Bitter taste receptors are expressed and induce relaxation of human bronchi Source: Annual Congress 2013 –New drugs in respiratory medicine Year: 2013
Effect of AVE5883, a dual NK1/NK2 receptor antagonist, on airway responsiveness to neurokinin A in asthma Source: Eur Respir J 2004; 24: Suppl. 48, 219s Year: 2004
A novel dual-agonist challenge model in guinea pigs for assessment of individual and combined muscarinics antagonists and b2 adrenoceptor agonists bronchodilator efficacy Source: Annual Congress 2011 - Models of disease and drug actions Year: 2011
Airway responsiveness to beta-adrenergic agonist in smokers Source: Eur Respir J 2004; 24: Suppl. 48, 341s Year: 2004
An oral selective M3 cholinergic receptor antagonist in COPD Source: Eur Respir J 2006 Oct 01;28(4):772-780 Year: 2006
LATE-BREAKING ABSTRACT: The bitter tastants chloroquine and noscapine relax human bronchial smooth muscle by different effects on intracellular calcium signalling Source: International Congress 2014 – Latest insights in airway diseases Year: 2014
In vivo potent and long-lasting bronchodilator activity of muscarinic M3 receptor antagonist CHF5407Source: Eur Respir J 2007; 30: Suppl. 51, 26s Year: 2007
Abediterol has higher bronchodilatory potency than other long-acting beta2 -receptor agonists in a guinea pig model Source: International Congress 2014 – Novel evidence relating to respiratory treatment development Year: 2014
Effects of leukotriene receptor antagonists on airway mucus secretion Source: Eur Respir J 2001; 18: Suppl. 33, 245s Year: 2001
Characterising the cardiovascular safety profile of inhaled muscarinic receptor antagonists Source: Eur Respir Monogr 2020; 88: 238-250 Year: 2020
Mice lacking both M2 and M3 muscarinic receptors display airway hyperresponsiveness (AHR) to serotonin Source: Eur Respir J 2005; 26: Suppl. 49, 714s Year: 2005
Increased airway responsiveness to beta-adrenergic agonists in asthmatic patients Source: Eur Respir J 2005; 26: Suppl. 49, 582s Year: 2005
Dose-related efficacy of GSK573719, a new long-acting muscarinic receptor antagonist (LAMA) offering sustained 24-hour bronchodilation, in COPD Source: Annual Congress 2011 - Bronchodilators in asthma and COPD Year: 2011
Corticosteroid-dependent transcription is reduced by inflammatory stimuli in human airway epithelial cells: Rescue by long-acting β2 -adrenoceptor agonists Source: Annual Congress 2011 - Epithelial cells: role in health and disease Year: 2011
In vitro pharmacological characterization of the novel inhaled bronchodilator CHF6366 acting as dual muscarinic antagonist/ß2-agonist (MABA) Source: International Congress 2017 – Bronchodilators and bronchoprotectors Year: 2017
The dual PDE3/PDE4 phosphodiesterase inhibitor RPL554 produces more complete bronchodilator responses than the beta2-agonist salbutamol and the anti-muscarinic agent ipratropium bromide, alone and in combination, in guinea-pig isolated trachea Source: International Congress 2015 – Novel treatments for cough, asthma, COPD and bronchiectasis Year: 2015
EPAC drives the anti-tussive effect of EP4 receptors on airway sensory nerves Source: Virtual Congress 2020 – Chronic cough: only symptom or disease? Year: 2020
Increased relaxation of immature airways to beta-2 agonists is related to the attenuated expression of postjunctional smooth muscle muscarinic M2 receptors Source: Annual Congress 2004 - Understanding the complexity of how airways are regulated Year: 2004
PF-3429281 – A novel inhaled dual antimuscarinic/β2 adrenoceptor agonist in the anaesthetised dog model of bronchoconstriction Source: Annual Congress 2010 - Bronchodilators in airways disease Year: 2010
Antitussive effect of (-) menthol mediated by nasal trigeminal TRPM8 receptors Source: Annual Congress 2011 - Understanding disease and drug mechanisms Year: 2011