Eosinophil adhesion to cholinergic nerve cells induces NFκB activation via the interleukin-1 receptor associated kinase (IRAK) pathway and upregulates ICAM-1 expression Source: Eur Respir J 2003; 22: Suppl. 45, 10s Year: 2003
Thrombin activates mitogen activated protein (MAP) kinase and activated protein-1 (AP-1) to induce interleukin-8 (IL-8) release from airway epithelial cells Source: Annual Congress 2003 - Mechanisms of lung injury: from bench to bedside Year: 2003
Stimulation of NOD1 induces RIP2, TAK1 and p38 MAPK dependent pro-inflammatory signalling in human lung microvascular endothelial cells Source: Annual Congress 2011 - Mechanisms of acute lung injury and mesenchymal cell treatment Year: 2011
Activation of protease-activated receptor 2 elicits epithelial-mesenchymal transition in HBE cells via ROS signaling Source: International Congress 2017 – Therapeutic approaches in lung disease Year: 2017
G-protein mediated EGFR transactivation induces mucin production Source: Annual Congress 2003 - Cellular and molecular mechanisms in epithelium injury and repair Year: 2003
Thrombin induces collagen gel contraction partially through PAR1 activation and PKC-{epsilon} Source: Eur Respir J 2004; 24: 918-924 Year: 2004
Endothelin-1 activates pro-inflammatory signalling pathway via destinct p38MAPK isoforms resulting in downregulation of nuclear p27kip1 Source: Annual Congress 2009 - Airway cell biology Year: 2009
Transmission of muscarinic receptor mediated proliferative effects in human lung fibroblasts involves ERK-MAP kinase, but not PI-3 kinase and Rho-kinase pathway Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology Year: 2007
Human rhinovirus induces the expression of the membrane bound form of its cellular receptor intercellular adhesion molecule 1via a tyrosine kinase dependent signal transduction pathway Source: Eur Respir J 2001; 18: Suppl. 33, 160s Year: 2001
Protease activated receptor 2 (PAR2) antagonism reduces pro-inflammatory cytokine production in bronchial epithelial cells Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies Year: 2020
Thrombin induces epithelial-mesenchymal transition via PAR1, PKC and ERK1/2 pathways in A549 cells Source: Annual Congress 2012 - Diffuse parenchymal lung disease pathogenesis, biomarkers, therapy and new entities Year: 2012
Endotoxin induces proliferation of NSCLC cells by a COX-2 dependent manner – Role of CD14, TLRs and EGFR signaling Source: Annual Congress 2010 - Pathology of lung cancer Year: 2010
Thrombin induces stomatin-like protein 2 (STOML2) expression and IL-8/CXCL8 release by ROCK, JNK, and PEA3 pathways in human lung epithelial cells Source: Virtual Congress 2020 – Asthma science: novel targets and mechanisms Year: 2020
Autocrine secretion of bradykinin prevents alveolar type II cells from mechanical stretch-induced apoptosis by activation – role of PI3K and Akt Source: Annual Congress 2008 - Border patrol: the alveolar barrier in lung injury Year: 2008
Extracellular ATP is a danger signal activating P2X7 Receptor in a LPS mediated inflammation (ARDS/ALI) Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease Year: 2019
TNF-α inhibits human eosinophil apoptosis by activating p55 receptor and NF-κB Source: Eur Respir J 2001; 18: Suppl. 33, 162s Year: 2001
MMP-12 activates protease activated receptor (PAR)-1, upregulates placenta growth factor and leads to pulmonary emphysema Source: International Congress 2018 – COPD: novel pathological mechanisms in the airway epithelium Year: 2018
Gene transfer of a β-adrenergic receptor kinase inhibitor up-regulated levels of β-adrenergic receptor and cAMP in asthmatic murine lung Source: Eur Respir J 2005; 26: Suppl. 49, 580s Year: 2005
Pneumolysin mediates neutrophil:platelet aggregation via a P-selectin- and protease-activated receptor-1 (PAR-1)-dependent mechanism Source: International Congress 2017 – How can microbiology and translational research help physicians? Year: 2017
Protease-activated receptor 2 (PAR2) stimulation potentiates citric acid induced cough by sensitising the vanilloid receptor-1 (TRPV1) Source: Annual Congress 2003 - Novel drugs under development for the treatment of respiratory diseases Year: 2003