February

The European Board of Accreditation in Pneumology (EBAP): reflections on 20 years promoting excellence in continuing medical education (CME) in respiratory medicine Georgia Hardavella, Mona Lichtblau, Alf Henrik Andreassen, Jamil Jubrail, Edin Jusufovic, Ortrud Karg, Laurent Nicod, Angelo Petroianni, Paolo Palange Eur Respir J, 61 (2) 2202231; 10.1183/13993003.02231-2022
Inhaled therapy, cardiovascular risk and benefit–risk considerations in COPD: innocent until proven guilty, or vice versa? Lucile Regard, Pierre-Régis Burgel, Nicolas Roche Eur Respir J, 61 (2) 2202135; 10.1183/13993003.02135-2022
Preventing bronchiolitis among infants with non-pharmaceutical interventions outside pandemics: is it realistic? Eva S.L. Pedersen, Claudia E. Kuehni Eur Respir J, 61 (2) 2202214; 10.1183/13993003.02214-2022
GM-CSF targeting in COVID-19: an approach based on fragile foundations Katharina Kohler, Andrew Conway Morris Eur Respir J, 61 (2) 2202091; 10.1183/13993003.02091-2022
Short- and long-term noninvasive cardiopulmonary exercise assessment in previously hospitalised COVID-19 patients Inderjit Singh, Phillip Joseph Eur Respir J, 61 (2) 2201739; 10.1183/13993003.01739-2022
Stage IV lung cancer: the relevance of tumour profile for the construction of prognostic groups Ramón Rami-Porta, Kwun M. Fong Eur Respir J, 61 (2) 2202094; 10.1183/13993003.02094-2022
Now we know: chronic exposure to air pollutants is a risk factor for the development of idiopathic pulmonary fibrosis Lucile Sesé, Sergio Harari Eur Respir J, 61 (2) 2202113; 10.1183/13993003.02113-2022
Nintedanib in chILD: a small step, yes… but at least a step forward in a marathon! David Gozal, Martin Kolb Eur Respir J, 61 (2) 2201797; 10.1183/13993003.01797-2022
Sympathetic activation in patients with heart failure and central sleep apnoea: is it friend or foe? Maria R. Bonsignore, Maria Teresa La Rovere Eur Respir J, 61 (2) 2202170; 10.1183/13993003.02170-2022
Cellular heterogeneity insights and molecular signatures in paediatric sleep apnoea Manuel Sánchez-de-la-Torre, Ferran Barbé Eur Respir J, 61 (2) 2202316; 10.1183/13993003.02316-2022
The gut microbiome in ARDS: from the “whether” and “what” to the “how” Kale S. Bongers, Kathleen A. Stringer, Robert P. Dickson Eur Respir J, 61 (2) 2202233; 10.1183/13993003.02233-2022
European Respiratory Society guideline on various aspects of quality in lung cancer care Torsten Gerriet Blum, Rebecca L. Morgan, Valérie Durieux, Joanna Chorostowska-Wynimko, David R. Baldwin, Jeanette Boyd, Corinne Faivre-Finn, Françoise Galateau-Salle, Fernando Gamarra, Bogdan Grigoriu, Georgia Hardavella, Michael Hauptmann, Erik Jakobsen, Dragana Jovanovic, Paul Knaut, Gilbert Massard, John McPhelim, Anne-Pascale Meert, Robert Milroy, Riccardo Muhr, Luciano Mutti, Marianne Paesmans, Pippa Powell, Paul Martin Putora, Janette Rawlinson, Anna L. Rich, David Rigau, Dirk de Ruysscher, Jean-Paul Sculier, Arnaud Schepereel, Dragan Subotic, Paul Van Schil, Thomy Tonia, Clare Williams, Thierry Berghmans Eur Respir J, 61 (2) 2103201; 10.1183/13993003.03201-2021
ERS/ESTS statement on the management of pleural infection in adults Eihab O. Bedawi, Sara Ricciardi, Maged Hassan, Michael R. Gooseman, Rachelle Asciak, Olalla Castro-Añón, Karin Armbruster, Martina Bonifazi, Sarah Poole, Elinor K. Harris, Stefano Elia, Rafal Krenke, Alessandro Mariani, Nick A. Maskell, Eva Polverino, Jose M. Porcel, Lonny Yarmus, Elizabeth P. Belcher, Isabelle Opitz, Najib M. Rahman Eur Respir J, 61 (2) 2201062; 10.1183/13993003.01062-2022
Genetic counselling and testing in pulmonary arterial hypertension: a consensus statement on behalf of the International Consortium for Genetic Studies in PAH Christina A. Eichstaedt, Catharina Belge, Wendy K. Chung, Stefan Gräf, Ekkehard Grünig, David Montani, Rozenn Quarck, Jair A. Tenorio-Castano, Florent Soubrier, Richard C. Trembath, Nicholas W. Morrell Eur Respir J, 61 (2) 2201471; 10.1183/13993003.01471-2022
Combination therapy with long-acting bronchodilators and the risk of major adverse cardiovascular events in patients with COPD: a systematic review and meta-analysis Mingjin Yang, Yishi Li, Youfan Jiang, Shuliang Guo, Jian-Qing He, Don D. Sin Eur Respir J, 61 (2) 2200302; 10.1183/13993003.00302-2022
Patient and physician factors associated with symptomatic undiagnosed asthma or COPD Mathew Cherian, Kate M.A. Magner, G.A. Whitmore, Katherine L. Vandemheen, J. Mark FitzGerald, Celine Bergeron, Louis-Philippe Boulet, Andreanne Cote, Stephen K. Field, Erika Penz, R. Andrew McIvor, Catherine Lemière, Samir Gupta, Irvin Mayers, Mohit Bhutani, Paul Hernandez, M. Diane Lougheed, Christopher J. Licskai, Tanweer Azher, Martha Ainslie, Nicole Ezer, Sunita Mulpuru, Shawn D. Aaron Eur Respir J, 61 (2) 2201721; 10.1183/13993003.01721-2022
Rhinitis phenotypes and multimorbidities in the general population: the CONSTANCES cohort Marine Savouré, Jean Bousquet, Bénédicte Leynaert, Adeline Renuy, Valérie Siroux, Marcel Goldberg, Marie Zins, Bénédicte Jacquemin, Rachel Nadif Eur Respir J, 61 (2) 2200943; 10.1183/13993003.00943-2022
Respective roles of non-pharmaceutical interventions in bronchiolitis outbreaks: an interrupted time-series analysis based on a multinational surveillance system Lea Lenglart, Naim Ouldali, Kate Honeyford, Zsolt Bognar, Silvia Bressan, Danilo Buonsenso, Liviana Da Dalt, Tisham De, Ruth Farrugia, Ian K. Maconochie, Henriette A. Moll, Rianne Oostenbrink, Niccolo Parri, Damian Roland, Katy Rose, Esra Akyüz Özkan, François Angoulvant, Camille Aupiais, Clarissa Barber, Michael Barrett, Romain Basmaci, Susana Castanhinha, Antonio Chiaretti, Sheena Durnin, Patrick Fitzpatrick, Laszlo Fodor, Borja Gomez, Susanne Greber-Platzer, Romain Guedj, Florian Hey, Lina Jankauskaite, Daniela Kohlfuerst, Ines Mascarenhas, Anna Maria Musolino, Zanda Pucuka, Sofia Reis, Alexis Rybak, Petra Salamon, Matthias Schaffert, Keren Shahar-Nissan, Maria Chiara Supino, Ozlem Teksam, Caner Turan, Roberto Velasco, Ruud G. Nijman, Luigi Titomanlio Eur Respir J, 61 (2) 2201172; 10.1183/13993003.01172-2022
In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes Rishi Chanderraj, Jennifer M. Baker, Stephen G. Kay, Christopher A. Brown, Kevin J. Hinkle, Daniel J. Fergle, Roderick A. McDonald, Nicole R. Falkowski, Joseph D. Metcalf, Keith S. Kaye, Robert J. Woods, Hallie C. Prescott, Michael W. Sjoding, Robert P. Dickson Eur Respir J, 61 (2) 2200910; 10.1183/13993003.00910-2022
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR) Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J. Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A. Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D. Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E. Schwab, Zainab Shahid, Michinori Shirano, Julia E. Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A. Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton Eur Respir J, 61 (2) 2101870; 10.1183/13993003.01870-2021
Changes in cardiopulmonary exercise capacity and limitations 3–12 months after COVID-19 Charlotte Björk Ingul, Anne Edvardsen, Turid Follestad, Divna Trebinjac, Odd Andre Wathne Ankerstjerne, Eivind Brønstad, Øystein Rasch-Halvorsen, Bernt Aarli, Håvard Dalen, Bjarne Martens Nes, Tøri Vigeland Lerum, Gunnar Einvik, Knut Stavem, Ingunn Skjørten Eur Respir J, 61 (2) 2200745; 10.1183/13993003.00745-2022
Prognostic factors in nonsmall cell lung cancer: insights from the German CRISP registry Martin Metzenmacher, Frank Griesinger, Horst-Dieter Hummel, Corinna Elender, Harald Schäfer, Maike de Wit, Ulrich Kaiser, Jens Kern, Martina Jänicke, Lisa Spring, Stefan Zacharias, Anja Kaiser-Osterhues, Annika Groth, Annette Hipper, Gregor Zaun, Steffen Dörfel, Björn Güldenzoph, Lothar Müller, Jens Uhlig, Michael Thomas, Martin Sebastian, Wilfried E.E. Eberhardt Eur Respir J, 61 (2) 2201336; 10.1183/13993003.01336-2022
Air pollutants, genetic susceptibility and risk of incident idiopathic pulmonary fibrosis Feipeng Cui, Yu Sun, Junqing Xie, Dankang Li, Mingyang Wu, Lulu Song, Yonghua Hu, Yaohua Tian Eur Respir J, 61 (2) 2200777; 10.1183/13993003.00777-2022
Nintedanib in children and adolescents with fibrosing interstitial lung diseases Robin Deterding, Lisa R. Young, Emily M. DeBoer, David Warburton, Steven Cunningham, Nicolaus Schwerk, Kevin R. Flaherty, Kevin K. Brown, Mihaela Dumistracel, Elvira Erhardt, Julia Bertulis, Martina Gahlemann, Susanne Stowasser, Matthias Griese Eur Respir J, 61 (2) 2201512; 10.1183/13993003.01512-2022
Deep-learning algorithm to detect fibrosing interstitial lung disease on chest radiographs Hirotaka Nishikiori, Koji Kuronuma, Kenichi Hirota, Naoya Yama, Tomohiro Suzuki, Maki Onodera, Koichi Onodera, Kimiyuki Ikeda, Yuki Mori, Yuichiro Asai, Yuzo Takagi, Seiwa Honda, Hirofumi Ohnishi, Masamitsu Hatakenaka, Hiroki Takahashi, Hirofumi Chiba Eur Respir J, 61 (2) 2102269; 10.1183/13993003.02269-2021
Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study Renaud Tamisier, Jean-Louis Pépin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cécile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Lévy Eur Respir J, 61 (2) 2200384; 10.1183/13993003.00384-2022
Single-cell RNA-seq uncovers cellular heterogeneity and provides a signature for paediatric sleep apnoea Rene Cortese, Taylor S. Adams, Kylie H. Cataldo, Justin Hummel, Naftali Kaminski, Leila Kheirandish-Gozal, David Gozal Eur Respir J, 61 (2) 2201465; 10.1183/13993003.01465-2022
Obstructive sleep apnoea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation Carolina Cubillos-Zapata, Miguel Ángel Martínez-García, Elena Díaz-García, Sara García-Tovar, Francisco Campos-Rodríguez, Manuel Sánchez-de-la-Torre, Eduardo Nagore, Antonio Martorell-Calatayud, Luis Hernández Blasco, Esther Pastor, Jorge Abad-Capa, Josep María Montserrat, Valentín Cabriada-Nuño, Irene Cano-Pumarega, Jaime Corral-Peñafiel, Eva Arias, Olga Mediano, María Somoza-González, Joan Dalmau-Arias, Isaac Almendros, Ramón Farré, David Gozal, Francisco García-Río Eur Respir J, 61 (2) 2200707; 10.1183/13993003.00707-2022
Gut microbiota-derived succinate aggravates acute lung injury after intestinal ischaemia/reperfusion in mice Yi-Heng Wang, Zheng-Zheng Yan, Si-Dan Luo, Jing-Juan Hu, Mei Wu, Jin Zhao, Wei-Feng Liu, Cai Li, Ke-Xuan Liu Eur Respir J, 61 (2) 2200840; 10.1183/13993003.00840-2022
Respiratory management of drowning-associated acute respiratory failure: a multicentre retrospective cohort study Florian Reizine, Yannick Fedun, Laetitia Bodenes, Pierre Bouju, Pierre Fillâtre, Aurélien Frérou, Olivier Lesieur, Arnaud Gacouin, Agathe Delbove Eur Respir J, 61 (2) 2201269; 10.1183/13993003.01269-2022
The impact of depression and anxiety on the risk of exacerbation in adults with bronchiectasis: a prospective cohort study Yong-Hua Gao, Hui-Zhen Zheng, Hai-Wen Lu, Yuan-Yuan Li, Yun Feng, Bei Mao, Jiu-Wu Bai, Shuo Liang, Ke-Bin Cheng, Shu-yi Gu, Xiao-Li Sun, Jian-Xiong Li, Ai Ge, Man-Hui Li, Jia-Wei Yang, Lu Bai, Han-Yu Yu, Jie-Ming Qu, Jin-Fu Xu Eur Respir J, 61 (2) 2201695; 10.1183/13993003.01695-2022
The puzzles of lung function interpretation Riccardo Pellegrino, Vito Brusasco Eur Respir J, 61 (2) 2202070; 10.1183/13993003.02070-2022
Reply: The puzzles of lung function interpretation Sanja Stanojevic, David A. Kaminsky, Martin Miller, Bruce Thompson Eur Respir J, 61 (2) 2202444; 10.1183/13993003.02444-2022
Comment on: Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery Maximilian Ackermann, Paul Tafforeau, Joseph Brunet, Jan C. Kamp, Christopher Werlein, Mark P. Kühnel, Joseph Jacob, Claire L. Walsh, Peter D. Lee, Tobias Welte, Danny D. Jonigk Eur Respir J, 61 (2) 2202121; 10.1183/13993003.02121-2022
Reply: Intrapulmonary shunt and alveolar dead space in a cohort of patients with acute COVID-19 pneumonitis and early recovery Piotr Harbut, G. Kim Prisk, Robert Lindwall, Sarah Hamzei, Jenny Palmgren, Catherine E. Farrow, Goran Hedenstierna, Terence C. Amis, Atul Malhotra, Peter D. Wagner, Kristina Kairaitis Eur Respir J, 61 (2) 2202287; 10.1183/13993003.02287-2022
Comment on: Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury Chang Liu, Kun Xiao, LiXin Xie Eur Respir J, 61 (2) 2200694; 10.1183/13993003.00694-2022
Reply: “Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury” Claudia C. dos Santos, Chirag M. Vaswani, Shirley H.J. Mei, Patricia R.M. Rocco, Daniel J. Weiss, Duncan J. Stewart, W. Conrad Liles Eur Respir J, 61 (2) 2200886; 10.1183/13993003.00886-2022
Insights into the clinical outcomes of bronchiectasis Zhen-feng He, Shan-shan Zha, Cui-xia Pan, Nan-shan Zhong, Wei-jie Guan Eur Respir J, 61 (2) 2202104; 10.1183/13993003.02104-2022
Reply to: Insights into the clinical outcomes of bronchiectasis Raja Dhar, James D. Chalmers Eur Respir J, 61 (2) 2202224; 10.1183/13993003.02224-2022
“Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages.” K. Hönzke, B. Obermayer, C. Mache, et al. Eur Respir J 2022; 60: 2102725 Eur Respir J, 61 (2) 2152725; 10.1183/13993003.52725-2021
“Spatial transcriptomics for respiratory research and medicine.” S. Curras-Alonso, J. Soulier, T. Walter, et al. Eur Respir J 2021; 58: 2004314 Eur Respir J, 61 (2) 2054314; 10.1183/13993003.54314-2020