The toll-like receptor (TLR) 5 ligand, flagellin, prometes asthma by priming allergic responses to indoor allergens

S. Maruoka, R. Wilson, G. Whitehead, J. Foley, G. Flake, M. Sever, D. Zeldin, M. Kraft, S. Garantziotis, S. Hashimoto, H. Nakano, D. Cook (Research Triangle Park, Durham, United States Of America; Tokyo, Japan)

Source: Annual Congress 2011 - Asthma mechanisms
Session: Asthma mechanisms
Session type: Oral Presentation
Number: 4891
Disease area: Airway diseases

Congress or journal article abstractE-posterSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
S. Maruoka, R. Wilson, G. Whitehead, J. Foley, G. Flake, M. Sever, D. Zeldin, M. Kraft, S. Garantziotis, S. Hashimoto, H. Nakano, D. Cook (Research Triangle Park, Durham, United States Of America; Tokyo, Japan). The toll-like receptor (TLR) 5 ligand, flagellin, prometes asthma by priming allergic responses to indoor allergens. Eur Respir J 2011; 38: Suppl. 55, 4891

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge
Source: Eur Respir J 2004; 23: 876-884
Year: 2004



Activation of eosinophils via toll-like receptor (TLR)3, TLR7 and TLR9: link between viral infection and asthma?
Source: Annual Congress 2007 - Novel aspects in airway inflammation in human asthma and rhinitis
Year: 2007



Effects of the novel toll-like receptor 7 (TLR7) agonist AZD8848 on allergen-induced responses in patients with mild asthma
Source: Annual Congress 2012 - New bronchodilators and other novel drugs for asthma and COPD
Year: 2012

Toll-like receptor 7 function is reduced in adolescents with asthma
Source: Eur Respir J 2010; 35: 64-71
Year: 2010



Increased expression of toll-like receptor 2 (TLR2) in the small airways of fatal asthma
Source: Eur Respir J 2007; 30: Suppl. 51, 285s
Year: 2007

Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459
Source: Eur Respir J 2013; 41: 46-52
Year: 2013



LSC 2011 Abstract: An expression survey of toll-like receptors (TLRs) and nod-like receptors (NLRs) in allergic asthma
Source: Annual Congress 2011 - Asthma: basic science and clinical studies
Year: 2011


Toll-like receptor 3 expression in fatal asthma
Source: Annual Congress 2009 - Infections, immunity and inflammation
Year: 2009

Activation of eosinophils via Toll-like receptor (TLR)3, TLR7 and TLR9: link between viral infection and asthma?
Source: Eur Respir Rev 2008; 17: 46-48
Year: 2008



Toll-like receptor 4 expression in the large airways of fatal asthma
Source: Annual Congress 2008 - Understanding the mechanisms and the impact of severe asthma
Year: 2008

Protective effect of a protein epitope mimetic (PEM) CCR10 antagonist, POL7085, in an allergic model of asthma
Source: Annual Congress 2011 - Translational models of airway disease
Year: 2011


Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin
Source: Eur Respir J 2006; 28: 622-626
Year: 2006



A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation
Source: Eur Respir J 2008; 31: 783-789
Year: 2008



Farm dust decreases Th2 driven allergic airway inflammation in mice: A role for airway TLR2 and TLR4?
Source: Annual Congress 2011 - T-cell subsets
Year: 2011


Upregulated response to chemokines in oxidative metabolism of eosinophils in asthma and allergic rhinitis
Source: Eur Respir J 2003; 21: 925-931
Year: 2003



Innate immune response of the lung to bacterial and viral stimuli: evidence for a role of epithelial toll-like receptor (TLR) 4 and TLR3
Source: Eur Respir J 2004; 24: Suppl. 48, 210s
Year: 2004

A pathogen-activated innate homing pathway that instructs allergic inflammation
Source: Annual Congress 2007 - Regulation of allergic airway inflammation in animal models of asthma
Year: 2007


IL-33 augments rhinovirus-induced type 2 immune responses in asthma via selective upregulation of one chain of the IL-33 receptor.
Source: International Congress 2017 – "Alarming" immunological patterns in asthma
Year: 2017


Deletion in macrophage chemokine receptor gene (CCR5) in children with bronchial asthma (BA)
Source: Eur Respir J 2001; 18: Suppl. 33, 450s
Year: 2001