany; Copenhagen, Denmark)

Source: International Congress 2014 – Mechanisms of COPD: proteases and a whole lot more
Session: Mechanisms of COPD: proteases and a whole lot more
Session type: Poster Discussion
Number: 1843
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
N. Perera, W. Back, K. H. Wiesmüller, M. Torp-Larsen, N. Borregaard, D. Jenne (München, Bremerhaven, Tübingen, Planegg-Martinsried, Germany; Copenhagen, Denmark). NSP4 is an elastase-related protease with arginine specificity that is released by activated human neutrophils as an active endoprotease. Eur Respir J 2014; 44: Suppl. 58, 1843

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pathogenic potential of an autoprocessed form of neutrophil elastase
Source: International Congress 2014 – Mechanisms of COPD: proteases and a whole lot more
Year: 2014

Plant Kunitz proteinase inhibitor attenuates inflammation, oxidative stress and remodeling induced by elastase in mice
Source: International Congress 2014 – Mechanisms of COPD: proteases and a whole lot more
Year: 2014

Development of secretory leukocyte protease inhibitor (SLPI) variants resistant to degradation by neutrophil elastase
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014

Viral mimetic Poly(I:C) exacerbates cigarette smoke-induced pulmonary inflammation by facilitating the release of neutrophil-derived elastase
Source: International Congress 2014 – Mechanisms of COPD and inhalation injury
Year: 2014


Dipeptidyl peptidase I (DPPI) cleaves surfactant protein D (SP-D): A mechanism for immune compromise in the lung
Source: International Congress 2016 – Molecular immunology of the lung
Year: 2016



Matriptase triggers pleiotropic functional responses in normal human lung fibroblasts (NHLF): Potential relevance in pathophysiology
Source: International Congress 2014 – Lung cell biology in injury and repair
Year: 2014

Smoking alters alpha1-antitrypsin in alveolar macrophages possibly promoting misfolding
Source: International Congress 2014 – New studies into pulmonary proteases and antiproteases
Year: 2014

Acute phase protein alpha1-antitrypsin - A novel regulator of angiopoietin-like protein 4 transcription and secretion in human cells
Source: International Congress 2014 – Mechanisms of COPD: proteases and a whole lot more
Year: 2014


Reduction of high mobility group nucleosome binding domain-5 protein promotes the development of emphysema
Source: International Congress 2014 – Mechanisms of COPD: proteases and a whole lot more
Year: 2014

Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-induced acute pneumonitis in mice
Source: International Congress 2014 – Experimental models in acute lung injury
Year: 2014


Metalloproteases gene expression and remodeling of lung parenchyma fibers during the progression of elastase induced emphysema
Source: International Congress 2014 – Mechanisms of COPD and inhalation injury
Year: 2014


Lung injury and apoptosis in COPD: Effect of a recombinant anti-protease derived from trappin-2
Source: Annual Congress 2011 - Novel mechanisms in lung injury
Year: 2011

Effects of extracellular vesicles from mesenchymal stromal cells in experimental silicosis
Source: International Congress 2014 – Pulmonary fibrosis: receptors, signalling pathways and mesenchymal cells
Year: 2014

LSC 2014 abstract - The role of the formyl peptide receptor in the development of pulmonary fibrosis
Source: International Congress 2014 – Pulmonary fibrosis: receptors, signalling pathways and mesenchymal cells
Year: 2014

Microvesicles derived from alveolar macrophages mediate epithelial activation via a TNF dependant mechanism
Source: International Congress 2015 – Novel insights into the pathobiology of acute lung injury
Year: 2015

Plant proteinase from bauhinia bauhinioides kallikrein inhibitor (BbKI) attenuates inflammation and remodelling induced by elastase in mice
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

Rapid activation of pulmonary endothelial cells during high stretch ventilation in vivo
Source: International Congress 2014 – Acute lung injury: hitting the barriers
Year: 2014



Impact of Wnt ligand secretion on cellular phenotypes in pulmonary fibrosis
Source: International Congress 2014 – New and old players in fibrotic lung disease
Year: 2014

Dexamethasone inhibits secretory and cytosolic phospholipases A2 in alveolar macrophages in acute lung injury
Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection
Year: 2013

Polarization of alveolar macrophages is regulated by the immunoproteasome
Source: International Congress 2014 – Lung cell biology in injury and repair
Year: 2014