Lack of relevant pharmacokinetic and pharmacodynamic interactions between the new dual endothelin receptor antagonist macitentan and warfarin in healthy subjects

P. Sidharta, H. Dietrich, J. Dingemanse (Allschwil, Switzerland; Cologne, Germany)

Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Session: Pulmonary circulation: clinical PAH, registries and treatments
Session type: Thematic Poster Session
Number: 950
Disease area: Pulmonary vascular diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
P. Sidharta, H. Dietrich, J. Dingemanse (Allschwil, Switzerland; Cologne, Germany). Lack of relevant pharmacokinetic and pharmacodynamic interactions between the new dual endothelin receptor antagonist macitentan and warfarin in healthy subjects. Eur Respir J 2012; 40: Suppl. 56, 950

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Lack of relevant pharmacokinetic interactions between the new dual endothelin receptor antagonist macitentan and sildenafil in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Rising multiple-dose safety and pharmacokinetics of oral SCH 527123, a novel antagonist of CXCR2, in healthy smokers
Source: Annual Congress 2007 - New insights into the treatment of COPD
Year: 2007


Rising single-dose safety and pharmacokinetics of oral SCH 527123, a novel antagonist of CSCR2, in healthy volunteers
Source: Annual Congress 2007 - New insights into the treatment of COPD
Year: 2007


Unique receptor dissociation kinetics of the novel endothelin receptor antagonist macitentan
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Superior in vivo efficacy of macitentan: Comparison to other endothelin receptor antagonists
Source: Annual Congress 2012 - Pulmonary circulation: basic mechanisms, animal models and experimental treatments
Year: 2012

Mutual pharmacokinetic interactions between steady-state bosentan and sildenafil
Source: Eur Respir J 2005; 26: Suppl. 49, 563s
Year: 2005

The safety, tolerability and pharmacokinetics of AZD5069, a novel CXCR2 antagonist, in healthy Japanese volunteers
Source: Annual Congress 2012 - The best of pharmacology treatment for asthma and COPD
Year: 2012

Characterising the cardiovascular safety profile of inhaled muscarinic receptor antagonists
Source: Eur Respir Monogr 2020; 88: 238-250
Year: 2020


Preclinical safety profile of oral SCH 527123, a novel antagonist of CXCR2
Source: Annual Congress 2007 - Miscellaneous pulmonary pharmacology II
Year: 2007


In vitro pharmacological profile of CHF 5407, a potent, long-acting and selective muscarinic M3 receptor antagonist
Source: Eur Respir J 2007; 30: Suppl. 51, 25s
Year: 2007

Efficacy of sitaxsentan, an endothelin-A receptor antagonist in PAH in traditional vs. expanded study populations
Source: Eur Respir J 2004; 24: Suppl. 48, 109s
Year: 2004

‘Total PDE4 inhibitory activity‘: a concept for evaluating pharmacokinetic alterations of roflumilast and roflumilast N-oxide in special populations and drug-drug interactions
Source: Eur Respir J 2006; 28: Suppl. 50, 436s
Year: 2006

Safety and pharmacokinetics of aclidinium bromide, a novel, long-acting muscarinic antagonist, in renally impaired subjects
Source: Annual Congress 2009 - Next generation bronchodilators
Year: 2009


A novel dual-agonist challenge model in guinea pigs for assessment of individual and combined muscarinics antagonists and b2 adrenoceptor agonists bronchodilator efficacy
Source: Annual Congress 2011 - Models of disease and drug actions
Year: 2011

GB001 is a potent, insurmountable DP2 antagonist with long receptor residence time and extended pharmacodynamic effects
Source: Virtual Congress 2020 – Clinical and laboratory pharmacology in asthma
Year: 2020


The pre-clinical pharmacology of the inhaled muscarinic antagonist GSK573719 predicts once-daily clinical dosing
Source: Annual Congress 2011 - Understanding disease and drug mechanisms
Year: 2011

The dual endothelin receptor antagonist bosentan reduces TNFα induced GM-CSF release more effectively than the endothelin A receptor antagonist ambrisentan
Source: Annual Congress 2010 - Airway smooth muscle cells
Year: 2010

Safety, tolerability and pharmacokinetics (PK) of repeated doses of GSK573719 inhalation powder, a new long-acting muscarinic antagonist, in healthy adults
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011

A novel lung pharmacokinetic model predicts lung exposure and supports dose selection for clinical study of AZD2115, a dual muscarinic receptor antagonist/beta2 adrenoceptor agonist (MABA)
Source: International Congress 2015 – Notable abstracts in exacerbations, mechanisms and biomarkers in COPD
Year: 2015


No relevant pharmacokinetic drug–drug interaction between nintedanib and pirfenidone
Source: Eur Respir J, 53 (1) 1801060; 10.1183/13993003.01060-2018
Year: 2019