A soluble guanylate cyclase stimulator, BAY 41-8543, preserves pulmonary artery endothelial function in experimental pulmonary embolism

J. Watts, M. Gellar, M. B. Fulkerson, H. Quach, J. Kline (Charlotte, Indianapolis, United States Of America)

Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Session: Pulmonary circulation: animal models and experimental treatments
Session type: Poster Discussion
Number: 490
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J. Watts, M. Gellar, M. B. Fulkerson, H. Quach, J. Kline (Charlotte, Indianapolis, United States Of America). A soluble guanylate cyclase stimulator, BAY 41-8543, preserves pulmonary artery endothelial function in experimental pulmonary embolism. Eur Respir J 2013; 42: Suppl. 57, 490

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Effects of a soluble guanylate cyclase stimulator, BAY 41-8543, upon right ventricular function in experimental pulmonary embolism
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012


Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Source: Eur Respir J 2008; 32: 881-891
Year: 2008



Anti-remodeling potencies of the soluble guanylate cyclase activator BAY 41-2272 in human lung fibroblasts
Source: International Congress 2014 – Pulmonary hypertension: improving treatment in PAH
Year: 2014

Selective inhibition of neutrophil elastase by BAY 85-8501 improves exercise capacity and pulmonary hypertension in a porcine pancreatic elastase-induced emphysema model
Source: International Congress 2014 – Pulmonary hypertension: improving treatment in PAH
Year: 2014

Soluble guanylate cyclase stimulation: an emerging option in pulmonary hypertension therapy
Source: Eur Respir Rev 2009; 18: 35-41
Year: 2009


Pharmacokinetics of the soluble guanylate cyclase stimulator riociguat in individuals with renal impairment
Source: Annual Congress 2013 –Pulmonary circulation: clinical treatment
Year: 2013

Effect of POL6014, a protein epitope mimetic (PEM) neutrophil elastase inhibitor, in a model of monocrotaline (MCT)-induced pulmonary arterial hypertension in rats
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013

First acute haemodynamic study of soluble guanylate cyclase stimulator riociguat in pulmonary hypertension
Source: Eur Respir J 2009; 33: 785-792
Year: 2009



Human apyrase (APT102) treatment attenuates the development of severe pulmonary arterial hypertension (PAH)
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013


Blunted effects of rho-kinase inhibitor, fasudil, on pulmonary arterial pressure in Yak, a high altitude-adapted animal
Source: Annual Congress 2013 –Pulmonary circulation: animal models and experimental treatments
Year: 2013

Riociguat: an upcoming therapy in chronic thromboembolic pulmonary hypertension?
Source: Eur Respir Rev 2009; 19: 68-71
Year: 2010



Hemodynamic and anti-remodelling effect of the Rho kinase inhibitor Y-27632 in the monocrotaline pulmonary arterial hypertension rat model
Source: International Congress 2016 – The nature of pulmonary hypertension
Year: 2016


Activation of AMPK inhibits pulmonary arterial remodeling
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

The role of soluble guanylyl cyclase in chronic obstructive pulmonary disease
Source: Annual Congress 2013 –Emerging new targets for the treatment of respiratory diseases
Year: 2013



Riociguat for interstitial lung disease and pulmonary hypertension: a pilot trial
Source: Eur Respir J 2013; 41: 853-860
Year: 2013



Prevention of monocrotaline-induced pulmonary vascular and myocardial remodeling by the selective neutrophil elastase inhibitor BAY 85-8501
Source: International Congress 2014 – Pulmonary hypertension: novel targets and drugs
Year: 2014

Modulation of symmetric dimethyarginine formation by apelin in human pulmonary endothelial cells
Source: International Congress 2015 – Translational research in respiratory care: new findings
Year: 2015

Role of the TrkA receptor in experimental severe pulmonary hypertension
Source: International Congress 2015 – Pulmonary hypertension: promising small molecules
Year: 2015

Repeated embolization and fibrinolysis inhibition induce chronic thromboembolic pulmonary hypertension in rabbits
Source: Annual Congress 2013 –Pulmonary circulation: chronic thromboembolic pulmonary hypertension, imaging and biomarkers
Year: 2013

Anti-contractile and anti-proliferative responses in human pulmonary arterial smooth muscle cells induced by ACT-333679, the active metabolite of selexipag, a non-prostanoid selective prostacyclin receptor agonist
Source: International Congress 2014 – Pulmonary hypertension: novel targets and drugs
Year: 2014