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Advances in asthma pharmacology

Poster Discussion
Chairs: P. Bhavsar (London, United Kingdom), C. Page (London, United Kingdom)


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 [+]  Congress or journal article abstract 3868 Late Breaking Abstract - Sex differences in ß2 adrenoceptor-mediated responses in mouse airways
I. Cerqua (Naples, Italy), A. Rossi (Naples, Italy), M. Riemma (Naples, Italy), G. Cirino (Naples, Italy), F. Roviezzo (Naples, Italy)
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 [+]  Congress or journal article abstract 3870 Pharmacological characterization of the protective effect of benralizumab against airway hyperresponsiveness in a human ex vivo model of severe asthma
P. Rogliani (Rome, Italy), M. Matera (Naples, Italy), F. Cavalli (Rome, Italy), F. Facciolo (Rome, Italy), M. Cazzola (Rome, Italy), L. Calzetta (Rome, Italy)
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 [+]  Congress or journal article abstract E-poster 3871 Generation and activation of myeloid derived suppressor cells using prostaglandin E2 and EP receptor agonists in vitro
C. Van Geffen (Tübingen, Germany), S. Beer-Hammera (Tübingen, Germany), B. Nürnberg (Tübingen, Germany), S. Kolahian (Tübingen, Germany)
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 [+]  Congress or journal article abstract E-poster 3872 In vitro pharmacological characterization of the potent, lung selective pan-JAK inhibitor TD-8236
R. Sana (South San Francisco, United States of America), W. Krey-Epstein (South San Francisco, United States of America), E. Sandvik (South San Francisco, United States of America), E. Gordon (South San Francisco, United States of America), S. Calhoun (South San Francisco, United States of America), E. Kaufman (South San Francisco, United States of America), J. Budman (South San Francisco, United States of America), P. Fatheree (South San Francisco, United States of America), M. Kleinschek (South San Francisco, United States of America)
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 [+]  Congress or journal article abstract 3873 Mechanisms leading to the bronchorelaxant synergy of ICS/LABA/LAMA combination
L. Calzetta (Rome, Italy), M. Matera (Naples, Italy), J. Ora (Rome, Italy), F. Facciolo (Rome, Italy), M. Cazzola (Rome, Italy), P. Rogliani (Rome, Italy)
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 [+]  Congress or journal article abstract 3874 Pharmacological characterization of the protective effect of mepolizumab against airway hyperresponsiveness in a human ex vivo model of severe asthma
L. Calzetta (Rome, Italy), M. Matera (Naples, Italy), F. Cavalli (Rome, Italy), F. Facciolo (Rome, Italy), M. Cazzola (Rome, Italy), P. Rogliani (Rome, Italy)
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 [+]  Congress or journal article abstract 3875 Investigating Transient Receptor Potential V4 channel induced bronchospasm
P. Flajolet (London, United Kingdom), S. Bonvini (London, United Kingdom), B. Dekkak (London, United Kingdom), N. Kobold (London, United Kingdom), J. Adcock (Gothenburg, Sweden), P. Bradding (Leicester, United Kingdom), M. Belvisi (Gothenburg, Sweden), M. Birrell (Gothenburg, Sweden)
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 [+]  Congress or journal article abstract 3876 IL-33 blockade prevents exacerbations in a model of chronic airway inflammation by blunting persistent inflammation and remodeling
J. Allinne (Tarrytown, United States of America), W. Lim (Tarrytown, United States of America), G. Scott (Tarrytown, United States of America), C. Sandén (Lund, Sweden), J. Erjefält (Lund, Sweden), D. Birchard (Tarrytown, United States of America), L. Ben (Tarrytown, United States of America), A. Murphy (Tarrytown, United States of America), M. Sleeman (Tarrytown, United States of America), J. Orengo (Tarrytown, United States of America)
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 [+]  Congress or journal article abstract 3877 Broader Impact of IL-4Ra Blockade Than IL-5 Blockade on Type 2 Inflammation
J. Allinne (Tarrytown, United States of America), G. Scott (Tarrytown, United States of America), D. Birchard (Tarrytown, United States of America), S. Asrat (Tarrytown, United States of America), K. Nagashima (Tarrytown, United States of America), A. Le Floc'H (Tarrytown, United States of America), M. Sleeman (Tarrytown, United States of America), A. Murphy (Tarrytown, United States of America), G. Yancopoulos (Tarrytown, United States of America), J. Orengo (Tarrytown, United States of America)
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 [+]  Congress or journal article abstract E-poster 3878 The effect of endocannabinoid metabolism inhibition on airway inflammation in mice
R. Abohalaka (Ankara, Turkey), T. Bozkurt (Ankara, Turkey), E. Nemutlu (Ankara, Turkey), S. Onder (Ankara, Turkey), I. Sahin-Erdemli (Ankara, Turkey)
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 [+]  Congress or journal article abstract 3879 Intranasal treatment with the mitochondria-targeted slow hydrogen sulfide releasing donor AP39 prevents inflammation-induced airway hyperreactivity in mice
Y. Karaman-Kutluay (Ankara, Turkey), Y. Kaya-Yasar (Trabzon, Turkey), T. Bozkurt (Ankara, Turkey), S. Celik Onder (Ankara, Turkey), I. Sahin-Erdemli (Ankara, Turkey)
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 [+]  Congress or journal article abstract 3880 Relaxin potentiates ß2-adrenoceptor mediated bronchodilation in precision-cut lung slices (PCLS) from mouse models of airway inflammation and fibrosis, and in human airways
J. Bourke (Clayton, Australia), M. Lam (Clayton, Australia), C. Maksdi (Clayton, Australia), J. Chitty (Clayton, Australia), B. Thomas (Clayton, Australia), P. Bardin (Clayton, Australia), J. Jaffar (Prahran, Australia), G. Westall (Prahran, Australia), S. Royce (Clayton, Australia)
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 [+]  Congress or journal article abstract 3881 Bronchial thermoplasty induces cell type specific anti-airway remodeling via secreted HSP in vitro
L. Fang (Basel, Switzerland), M. Tamm (Basel, Switzerland), M. Roth (Basel, Switzerland), D. Stolz (Basel, Switzerland)
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 [+]  Congress or journal article abstract 3883 TLR7 Expression Reveals Novel Bronchodilating Mechanism of Imidazoquinoline Agonists
B. Proskocil (Portland, United States of America), A. Fryer (Portland, United States of America), D. Jacoby (Portland, United States of America), M. Drake (Portland, United States of America)
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 [+]  Congress or journal article abstract 3884 The calcium-sensing receptor CaSR mediates airway contraction in a house dust mite model of allergic airway disease
J. Bourke (Clayton, Australia), J. Diao (Parkville, Australia), M. Lam (Clayton, Australia), C. Maksdi (Clayton, Australia), K. Gregory (Parkville, Australia), K. Leach (Parkville, Australia)
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 [+]  Congress or journal article abstract 3885 The sensory irritant receptor TRPA1 is essential for airway inflammation in the LPS mouse model of acute lung injury.
A. Caceres (Durham, NC , United States of America), S. Jordt (Durham, NC , United States of America)
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