Pulmonary hypertension in patients treated with Src/Abl kinase inhibitor dasatinib

D. Montani, E. Bergot, S. Günther, L. Savale, A. Bergeron, A. Bourdin, H. Bouvaist, M. Canuet, C. Pison, M. Macro, P. Poubeau, D. Natali, F. Perros, D. S. O‘Callaghan, X. Jaïs, G. Zalcman, O. Sitbon, G. Simonneau, M. Humbert (Clamart, Caen, Paris, Montpellier, Grenoble, Strasbourg, Saint-Pierre, Réunion, France)

Source: Annual Congress 2011 - Treatment of human pulmonary hypertension
Session: Treatment of human pulmonary hypertension
Session type: Thematic Poster Session
Number: 2294
Disease area: Pulmonary vascular diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
D. Montani, E. Bergot, S. Günther, L. Savale, A. Bergeron, A. Bourdin, H. Bouvaist, M. Canuet, C. Pison, M. Macro, P. Poubeau, D. Natali, F. Perros, D. S. O‘Callaghan, X. Jaïs, G. Zalcman, O. Sitbon, G. Simonneau, M. Humbert (Clamart, Caen, Paris, Montpellier, Grenoble, Strasbourg, Saint-Pierre, Réunion, France). Pulmonary hypertension in patients treated with Src/Abl kinase inhibitor dasatinib. Eur Respir J 2011; 38: Suppl. 55, 2294

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pulmonary complications of Bcr-Abl tyrosine kinase inhibitors
Source: Eur Respir J, 56 (4) 2000279; 10.1183/13993003.00279-2020
Year: 2020



Effectiveness of inhibitor mTOR in patients with lymphangioleiomyomatosis.
Source: International Congress 2018 – New insights in rare diffuse parenchymal lung diseases (DPLDs) in adults and children
Year: 2018




The selective Rho kinase inhibitor trans-6-((4-aminocyclohexyl)amino)-5-fluoro-2-methoxynicotinamide ameliorates experimental pulmonary hypertension
Source: International Congress 2017 – Experimental PH
Year: 2017

Mice deficient in Raf kinase inhibitor protein (RKIP) have elevated indices of pulmonary hypertension
Source: Annual Congress 2010 - Experimental pulmonary hypertension
Year: 2010

Pulmonary complications of tyrosine kinase inhibitors in myeloproliferative disorders
Source: Eur Respir J, 56 (4) 2002653; 10.1183/13993003.02653-2020
Year: 2020



Btk (Bruton’s tyrosine kinase) in B cells is overexpressed in patients with idiopathic pulmonary arterial hypertension
Source: International Congress 2015 – Pulmonary hypertension: novel insights into the biology of the disease
Year: 2015

Pharmacologic characterization of GB002, a novel inhaled PDGFR kinase inhibitor in development for pulmonary arterial hypertension (PAH)
Source: Virtual Congress 2020 – Pathophysiology of pulmonary hypertension
Year: 2020


Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance–pharmacodynamic study
Source: Eur Respir J, 53 (5) 1802472; 10.1183/13993003.02472-2018
Year: 2019



Rho kinase inhibitors for pulmonary hypertension: waiting for clinical evidence
Source: Eur Respir J 2010; 36: 709-711
Year: 2010


Prevention of pulmonary vascular and myocardial remodeling by the combined tyrosine and serine-/threonine kinase inhibitor, sorafenib, in pulmonary hypertension and right heart failure
Source: Annual Congress 2007 - Pathogenesis and novel therapeutic targets in pulmonary hypertension
Year: 2007


Prevention of pulmonary vascular and myocardial remodeling by the combined tyrosine and serine-/threonine kinase inhibitor, sorafenib, in pulmonary hypertension and right heart failure
Source: Eur Respir Rev 2008; 17: 72-73
Year: 2008



Effect of PDE-5 inhibitor treatment in patients with interstitial lung disease and pulmonary hypertension
Source: Annual Congress 2011 - Clinical perspectives in several interstitial diseases
Year: 2011

PDGF and Src tyrosine kinases in pulmonary arterial smooth muscle cells: Effects of dasatinib and nilotinib on pulmonary vascular remodeling
Source: Annual Congress 2011 - Treatments for pulmonary hypertension in human and experimental models
Year: 2011

The effect of mTOR inhibitors on respiratory infections in lymphangioleiomyomatosis
Source: Eur Respir Rev 2017; 26: 160004
Year: 2017



The inhibitory effect of PI3k inhibitor and MEK inhibitor on malignant pleural mesothelioma cell growth
Source: Annual Congress 2009 - Pleural and mediastinal diseases
Year: 2009


p38 MAPK inhibitors in COPD
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

The effects of oral p38 mitogen activated protein kinase (MAPK) inhibitor SB-681323 on blood biomarkers in COPD
Source: Annual Congress 2008 - Novel treatments for respiratory disease
Year: 2008


Pulmonary hypertension associated with ponatinib therapy
Source: Eur Respir J 2016; 47: 676-679
Year: 2016


Differential anti-inflammatory effects of budesonide and a p38 MAPK inhibitor AZD7624 on COPD pulmonary cells
Source: International Congress 2018 – Preclinical pharmacology: novel targets in airway inflammation, narrowing and neural control
Year: 2018