Genetic variations in the TLR signaling pathway are associated with childhood asthma

R.C. Pandey, S. Michel, R. Tesse, A. Binia, M. Schedel, L. Liang, N. Klopp, E. von Mutius, A. von Berg, A. Bufe, E. Rietschel, A. Heinzmann, O. Laub, B. Simma, T. Frischer, J. Genuneit, T. Illig, M. Kabesch (Hanover, Neuherberg, Munich, Wesel, Bochum, , Freiburg, Rosenheim, Ulm, Germany; Boston, United States Of America; Feldkirch, Vienna, Austria)

Source: Annual Congress 2012 - Asthma and the genes: from GWAS to next generation transcriptome analyses
Session: Asthma and the genes: from GWAS to next generation transcriptome analyses
Session type: Oral Presentation
Number: 1866
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
R.C. Pandey, S. Michel, R. Tesse, A. Binia, M. Schedel, L. Liang, N. Klopp, E. von Mutius, A. von Berg, A. Bufe, E. Rietschel, A. Heinzmann, O. Laub, B. Simma, T. Frischer, J. Genuneit, T. Illig, M. Kabesch (Hanover, Neuherberg, Munich, Wesel, Bochum, , Freiburg, Rosenheim, Ulm, Germany; Boston, United States Of America; Feldkirch, Vienna, Austria). Genetic variations in the TLR signaling pathway are associated with childhood asthma. Eur Respir J 2012; 40: Suppl. 56, 1866

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Notch pathway signaling in asthma
Source: Annual Congress 2006 - Markers of paediatric airway disease
Year: 2006


Analysis of cytokine signaling pathway JAK-STAT through their activation in patients with asthma
Source: Annual Congress 2008 - Novel mechanisms and targets of molecular pulmonary pathology
Year: 2008


Genetic association studies between the MyD88 adaptor pathway SNPs and the development of tuberculosis
Source: Annual Congress 2011 - Tuberculosis: from bench to bedside
Year: 2011


Hedgehog pathway activation is altered in COPD patients
Source: International Congress 2019 – Cellular responses and cell therapy in lung injury and repair
Year: 2019


Genetic association studies between the myd88 adaptor pathway SNPs and the development of sarcoidosis
Source: Annual Congress 2009 - Sarcoidosis in review
Year: 2009


Glucocorticoid signaling genes are altered in asthma subgroups – A potential role for mRNA-miRNA interactions
Source: Virtual Congress 2020 – Intercellular communication in tissue remodelling of chronic lung diseases
Year: 2020


Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk
Source: Annual Congress 2008 - Risk factors for allergic asthma and allergic rhinitis
Year: 2008


Temporal analysis of the intracellular signaling pathways involved in Th17/Treg response in COPD development
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of COPD
Year: 2019


Decreased Wnt/β-catenin signaling in COPD: Possible involvement of Wnt antagonists
Source: Annual Congress 2012 - New mechanisms in non-neoplastic and neoplastic lung diseases
Year: 2012

Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011


Maternal genetic asthma predisposition affects signaling networks in lungs of neonatal offspring
Source: Annual Congress 2012 - Predicting and observing paediatric allergic disease
Year: 2012


Relation of genetic polymorphisms inflammatory pathway genes with occupational chronic bronchitis susceptibility
Source: Annual Congress 2010 - Chemical exposures and respiratory effects
Year: 2010


Toll-like receptors and microbial exposure: gene–gene and gene–environment interaction in the development of atopy
Source: Eur Respir J 2011; 38: 833-840
Year: 2011



Inhibition of VEGF blocks the activation of TGF-β1 through a PI3K/Akt signaling pathway in allergic airway disease of mice
Source: Annual Congress 2007 - Current issues in airway physiology, pharmacology and monitoring
Year: 2007


A comprehensive analysis of toll-like receptor 1-10 polymorphisms and their role in childhood asthma
Source: Eur Respir J 2006; 28: Suppl. 50, 257s
Year: 2006

Activation of TGFβ/Smad signalling pathway in induced sputum of asthmatic children
Source: Annual Congress 2009 - Novel mechanisms in the pathogenesis of asthma
Year: 2009

Novel polymorphisms in the T-bet gene are associated with childhood asthma
Source: Eur Respir J 2004; 24: Suppl. 48, 135s
Year: 2004

Cigarette smoke causes increased susceptibility to respiratory pathogens: role for innate immunity toll-like receptor (TLR4) inactivation
Source: Eur Respir J 2006; 28: Suppl. 50, 853s
Year: 2006

The KEAP1/NRF2 signaling system genes and theirs target genes are associated with COPD
Source: International Congress 2018 – Functional genomics and COPD: new challenges
Year: 2018


Enhanced efficiency of phenotypic transition of asthmatic fibroblasts depends on canonical and non-canonical TGFß/Smad signaling pathways
Source: International Congress 2018 – Identification of therapeutic targets for asthma
Year: 2018