Increased activity of Lyn tyrosine kinase causes multiple chronic obstructive pulmonary disease-like changes in mouse

W. L. Lau, E. Duan, J. L. McQualter, G. P. Anderson, M. L. Hibbs (Melbourne, Australia)

Source: Annual Congress 2012 - New biomarkers for lung cancer
Session: New biomarkers for lung cancer
Session type: Thematic Poster Session
Number: 4222
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
W. L. Lau, E. Duan, J. L. McQualter, G. P. Anderson, M. L. Hibbs (Melbourne, Australia). Increased activity of Lyn tyrosine kinase causes multiple chronic obstructive pulmonary disease-like changes in mouse. Eur Respir J 2012; 40: Suppl. 56, 4222

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Inhibition of c-kit tyrosine kinase by sunitinib alleviates airway remodeling in a mouse model of chronic asthma
Source: Annual Congress 2009 - Preclinical models in drug development
Year: 2009



The role of tyrosine kinases in the pathogenesis of idiopathic pulmonary fibrosis
Source: Eur Respir J 2015; 45: 1426-1433
Year: 2015



Btk (Bruton’s tyrosine kinase) in B cells is overexpressed in patients with idiopathic pulmonary arterial hypertension
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Increased activation of p38 MAPK in COPD
Source: Eur Respir J 2008; 31: 62-69
Year: 2008



Epigenetic-like regulation of signalling proteins in chronic obstructive pulmonary disease
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019


Targeting the mTOR signaling pathway to inhibit lung cell senescence in chronic obstructive pulmonary disease (COPD)
Source: ERS Lung Science Conference 2017
Year: 2017

Pulmonary complications of tyrosine kinase inhibitors in myeloproliferative disorders
Source: Eur Respir J, 56 (4) 2002653; 10.1183/13993003.02653-2020
Year: 2020



Chronic stress affects lung sphingosine kinase isoenzymes and increases the risk of lung infections
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010

PP208 – SRC family kinases modulate molecular pathways associated with mitochondrial dysfunction in idiopathic pulmonary fibrosis
Source: ERS Lung Science Conference 2021
Year: 2021

Plasma receptor tyrosine kinase RET in pulmonary arterial hypertension diagnosis and differentiation
Source: ERJ Open Res, 5 (4) 00037-2019; 10.1183/23120541.00037-2019
Year: 2019



Anti IL-17 with or without Rho kinase inhibitor in mice with chronic allergic pulmonary inflammation
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

Expression of the MET receptor kinase is a potential functional marker of Idiopathic pulmonary fibrosis
Source: International Congress 2017 – Novel pro- and anti-fibrotic mechanisms in pulmonary fibrosis
Year: 2017

Homeodomain-interracting protein kinase 2 (HIPK2) in idiopathic pulmonary fibrosis
Source: Annual Congress 2010 - Clinical aspects in pulmonary fibrosis
Year: 2010


Role of IκB kinases (IKKs) α and β in severe asthma and COPD
Source: Eur Respir J 2005; 26: Suppl. 49, 2s
Year: 2005

Increased rho-kinase activity is related to pulmonary endothelial dysfunction in patients with chronic obstructive pulmonary disease (COPD)
Source: Annual Congress 2008 - Pulmonary vascular biology
Year: 2008


Corticosteroid insensitivity and enhanced mitogen-activated protein kinase activity in airway smooth muscle cells of severe asthma
Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology
Year: 2011


Mice deficient in Raf kinase inhibitor protein (RKIP) have elevated indices of pulmonary hypertension
Source: Annual Congress 2010 - Experimental pulmonary hypertension
Year: 2010

Involvement of cytoskeletal protein paxillin in the pathogenesis of pulmonary hypertension
Source: Annual Congress 2011 - Experimental pulmonary hypertension
Year: 2011

SRC family kinase inhibition reduces NOX4 expression in bronchial epithelial cells from Idiopathic Pulmonary Fibrosis patients
Source: International Congress 2019 – Damage and remodelling in pulmonary fibrosis
Year: 2019