AZD5069: Pharmacological profile of a CXCR2 antagonist in development for the treatment of respiratory disorders

C. Kärrman Mårdh, D. Nicholls, I. Dainty, C. Phillips, F. McIntosh (Mölndal, Sweden; Alderley Park, Charnwood, United Kingdom)

Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Session: Novel evidence relating to respiratory treatment development
Session type: Thematic Poster Session
Number: 960
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Kärrman Mårdh, D. Nicholls, I. Dainty, C. Phillips, F. McIntosh (Mölndal, Sweden; Alderley Park, Charnwood, United Kingdom). AZD5069: Pharmacological profile of a CXCR2 antagonist in development for the treatment of respiratory disorders. Eur Respir J 2014; 44: Suppl. 58, 960

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
In vitro characterization of a novel inhaled PI3Kd inhibitor LAS194223
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

In vitro profile of the new inhaled pan-JAK inhibitor LAS194046
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

A novel inhaled PI3Kδ inhibitor, LAS194223 reduces allergen-induced airway inflammation in rat
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014

Side effects of the leukotriene receptor antagonists in asthmatic children
Source: International Congress 2014 – Asthma and COPD devices and treatments
Year: 2014


Blockade of TSLP pathway alters asthma biomarkers
Source: International Congress 2014 – Clinical trials of drugs for respiratory diseases
Year: 2014

The inverse agonist propranolol does not confer steroid-sparing activity in persistent asthma
Source: International Congress 2014 – Clinical trials of drugs and biomarkers for respiratory diseases
Year: 2014


Anti-inflammatory effects of targeted lung denervation in patients with COPD
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Clinical effectiveness of anti-IgE therapy in allergic severe asthma
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

Effect of the CYP3A4 inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of AZD5069, an oral CXCR2 antagonist
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014

The effect of the inhaled PDE4 inhibitor CHF6001 on allergen-induced inflammation in asthmatics
Source: International Congress 2014 – Asthma and COPD management
Year: 2014

Expression of CysLT2 receptors in asthmatic lung, and the roles in bronchoconstriction
Source: International Congress 2014 – Novel approaches and evidence for drug development in respiratory diseases
Year: 2014

Inhibition of JAK/STAT pathway in airway epithelium as a potential targeted therapy of asthma
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014


Preclinical characterization of CPL-302-201, a novel, highly potent and selective PI3Kδ inhibitor for the treatment of inflammatory disorders
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Comparison of three modalities of corticosteroids administration in chronic rhinosinusitis
Source: International Congress 2014 – Novel evidence relating to respiratory treatment development
Year: 2014


Therapeutic potential of CPL-407-105 – Novel potent JAK/STAT pathway inhibitor for the treatment of asthma
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

New inhaled JAK inhibitor LAS194046 inhibits allergen-induced airway inflammation in Brown Norway rats
Source: International Congress 2014 – New drugs for asthma, COPD and pulmonary fibrosis
Year: 2014

Additive anti-inflammatory effect of glucocorticoids and PDE4 inhibitors on COPD CD8 cells
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Effect of the combination of doxofylline and montelukast on LPS-induced leukocyte migration to the lung
Source: International Congress 2014 – Animal models in respiratory drug development
Year: 2014

H4 receptor antagonits as a potential medication for upper airway cough syndrom
Source: International Congress 2014 – New treatments for cough, asthma, COPD and ILDs
Year: 2014

Long-acting anticholinergics in the treatment of severe asthma with irreversible airway obstruction
Source: International Congress 2014 – New clinical evidence for asthma and COPD treatments
Year: 2014