Statins worse pulmonary fibrosis through enhancing NLRP3 inflammasome activation

J.F. Xu, G.R. Washko, H.P. Li, A.M.K. Choi, G.M. Hunninghake (Shanghai, China; Boston, United States Of America)

Source: Annual Congress 2012 - Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Session: Animal models of asthma and COPD and late-breaking abstracts on RCT in asthma and COPD
Session type: Thematic Poster Session
Number: 2125
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
J.F. Xu, G.R. Washko, H.P. Li, A.M.K. Choi, G.M. Hunninghake (Shanghai, China; Boston, United States Of America). Statins worse pulmonary fibrosis through enhancing NLRP3 inflammasome activation. Eur Respir J 2012; 40: Suppl. 56, 2125

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A role for the inflammasome effector caspase-1 in hypoxia-induced pulmonary hypertension
Source: International Congress 2017 – Experimental PH
Year: 2017


Andrographolide inhibits the activation of NLRP3 inflammasome in patients with COPD
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018



The activation of NLRP3 inflammasome pathway in COPD is limited in local airways
Source: International Congress 2018 – Disease exacerbations from a molecular point of view
Year: 2018




NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung
Source: Eur Respir J 2016; 47: 910-918
Year: 2016



Tetracycline alleviates acute lung injury by inhibition of NLRP3 inflammasome
Source: International Congress 2019 – ECMO, ECCO2R and other rescue therapies in acute respiratory failure
Year: 2019

The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation
Source: Eur Respir J, 55 (3) 1900119; 10.1183/13993003.00119-2019
Year: 2020



Role of the inflammasome in idiopathic pulmonary fibrosis
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017

NLRP3 inflammasome conjugates with mitochondria in LPS-induced acute lung injury
Source: Virtual Congress 2020 – Cellular stress in respiratory diseases
Year: 2020


Elevated expression of the NLRP3 inflammasome in neutrophilic asthma
Source: Eur Respir J 2014; 43: 1067-1076
Year: 2014



Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD
Source: Annual Congress 2013 –Predictors and triggers of asthma and COPD exacerbations
Year: 2013

Activation of NLRP3 inflammasome is regulated by mitochondrial ROS via PI3K-HIF-VEGF pathway in acute lung injury
Source: International Congress 2015 – Novel insights into the pathobiology of acute lung injury
Year: 2015


FIZZ1: a new pathway in silica-induced inflammatory mediators and pulmonary fibrosis
Source: International Congress 2018 – Occupational and environmental lung diseases: mechanisms, biomarkers and causation
Year: 2018

Activation of the inflammasome pathway during exacerbations of COPD
Source: Annual Congress 2011 - Recent developments in COPD
Year: 2011


TRIM33 prevents pulmonary fibrosis by impairing TGF-ß1 signalling
Source: Eur Respir J, 55 (6) 1901346; 10.1183/13993003.01346-2019
Year: 2020



Defective p53-mediated pro-apoptotic pathway in idiopathic pulmonary fibrosis
Source: Annual Congress 2008 - New insights into the pathogenesis of idiopathic pulmonary fibrosis and sarcoidosis
Year: 2008

The NLRP3 inflammasome in chronic obstructive pulmonary disease
Source: Annual Congress 2013 –COPD: experimental biology
Year: 2013


Impaired lung function is associated with systemic inflammation and macrophage activation
Source: Eur Respir J 2015; 45: 557-559
Year: 2015


Cigarette smoke extract inhibits the NLRP3 inflammasome in human macrophages and impairs cell metabolism via NLRP3-independent activation of Caspase-1
Source: International Congress 2019 – Effects of environmental exposures in lung pathology and the underlying mechanisms
Year: 2019

6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway
Source: Virtual Congress 2020 – Translational therapeutic advances
Year: 2020


NLRP3 inflammasome is activated via phosphoinositide 3-kinase δ pathway in Aspergillus fumigatus-induced allergic airway inflammation
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015