SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor growth and lung metastasis formation probably through the reduction of tumor angiogenesis

T. Masuda, N. Hattori, K. Hamai, S. Akita, T. Senoo, H. Iwamoto, S. Ohshimo, M. Kanehara, N. Ishikawa, K. Fujitaka, Y. Haruta, H. Murai, N. Kohno (Hiroshima, Japan)

Source: Annual Congress 2011 - Progress in pathology of lung cancer
Session: Progress in pathology of lung cancer
Session type: Poster Discussion
Number: 1479
Disease area: Thoracic oncology

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
T. Masuda, N. Hattori, K. Hamai, S. Akita, T. Senoo, H. Iwamoto, S. Ohshimo, M. Kanehara, N. Ishikawa, K. Fujitaka, Y. Haruta, H. Murai, N. Kohno (Hiroshima, Japan). SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor growth and lung metastasis formation probably through the reduction of tumor angiogenesis. Eur Respir J 2011; 38: Suppl. 55, 1479

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
The regulation of plasminogen activator inhibitor-1 (PAI-1) production with dexamethasone by human lung fibroblasts
Source: Eur Respir J 2005; 26: Suppl. 49, 343s
Year: 2005

Human lung microvascular endothelial cells (HMVEC-L) angiogenic activity is inhibited by stable plasminogen activator inhibitor-1 (PAI-1) mutants via urokinase-dependent pathway
Source: Annual Congress 2004 - Lung development and cancer
Year: 2004


Plasminogen activator inhibitor type 1 (PAI-1) is a negative regulator of lung cancer cells growth due to its anti-proteinase activity
Source: Annual Congress 2008 - Novel targets in the molecular pathology of lung cancer and COPD
Year: 2008


Plasminogen activator inhibitor-1 (PAI-1) mutations of extended half-life time inhibit angiogenic properties of human lung microvascular endothelial cells (HMVEC-L)
Source: Eur Respir J 2003; 22: Suppl. 45, 225s
Year: 2003

Proapoptotic and anti-proliferative effect of the stable plasminogen activator inhibitor type 1 (PAI-1) mutant on the lung cancer and endothelial cells
Source: Annual Congress 2009 - What is new in molecular pathology and functional genomics of neoplastic and non-neoplastic lung disease?
Year: 2009


Pro-urokinase up-regulates the expression of urokinase type plasminogen activator (u-PA) in human pulmonary arterial endothelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 143s
Year: 2007

The mechanism of plasminogen activator inhibitor type-1 (PAI-1) Cys mutants inhibitory activity towards lung capillaries endothelial cells (HMVEC-L)
Source: Eur Respir J 2005; 26: Suppl. 49, 93s
Year: 2005

Lung fibroblasts regulate the urokinase-type plasminogen activator receptor (uPAR) expression of alveolar epithelial cells and endothelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 397s
Year: 2006

The relation between plasminogen activator inhibitor-1 (PAI-1) and inflammatory markers in COPD: A possible risk factor of inflammation-induced thrombosis
Source: International Congress 2017 – Systemic and airway biomarkers
Year: 2017

Tumor-related angiogenesis: role in tumour growth and metastasis formation
Source: Annual Congress 2005 - Update on the role of angiogenesis in the pathogenesis and treatment of lung diseases
Year: 2005

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis
Source: Annual Congress 2010 - Experimental approaches in pulmonary fibrosis
Year: 2010

Influence of prostaglandin E2 on cell surface urokinase-type plasminogen activator expression and activity in lung adenocarcinoma cell line
Source: Eur Respir J 2005; 26: Suppl. 49, 457s
Year: 2005

Regulation of plasminogen activator activity by inflammatory mediators in lung epithelial cells
Source: Eur Respir J 2005; 26: Suppl. 49, 343s
Year: 2005

The effect of prostaglandin (PG) E2 and its receptor antagonists on urokinase-type plasminogen activator (uPA) production by human lung fibroblasts
Source: Eur Respir J 2006; 28: Suppl. 50, 811s
Year: 2006

Benzamidine-type urokinase inhibitors reduce primary tumor growth in a Lewis lung carcinoma model
Source: Eur Respir J 2005; 26: Suppl. 49, 92s
Year: 2005

Upregulation of the gene encoding the urokinase-type plasminogen activator (uPA) in respiratory muscles of COPD patients
Source: Annual Congress 2004 - Skeletal muscle in respiratory disease
Year: 2004


The biological effect of intrapleural tissue plasminogen (tPA) activator and DNase delivery in pleural infection patients.
Source: International Congress 2018 – New therapies for respiratory infections: experimental and translational studies
Year: 2018



Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 suppresses allergic asthma in a murine model
Source: Annual Congress 2010 - Animal models of asthma and lung inflammation
Year: 2010

Circulating fibrocytes depletion results in reduced lung tumor growth and metastasis by modulating macrophage phenotype, angiogenesis and endothelin system
Source: ERS Lung Science Conference 2017
Year: 2017

PP133 – IGF1R acts in the tumor microenvironment as a cancer-promoting factor facilitating the implantation and progression of lung metastasis
Source: ERS Lung Science Conference 2021
Year: 2021