Sphingosine kinase-1 and sphingosine-1-phosphate promote the development of acute lung injury in pneumoccocal pneumonia

B. Gutbier, S. M. Schönrock, R. Haberberger, A. C. Hocke, S. Hippenstiel, A. Lüth, B. Kleuser, W. G. Bertrams, K. Szymanski, K. Reppe, H. C. Müller-Redetzky, B. Schmeck, M. Andratsch, T. J. Mitchell, H. Schütte, K. Mayer, N. Suttorp, M. Witzenrath, Capnetz Study Group (Berlin, , Marburg, Gießen, Hannover, Germany; Adelaide, Australia; , Austria; , United Kingdom)

Source: Annual Congress 2012 - Novel mechanisms of acute lung injury
Session: Novel mechanisms of acute lung injury
Session type: Oral Presentation
Number: 4319
Disease area: Respiratory infections

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
B. Gutbier, S. M. Schönrock, R. Haberberger, A. C. Hocke, S. Hippenstiel, A. Lüth, B. Kleuser, W. G. Bertrams, K. Szymanski, K. Reppe, H. C. Müller-Redetzky, B. Schmeck, M. Andratsch, T. J. Mitchell, H. Schütte, K. Mayer, N. Suttorp, M. Witzenrath, Capnetz Study Group (Berlin, , Marburg, Gießen, Hannover, Germany; Adelaide, Australia; , Austria; , United Kingdom). Sphingosine kinase-1 and sphingosine-1-phosphate promote the development of acute lung injury in pneumoccocal pneumonia. Eur Respir J 2012; 40: Suppl. 56, 4319

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Chronic stress affects lung sphingosine kinase isoenzymes and increases the risk of lung infections
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010

Role of angiopoietins Ang-1 and Ang-2 for the development of acute lung injury in pneumococcal pneumonia
Source: Annual Congress 2011 - Assessment of severity and predictors of outcomes in community-acquired pneumonia
Year: 2011

Ethyl pyruvate prevents lung injury through inhibition of the NF-kappa B pathway, but does not prevent bleomycin-induced lung injury
Source: Annual Congress 2010 - New insights into reactive oxygen species
Year: 2010


Effect of tyrosine kinase inhibitors, imatinib and nilotinib, in murine lipopolysaccharide-induced acute lung injury during neutropenia recovery
Source: Annual Congress 2013 –Experimental models in critical care
Year: 2013



Inhibition of neutrophil apoptosis by sphingosin-1-phopsphate through the activation of neutral sphingomyelinase in acute lung injury
Source: Annual Congress 2010 - Emerging mechanisms in lung injury
Year: 2010

Creatine supplementation inhibits acute lung injury induced by pulmonary ischemia-reperfusion
Source: Annual Congress 2010 - Determinants of acute lung injury and fibrosis
Year: 2010


Effect of phosphodiesterase-4 inhibitor on the inflammation, oxidative damage and apoptosis in a saline lavage-induced model of acute lung injury
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



p38 MAP kinase mediates apoptosis related to ventilator associated lung injury
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008

Preventive and therapeutic effects of phosphoinositide 3-kinase inhibitors on acute lung injury
Source: Annual Congress 2011 - Anti-inflammatory strategies in acute lung injury
Year: 2011

Role of syndecan-4 in acute lung inflammation
Source: Annual Congress 2010 - Novel markers of lung injury
Year: 2010


Rho-kinase inhibitor ameliorates bleomycin-induced chronic lung injury in neonatal rats
Source: Annual Congress 2011 - Issues in paediatric and neonatal intensive care
Year: 2011

Dexamethasone inhibits secretory and cytosolic phospholipases A2 in alveolar macrophages in acute lung injury
Source: Annual Congress 2013 –Macrophages, mononuclear cells and viral infection
Year: 2013

Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease
Source: Eur Respir J, 58 (2) 2000752; 10.1183/13993003.00752-2020
Year: 2021



Syndecan-1 attenuates lung injury during influenza infection by activating survival signals via c-Met
Source: Lung Science Conference 2015
Year: 2015


Neutralizing the complement component C5a protects against lung injury and extrapulmonary organ injury in pneumococcal pneumonia induced sepsis
Source: International Congress 2014 – Critical illness and therapeutic interventions
Year: 2014

A role for PAR1 in lipopolysaccharide induced acute lung injury
Source: Annual Congress 2008 - Vascular and interstitial remodelling in chronic lung disease: therapeutic interventions on the horizon
Year: 2008

Ventilator-induced lung injury in severe pneumococcal pneumonia: Protection by adrenomedullin
Source: Annual Congress 2012 - Novel mechanisms of acute lung injury
Year: 2012

PD98059 attenuates the development of bleomycin-induced lung injury and fibrosis
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Airway sphingomyelinase, ceramide pathway and apoptosis in lung disease
Source: Eur Respir J 2005; 26: Suppl. 49, 20s
Year: 2005

Role of FMS-like tyrosine kinase-3 ligand elicited dendritic cell subsets in acute lung injury in response to S. pneumoniae infection
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010