Effect of the CYP3A4 inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of AZD5069, an oral CXCR2 antagonist

M. Cullberg, H. Wray, B. Larsson (Mölndal, Sweden)

Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Session: Novel evidence relating to respiratory treatment development
Session type: Thematic Poster Session
Number: 961
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
M. Cullberg, H. Wray, B. Larsson (Mölndal, Sweden). Effect of the CYP3A4 inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of AZD5069, an oral CXCR2 antagonist. Eur Respir J 2014; 44: Suppl. 58, 961

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

AZD5069: Pharmacological profile of a CXCR2 antagonist in development for the treatment of respiratory disorders
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

The novel elastase inhibitor BAY 85-8501: Bioavailability and Food effect study to evaluate pharmacokinetics of tablet formulations
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Effect of the combination of doxofylline and montelukast on LPS-induced leukocyte migration to the lung
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

In vitro characterization of a novel inhaled PI3Kd inhibitor LAS194223
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

LATE-BREAKING ABSTRACT: Safety, pharmacokinetics and pharmacodynamics of BI 1060469, a novel oral CRTH2 antagonist
Source: International Congress 2016 – Asthma management
Year: 2016


Efficacy and safety of AZD5069, a CXCR2 antagonist, in adult bronchiectasis
Source: Annual Congress 2013 –New drugs in respiratory medicine
Year: 2013

Effect of CYP3A4 inhibitors verapamil and itraconazole on the pharmacokinetics of AZD7986, an oral DPP1 inhibitor
Source: International Congress 2017 – Asthma management
Year: 2017


Pharmacokinetics of selective PI3Kδ inhibitors after intratracheal instillation in mice
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Repeated-dose pharmacokinetics of once-daily TD-4208, a long-acting muscarinic receptor antagonist (LAMA), in subjects with COPD
Source: International Congress 2014 – Bronchodilators for asthma and COPD
Year: 2014


In vivo efficacy of CHF6001, an inhaled PDE4 inhibitor with a wide therapeutic window
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014


Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Bronchoprotective activity and safety assessment of two novel dual-acting MABA compounds (LAS190792 and LAS191351) in dogs
Source: International Congress 2014 – Novel targets and drugs for asthma and COPD
Year: 2014

Anti-inflammatory effects of roflumilast N-oxide and dexamethasone in human bronchial epithelial cells stimulated with toll-like receptor agonists
Source: Annual Congress 2013 –The pulmonary epithelium: recent developments
Year: 2013


Safety, tolerability and pharmacokinetics of a new inhaled once-daily phosphodiesterase (PDE) 4 inhibitor in healthy volunteers
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Abediterol has higher bronchodilatory potency and reduced cardiac effects versus other long-acting beta2-agonists in dogs
Source: International Congress 2014 – Rationale behind respiratory drug development
Year: 2014

The novel elastase inhibitor BAY 85-8501: First-in-man study to evaluate safety, tolerability and pharmacokinetics in healthy male subjects
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014


Effects of the new ultra-long-acting β2-AR agonist indacaterol in chronic treatment alone or in combination with the β1-AR blocker metoprolol on cardiac remodelling
Source: International Congress 2015 – Safety of and interactions between current treatments for asthma and COPD
Year: 2015

The effect of the inhaled PDE4 inhibitor CHF6001 on allergen-induced inflammation in asthmatics
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

The in vitro profile of ADC3680, a potent and selective CRTh2 antagonist for the treatment of inadequately controlled asthma
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013