Endothelin receptor antagonists (ERAs) neutralize LPS-induced cytokine release from pulmonary vascular smooth muscle cells (PVSMCs) by down-regulation of CD14

D. Jungck, M. Feldmann, C. Wahl, J. Behr, E. Stoelben, J. Knobloch, A. Koch (Bochum, Cologne, Germany)

Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Session: Airway smooth muscle and cell biology
Session type: Thematic Poster Session
Number: 555
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Jungck, M. Feldmann, C. Wahl, J. Behr, E. Stoelben, J. Knobloch, A. Koch (Bochum, Cologne, Germany). Endothelin receptor antagonists (ERAs) neutralize LPS-induced cytokine release from pulmonary vascular smooth muscle cells (PVSMCs) by down-regulation of CD14. Eur Respir J 2013; 42: Suppl. 57, 555

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Endothelin receptor B (ETBR) dependent GM-CSF mRNA stabilization explains the higher efficacy of bosentan vs. ambrisentan in the reduction of GM-CSF release from human airway smooth muscle cells (HASMCs)
Source: Annual Congress 2011 - Experimental modulation of airway inflammation
Year: 2011

The dissociated steroid receptor ligand from plant origin called compound A (CpdA) inhibits the production of steroid-resistant chemokines induced by TNFα/IFNγ in airway smooth muscle (ASM) cells in both asthma and healthy subjects
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

Remicade suppresses cytokine-induced up-regulation of bradykinin receptor-mediated airway smooth muscle contractions
Source: Annual Congress 2005 - Inflammation and the airway smooth muscle: cellular and pharmacological interactions
Year: 2005


The inflammatory response of pulmonary vascular smooth muscle cells to bacterial endotoxin is sensitive to endothelin receptor antagonism
Source: Annual Congress 2012 - Phenotypes and mechanisms of treatment of asthma
Year: 2012

Anti-inflammatory effect of bosentan on endothelin-1- and TNF-α-induced GMCSF expression in human airways smooth muscle cells – role of MAPkinases ERK-1,-2
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


TNFα stimulates the expression different chemokines including CXCl10, CCL5 and CXCL8 in developing airway smooth muscle (ASM) cells: Modulation by fluticasone and TNFα receptors
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

Resveratrol impairs cytokine release from human airway smooth muscle cells (HASMCs) and alveolar macrophages (AM) in COPD
Source: Annual Congress 2009 - Models of chronic airways disease and therapy
Year: 2009

Protease activated receptor 2 (PAR2) antagonism reduces pro-inflammatory cytokine production in bronchial epithelial cells
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020


Impaired inhibitory action of corticosteroids on chemokine expression induced by TNFalpha in airway smooth muscle (ASM) cells from patients with severe asthma
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013

Endothelin receptor B protects GM-CSF mRNA from degradation in human airway smooth muscle cells
Source: International Congress 2015 – Immunomodulation: basic science and clinical aspects
Year: 2015

Compound A (CpdA) suppressed production of corticosteroid-resistant chemokines via GR-independent mechanisms in airway smooth muscle (ASM) cells
Source: Annual Congress 2013 –Preclinical models for the development of new drugs for respiratory diseases
Year: 2013

Serotonin (5-hydroxytryptamine) modulates cytokine and chemokine production in lipopolysaccharide-primed human monocytes via stimulation of different 5-HT receptor subtypes
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Elevated CCL2 responses in COPD and attenuation by selective chemokine receptor antagonists
Source: International Congress 2015 – Therapeutic approaches in inflammatory lung disease
Year: 2015

RANTES expression induced by Toll-like receptor 3 and 4 ligands on rat airway smooth muscle cells
Source: Annual Congress 2009 - Infections, immunity and inflammation
Year: 2009


Resveratrol is superior to dexamethasone in suppressing cytokine release from human airway smooth muscle cells exposed to lipoteichoic acid in COPD
Source: Annual Congress 2013 –Airway smooth muscle and cell biology
Year: 2013


Effects of bosentan, ambrisentan and TBC3711 on TNFα induced and endothelin-1 modulated gm-csf expression in human airway smooth muscle cells
Source: Annual Congress 2009 - Airway cell biology
Year: 2009


Expression of bradykinin B2 receptor (B2R) and vascular endothelial growth factor (VEGF) in asthma and COPD
Source: Eur Respir J 2007; 30: Suppl. 51, 138s
Year: 2007

Compound A modulates steroid insensitive chemokines in airway smooth muscle cells via IRF-1 dependent and independent pathways
Source: International Congress 2015 – New targets and modalities for the treatment of asthma and COPD
Year: 2015

Heme-oxygenase (HO)-1 inhibits TNF-α induced CXCL10 secretion by airway smooth muscle cells
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Glutathionylation of IκB-α inhibits NF-κB dependent chemokine secretion in airway smooth muscle cells
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010