Evidence of in vivo esterification of budesonide in humans

K. I. Maassen van den Brink, J. Staal-van den Brekel, M. Boorsma, S. Edsbacker, E. F. Wouters, L. Thorsson (Maastricht, Zoetermeer, Netherlands; Lund, Sweden)

Source: Annual Congress 2005 - Current and emerging anti-inflammatory therapies
Session: Current and emerging anti-inflammatory therapies
Session type: Thematic Poster Session
Number: 2389
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. I. Maassen van den Brink, J. Staal-van den Brekel, M. Boorsma, S. Edsbacker, E. F. Wouters, L. Thorsson (Maastricht, Zoetermeer, Netherlands; Lund, Sweden). Evidence of in vivo esterification of budesonide in humans. Eur Respir J 2005; 26: Suppl. 49, 2389

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Tissue retention and esterification is greater for budesonide than for ciclesonide in trachea ex vivo
Source: Eur Respir J 2004; 24: Suppl. 48, 345s
Year: 2004

Esterification prolongs retention of budesonide but not ciclesonide - active principle in rat trachea
Source: Eur Respir J 2005; 26: Suppl. 49, 369s
Year: 2005

Greater esterification and retention of budesonide in the airways and lung as compared to ciclesonide after repeated intratracheal administration in vivo
Source: Eur Respir J 2004; 24: Suppl. 48, 345s
Year: 2004

Highly lipophilic fatty acid esters of the active metabolite of ciclesonide formed in vitro in rat lung tissue
Source: Eur Respir J 2004; 24: Suppl. 48, 345s
Year: 2004

Reversible intracellular esterification increases budesonide airway selectivity
Source: Eur Respir J 2001; 18: Suppl. 33, 158s
Year: 2001

Pharmacokinetic factors affecting airway selectivity of inhaled steroids - role of intracellular esterification
Source: Eur Respir J 2001; 18: Suppl. 33, 147s
Year: 2001

Deposition and metabolism of inhaled ciclesonide in the human lung
Source: Eur Respir J 2010; 36: 1113-1119
Year: 2010



Budesonide is retained in the airways longer than mometasone furoate due to the reversible formation of lipophilic budesonide fatty acid esters - significance for asthma therapy
Source: Eur Respir J 2002; 20: Suppl. 38, 53s
Year: 2002

The combination of budesonide and formoterol exerts more rapid and enhanced anti-inflammatory effects than either drug alone in rat lungs in vivo
Source: Eur Respir J 2004; 24: Suppl. 48, 344s
Year: 2004

Synergistic interaction between beclomethasone diproprionate and formoterol fumarate in an ex vivo model of bronchial asthma
Source: International Congress 2018 – Basic pharmacology
Year: 2018

Preclinical in vivo assessment of ciclesonide, a novel corticosteroid for the treatment of asthma
Source: Eur Respir J 2001; 18: Suppl. 33, 95s
Year: 2001

Budesonide esterification in human bronchial epithelial cells is not impaired by formoterol
Source: Eur Respir J 2002; 20: Suppl. 38, 619s
Year: 2002

In vitro metabolism of ciclesonide, beclomethasone dipropionate, budesonide and fluticasone propionate in human precision-cut lung slices
Source: Eur Respir J 2005; 26: Suppl. 49, 255s
Year: 2005

Effect of a novel inhaled glucocorticoid, ciclesonide, on an allergen-induced asthmatic response in rats and its prolonged anti-inflammatory activity in vitro
Source: Eur Respir J 2002; 20: Suppl. 38, 91s
Year: 2002

Pharmacokinetic factors affecting airway selectivity of inhaled steroids – role of prodrug conversion and absorption
Source: Eur Respir J 2004; 24: Suppl. 48, 347s
Year: 2004

Tissue accumulation kinetics of ciclesonide-active metabolite and budesonide in mice
Source: Annual Congress 2008 - Novel experimental approaches to understanding asthma and COPD II
Year: 2008

In vitro anti-inflammatory activity of the new glucocorticoid ciclesonide in human cells
Source: Eur Respir J 2001; 18: Suppl. 33, 95s
Year: 2001

Different tissue accumulation kinetics of ciclesonide-active metabolite and budesonide in mice
Source: Eur Respir J 2006; 28: Suppl. 50, 433s
Year: 2006

Esterases involved in the hydrolysis of ciclesonide in human tissues
Source: Eur Respir J 2003; 22: Suppl. 45, 267s
Year: 2003

Prolonged activity where it matters - the reversible esterfication of budesonide improves its topical anti-inflammatory efficacy and selectivity in the airways
Source: Eur Respir J 2001; 18: Suppl. 33, 21s
Year: 2001