Human translational medicine: a key bridge for the development of new drugs for severe asthma, COPD and ILD; Dublin 2014

About
Research Seminars gather a small number (20 to 100) of well-established and preferably young investigators to address scientific topics in depth and help break new ground. Research Seminars take place over two days in easy-to-reach European cities. They are scientific Seminars involving recently published work and research in progress. Participation is fully supported by the budget granted by the ERS.
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Background
Despite remarkable progresses in the definition of cellular, biochemical and molecular biology pathways in the pathogenesis of Severe Asthma, Chronic Obstructive Pulmonary Disorder (COPD) and Interstitial Lung Disorders (ILDs), there is still a substantial unmet need for new drugs able to control and/or change the natural history of these diseases. This Seminar intended to underline the key role of a side-to-side collaboration between clinicians, scientists, bioinformaticians and statisticians in the comprehension of pathological processes underlying different respiratory disorders. It provided a framework to improve the ability to identify potential pharmacological targets for the development of innovative drugs.
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 [+]  Slide presentation Characterisation of clinical phenotypes is mandatory for the development of new drugs
N. Roche (Paris, France)
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 [+]  PDF journal article, handout or slides Slide presentation Asthma and COPD: similarities and differences in pathogenesis
A. Di Stefano (Veruno, Italy)
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 [+]  PDF journal article, handout or slides Slide presentation Bioinformatic tools for systems medicine in allergy
M. Benson (Linköping, Sweden)
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 [+]  PDF journal article, handout or slides Human translational medicine – phenotyping is key
R. Djukanovic (Southampton, United Kingdom)
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 [+]  Slide presentation Lipidomic phenotyping of severe asthma
J. Brandsma (Southampton, United Kingdom)
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 [+]  PDF journal article, handout or slides Slide presentation New drugs for severe asthma – what should we target and how?
K.F. Chung (London, United Kingdom)
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 [+]  PDF journal article, handout or slides Slide presentation Translational research approaches for finding new therapeutic targets involved in viral-induced asthma and COPD exacerbation
L. Uller (Lund, Sweden)
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 [+]  Slide presentation Developing integrated handprints of severe asthma: the U-BIOPRED approach
B. De Meulder (Lyon, France)
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 [+]  PDF journal article, handout or slides Human translational medicine in ILD: the promise of new drugs
O. Eickelberg (Munich, Germany)
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10 Multivariate analysis in a megavariate world: applications of multivariate modeling to biomarker identification in pulmonary medicine
C. Wheelock (Stockholm, Sweden)
 [+]  PDF journal article, handout or slides Slide presentation 11 New Drugs for COPD: the current status
I. Adcock (London, United Kingdom)
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 [+]  PDF journal article, handout or slides Slide presentation 12 COPD – will new insights into molecular pathology define new therapies?
C. Greene (Dublin, Ireland)
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 [+]  PDF journal article, handout or slides PDF journal article, handout or slides 13 What are the knowledge gaps in COPD that prevent new drug development?
G. Caramori (Ferrara, Italy)
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 [+]  Slide presentation 14 Chaperonins in COPD
F. Cappello (Palermo, Italy)
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