Hypoxia Inducible Factor-1α binding to HDAC2 and MIF promoter regions is associated with changes in gene expression levels in chronic ozone exposed mice

C. Wiegman, K. Russell, C. Clarke, P. Barnes, I. Adcock (London, United Kingdom)

Source: Annual Congress 2011 - Immunology and cell biology of asthma and COPD
Session: Immunology and cell biology of asthma and COPD
Session type: Thematic Poster Session
Number: 3857
Disease area: Airway diseases

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
C. Wiegman, K. Russell, C. Clarke, P. Barnes, I. Adcock (London, United Kingdom). Hypoxia Inducible Factor-1α binding to HDAC2 and MIF promoter regions is associated with changes in gene expression levels in chronic ozone exposed mice. Eur Respir J 2011; 38: Suppl. 55, 3857

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Upregulated HIF (hypoxia inducible factor)-1 DNA binding activity to VEGF-a promoter mediates oedema formation in donor lung grafts
Source: Eur Respir J 2003; 22: Suppl. 45, 7s
Year: 2003

Hypoxia-induced methylation of the Thy-1 promoter is associated with transcriptional repression in human primary lung fibroblasts
Source: Annual Congress 2010 - Recent developments of molecular pathology and functional genomics in non-neoplastic and neoplastic lung diseases
Year: 2010

Common IRF1 promoter polymorphisms induce changes in transcription factor binding subsequently affecting IRF1 gene expression
Source: Annual Congress 2008 - Risk factors for allergic asthma and allergic rhinitis
Year: 2008


Hypoxia inducible factor and gene expression
Source: Annual Congress 2004 - Chronic tissue hypoxia and gene expression: a systems approach to adaptation
Year: 2004

Reduced expression of the transcription factor KLF4 in COPD macrophages is associated with dysfunctional differentiation
Source: International Congress 2017 – Translational studies of lung disease
Year: 2017

Hyperoxia exposure induces age-dependent changes in gene expression in healthy mouse lung
Source: International Congress 2019 – Intercellular communication in tissue remodelling of chronic lung diseases
Year: 2019




Environmental particles (PM10) regulate IL-8 gene expression by oxidative stress-mediated histone acetylation
Source: Eur Respir J 2001; 18: Suppl. 33, 413s
Year: 2001

Polymorphisms in the p53 and p21 promoter are associated with susceptibility to COPD
Source: Eur Respir J 2005; 26: Suppl. 49, 52s
Year: 2005

Epigenetic changes are associated with altered hBD-1 gene expression in patients with COPD
Source: Annual Congress 2008 - Cell biology of asthma and COPD
Year: 2008


IL-13 induces glucocorticoid resistance in iNOS expression and activity in human airway epithelial cells (HAECs)
Source: International Congress 2017 – New insights into pathogenesis of lung disease 
Year: 2017


Suppression of HIF-1a dependent gene regulation by the tumour suppressor gene PTEN in pulmonary cells
Source: Eur Respir J 2001; 18: Suppl. 33, 17s
Year: 2001

Comparison of the gene expression profile in lung fibroblasts from patients with emphysema and changes in gene expression induced by cigarette smoke extract (CSE)
Source: Eur Respir J 2006; 28: Suppl. 50, 585s
Year: 2006

Induced sputum differential gene expression implicates increased p38 signalling activity in severe asthma
Source: Annual Congress 2011 - Molecular: pathology of infectious and inflammatory lung disease
Year: 2011


Glucocorticoid potency correlates with transcriptional induction of a glucocorticoid regulated gene in human monocytes
Source: Eur Respir J 2005; 26: Suppl. 49, 369s
Year: 2005

Cigarette smoke increases histone acetylation in alveolar epithelial cells: a mechanism for enhanced gene expression
Source: Eur Respir J 2002; 20: Suppl. 38, 377s
Year: 2002

Evaluation of mRNA expression profiling of NF-?B mediated signaling in COPD patients.
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020

Transcriptional regulation of IL-4 gene expression
Source: Annual Congress 2004 - Transcription factors in airway disease
Year: 2004

Involvement of RANTES gene promoter polymorphisms in the susceptibility for childhood asthma
Source: Eur Respir J 2005; 26: Suppl. 49, 694s
Year: 2005

Dexamethasone inhibits LPS-induced expression of human β-defensin-2 via down-regulation of TLR4
Source: Eur Respir J 2003; 22: Suppl. 45, 562s
Year: 2003

Increased expression of lymphocyte transcription factor T-bet in COPD
Source: Annual Congress 2009 - COPD: basic science and clinical studies
Year: 2009