Bromodomain inhibitor JQ1 attenuates TGF-beta-suppressed SOD2 expression and reduces proliferation in human primary pulmonary fibroblasts

G. Lindahl, P. Leoni, C. Stock, C. Michaeloudes, H. Lota, A. Nicholson, T. Maher, A. Wells, I. Adcock, E. Renzoni (London, United Kingdom)

Source: Annual Congress 2013 –The multiple faces of stress in lung injury
Session: The multiple faces of stress in lung injury
Session type: Thematic Poster Session
Number: 3911
Disease area: Interstitial lung diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
G. Lindahl, P. Leoni, C. Stock, C. Michaeloudes, H. Lota, A. Nicholson, T. Maher, A. Wells, I. Adcock, E. Renzoni (London, United Kingdom). Bromodomain inhibitor JQ1 attenuates TGF-beta-suppressed SOD2 expression and reduces proliferation in human primary pulmonary fibroblasts. Eur Respir J 2013; 42: Suppl. 57, 3911

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Inhibition of collagen cross-links by novel LOXL2 selective inhibitors in an in-vitro model of fibroblastic foci of IPF
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Targetingpyruvate kinase M2 isoform inhibits proliferation of human lung fibroblasts
Source: International Congress 2016 – ILD: from the bench to the bedside
Year: 2016

Reactivation of developmental pathways in idiopathic pulmonary fibrosis: FGF9 and FGF18 modulate the phenotype of control and fibrotic human lung fibroblasts in vitro
Source: International Congress 2015 – IPF: from bench to bedside
Year: 2015

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: Role of transmembrane SCF and PAR-2/PKCalpha/Raf-1/p44/42 signaling pathway
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

Uncoupling the pro-fibrotic effects of TGF-beta1 versus tissue hardening in lung fibroblasts
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis and rarities
Year: 2013

Role of Bcl-xL in hepatocyte growth factor elicited epithelial protection in idiopathic lung fibrosis
Source: Annual Congress 2013 –Idiopathic pulmonary fibrosis: pathogenesis
Year: 2013

Tranilast inhibits pulmonary fibrosis by suppressing TGFbeta-mediated extracellular matrix protein production
Source: Annual Congress 2013 –Diffuse pulmonary fibrosis
Year: 2013

ATF3 regulates PINK1 transcription in lung epithelial cells of the aging lung
Source: International Congress 2016 – Repair pathways: from lung development to ageing of the lung
Year: 2016

Does apoptosis evasion only affect fibroblasts from idiopathic pulmonary fibrosis?
Source: Annual Congress 2013 –Cell signalling and inflammation: what's new in 2013?
Year: 2013

Metformin inhibits TGF-b-induced myofibroblast differentiation through AMPK activation
Source: International Congress 2014 – Cell biology 2014
Year: 2014

Distinct gene expression profiles of cultured stromal cells from the patients with idiopathic pulmonary fibrosis and lung adenocarcinoma
Source: International Congress 2015 – Translational studies in airway cell biology
Year: 2015

Effect of pirfenidone on TGF-beta-induced pro-fibrotic effects in primary human lung cells derived from patients with idiopathic pulmonary fibrosis
Source: International Congress 2014 – ILDs 2
Year: 2014

SRC family kinase inhibition reduces NOX4 expression in bronchial epithelial cells from Idiopathic Pulmonary Fibrosis patients
Source: International Congress 2019 – Damage and remodelling in pulmonary fibrosis
Year: 2019



A role of Foxc2 gene in mice with bleomycin-induced pulmonary fibrosis
Source: International Congress 2015 – Pulmonary fibrosis: mechanisms of disease
Year: 2015


Effect of nintedanib, pirfenidone, N-acetylcysteine and their combinations on cultured myofibroblast-type cells derived from patients with asbestosis and idiopathic pulmonary fibrosis
Source: International Congress 2015 – Airway remodelling: recent developments
Year: 2015

Dasatinib suppresses TGFbeta-induced epithelial mesenchymal transition and inhibits pulmonary fibrosis
Source: International Congress 2014 – ILDs 1
Year: 2014

The enhancement of Stanniocalcin-1 (STC1) secretion increases the ability of mesenchymal stem cells (MSCs) to reduce bleomycin-induced lung fibrosis in a mouse model through inhibition of endoplasmic reticulum stress (ER-stress)/TGFbeta1 pathway
Source: International Congress 2014 – ILDs 1
Year: 2014


Pirfenidone attenuates myofibroblast differentiation during insufficient mitophagy
Source: International Congress 2016 – IPF pathogenesis
Year: 2016


Thyroid hormone inhibits pulmonary fibrosis through enhancement of mitochondrial function in alveolar epithelial cells
Source: International Congress 2016 – IPF: from pathogenesis to treatment I
Year: 2016


Toll like receptor 4 activation upregulates miR-181b attenuating pulmonary fibrosis via targeting TGFBR1
Source: International Congress 2015 – Latest news on miRNAs in pulmonary research
Year: 2015