Deadly networks: disease-causing protein and DNA modifications

Hot topics
Chairs: I. M. Adcock (London, United Kingdom), M. Cazzola (Rome, Italy)
Aims: At the conclusion of this session, the participant will be able to:
- describe the cutting-edge current concepts about how changes in histone and DNA structure regulate cell proliferation and gene expression at the ?epigenetic? level, and how these can apply to human pulmonary diseases;
- understand the importance of oxidative and nitrative stress in regulating signalling pathways and controlling cell function;
- appreciate the wealth of data implicating abnormal signalling in the control of epithelial cell function;
- understand the potential for the targeting of these processes in the development of novel drug treatments for diseases such as lung cancer, fibrosis, severe asthma and COPD.

Epigenetics and lung cancer M. Sanchez-Cespedes (Barcelona, Spain)
Clinical implications and opportunities for new drug therapies P. J. Barnes (London, United Kingdom)