Epidermal growth factor (EGF) and its receptors (ERBBs) in smokers with and without COPD: An index of epithelial repair imbalance?

A. Anagnostis, E. Neofytou, N. Soulitzis, M. Avgousti, C. Stroumpos, I. Drositis, N. Siafakas, E. Tzortzaki (Heraklion, Greece)

Source: Annual Congress 2012 - The smoking gun in COPD biology
Session: The smoking gun in COPD biology
Session type: Poster Discussion
Number: 4585
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Anagnostis, E. Neofytou, N. Soulitzis, M. Avgousti, C. Stroumpos, I. Drositis, N. Siafakas, E. Tzortzaki (Heraklion, Greece). Epidermal growth factor (EGF) and its receptors (ERBBs) in smokers with and without COPD: An index of epithelial repair imbalance?. Eur Respir J 2012; 40: Suppl. 56, 4585

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Expression of transforming growth factor (TGF) in bronchial epithelium: association with COPD
Source: Eur Respir J 2001; 18: Suppl. 33, 92s
Year: 2001

Epidermal growth factor receptor (EGFR) overexpression in human bronchial epithelial cells amplifies IL-8 release provoked by cigarette smoke and bacterial surrogates
Source: Eur Respir J 2005; 26: Suppl. 49, 441s
Year: 2005

Expression of basic fibroblast growth factor (bFGF) in smokers with COPD
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

Expression of vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) as a prognostic factor of survival in patients with lung adenocarcinoma
Source: Annual Congress 2008 - Management, quality aspects and prognosis in thoracic oncology
Year: 2008


Transforming Growth factor beta-1 and Smad signaling has the potential to drive EMT-related changes in smokers and COPD
Source: International Congress 2016 – How the understanding og molecular and genomic crosstalk is helping to diagnose lung disease
Year: 2016

The contribution of transforming growth factor-β and epidermal growth factor signalling to airway remodelling in chronic asthma
Source: Eur Respir J 2006; 27: 208-229
Year: 2006



Epidermal growth factor receptor (EGFR) activation is required for TGFbeta1-induced epithelial-mesenchymal transition (EMT) in idiopathic pulmonary fibrosis (IPF)
Source: Annual Congress 2013 –Growth factors at the crossroads of acute and chronic inflammation
Year: 2013

Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) expression in NSCLC
Source: Eur Respir J 2005; 26: Suppl. 49, 459s
Year: 2005

Vascular endothelial growth factor (VEGF) is a predictable marker for FEV1 progression in patients with Lymphangiolyomyomatosis (LAM).
Source: International Congress 2019 – Innovative approaches for management and treatment of rare diffuse parenchymal lung diseases
Year: 2019


A role for the accessory type III transforming growth factor β receptor (Tgfbr3) in lung alveolarisation
Source: International Congress 2016 – Common mechanisms in lung development and fibrosis
Year: 2016

Expression of epidermal growth factor receptor (EGFR) in the bronchial epithelium of patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2011 - COPD: clinical studies and animal cell models
Year: 2011

TGF-β receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
Source: Eur Respir J 2008; 32: 285-295
Year: 2008



Vascular endothelial growth factor (VEGF) and its receptors (VEGF-R1-Flt-1, VEGF-R2-KDR/Flk-1) as prognostic indicators in small cell lung carcinomas (SCLC)
Source: Annual Congress 2007 - Diagnosis and prognosis in thoracic oncology
Year: 2007


Oral presentation: Influenza virus (IV) impairs fibroblast growth factor receptor 2b (FGFR2b) dependent epithelial regeneration from a distal epithelial progenitor pool
Source: Lung Science Conference 2014 - Lung Inflammation and Immunity
Year: 2014

Epidermal growth factor receptor signalling contributes to house dust mite-induced epithelial barrier dysfunction
Source: Eur Respir J 2010; 36: 1016-1026
Year: 2010



Transforming growth factor beta (TGF-β) augments rhinovirus (RV) replication in primary bronchial epithelial cells (pbecs) through modulation of the innate immune response
Source: Annual Congress 2009 - Viruses and respiratory infections: prevalence and mechanisms of infection
Year: 2009


ErbB receptor regulation by dexamethasone in mouse type II epithelial cells
Source: Eur Respir J 2006; 28: 1117-1123
Year: 2006



Expression of transforming growth factors beta (1, 2, 3) and connective tissue growth factor in the peripheral lung from GOLD stage 1-2 COPD patients and smokers with normal lung function
Source: Eur Respir J 2006; 28: Suppl. 50, 663s
Year: 2006