Source: Annual Congress 2012 - Cellular signalling mechanisms in the airways
Disease area: Airway diseases



Rating:

Share or cite this content

Citations should be made in the following way:
Y. Kobayashi, N. Mercado, A. Miller-Larsson, P.J. Barnes (London, United Kingdom; Molndal, Sweden). Formoterol restores oxidative stress-induced corticosteroid insensitivity via activation of protein phosphatase PP2A. Eur Respir J 2012; 40: Suppl. 56, 3417

Member's Comments

No comment yet.

Related content which might interest you: Protein phosphatase PP2A activation by formoterol reverses corticosteroid insensitivity Source: Annual Congress 2009 - Airway cell biology Year: 2009 Activated protein phosphatase PP2A by formoterol enhances nuclear translocation of glucocorticoid receptor induced by budesonide Source: Annual Congress 2011 - Models of disease and drug actions Year: 2011 A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via activation of protein phosphatase PP2A Source: Annual Congress 2011 - Phagocytes and dendritic cells Year: 2011 Pharmacological induction of HDAC activity restores steroid function in macrophages subjected to oxidative stress Source: Eur Respir J 2005; 26: Suppl. 49, 214s Year: 2005 Corticosteroid insensitivity and enhanced mitogen-activated protein kinase activity in airway smooth muscle cells of severe asthma Source: Annual Congress 2011 - Airway smooth muscle cells and fibroblasts: cell biology Year: 2011 Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma Source: Eur Respir J 2010; 35: 750-756 Year: 2010 Oxidative stress-mediated decrease in histone deacetylase activity is attenuated by N-acetyl-L-cysteine but not by Iκ-B kinase inhibition in alveolar epithelial cells Source: Eur Respir J 2004; 24: Suppl. 48, 29s Year: 2004 Impaired protein tyrosine phosphatase PTPRR reduces response to corticosteroid in mononuclear cells Source: Annual Congress 2013 –Asthma: new mechanisms and markers Year: 2013 MAP kinase phosphatase 1 mediates glucocorticoid inhibition of CD38 expression in human airway smooth muscle Source: Annual Congress 2008 - Basic science in asthma and COPD II Year: 2008 Oxidative stress-induced corticosteroid insensitivity is reversed by formoterol via inhibition of PI3K signalling in peripheral blood mononuclear cells from patients with COPD and severe asthma Source: Annual Congress 2011 - Models of disease and drug actions Year: 2011 Erythromycin restores HDAC2 levels diminished under oxidative and inflammatory stress in vitro and in vivo Source: Annual Congress 2008 - Pathogenesis and treatment of asthma and COPD Year: 2008 Effect of PDE4 inhibitors on MAPK activation and IL-8 production on A549 cells following the induction of oxidative stress Source: Eur Respir J 2005; 26: Suppl. 49, 99s Year: 2005 Oxidative stress induces arachidonic acid release from human lung cells through the EGFR pathway leading to cPLA2 phosphorylation Source: Annual Congress 2003 - Intracellular signalling and regulation of cytokine production Year: 2003 DJ-1 and its anti-oxidative stress response regulates the expression of sirtuin-1 in COPD epithelial cells Source: International Congress 2017 – Translational studies of lung disease Year: 2017 MAPK inhibition modulates Hsp27 phosphorylation and glutathione in lung epithelial cells Source: Eur Respir J 2006; 28: Suppl. 50, 192s Year: 2006 Inhibition of ER stress suppresses IL-13 induced airway epithelial remodeling Source: International Congress 2019 – COPD, asthma and rhinitis: from cellular mechanisms to patients’ clinical responses Year: 2019 Inhibition of c-kit tyrosine kinase by sunitinib alleviates airway remodeling in a mouse model of chronic asthma Source: Annual Congress 2009 - Preclinical models in drug development Year: 2009 iNOS inhibition modulates lung tissue inflammation via oxidative stress pathway activation Source: Annual Congress 2008 - Inflammatory trigger mechanisms in asthma and COPD Year: 2008 SH2 domain-containing Phosphatase-(SHP)-2 blunts fibrotic responses through regulation of fibroblast mitochondrial metabolism and autophagy Source: International Congress 2019 – Extracellular matrix formation and remodelling in physiology and disease Year: 2019 The RNA binding protein HuR regulates the senescence-associated secretory phenotype under conditions of oxidative stress Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease Year: 2019