Abstract
Our purpose was to research central arterial pressure (CAP), its interrelations with peripheral arterial pressure (PAP) and aortic stiffness parameters in asthma patients. We examined 45 asthma patients and 25 healthy volunteers by noninvasive arteriography (arteriograph TensioClinic TL1 (TensioMed, Hungary)). Aortic stiffness and aortic systolic arterial pressure (SAP) were definite. Difference between central and peripheral SAP (ΔSAP); index of conformity CAP to PAP (IC) were estimated.
According to the indirect arteriography the central (aortic) SAP is increased to 20-40 % from norm in the majority of patients with exacerbation of severe (SAP=136,2±7,6 mm hg; p<0,05) and medium asthma (SAP=156,6±10,9 mm hg; p<0,05). During asthma exacerbation ΔSAP is sharply reduced and IC is increased (ΔSAP=-3,8±2,7; p<0,05) in comparison with healthy persons at whom ΔSAP makes -10,2±2,1 mm hg. It specifies disproportion of central and peripheral arterial pressure ratio at asthma exacerbation. During asthma remission CAP, PAP, ΔSAP and IC do not differ from control values that testify transitory character of haemodynamic infringements during asthma exacerbation. Expressiveness of aortic SAP increase during asthma exacerbation is closely connected with infringement of arterial mechanical properties. Statistically significant correlations between parameters of aortic SAP and hypoxemia (r=-0,84; p<0,05), system inflammation (r=0,86; p<0,05), oxidative stress (r=0,49; p<0,05) and hyponitrooxidemia (r=-0,48; p<0,05) levels were revealed. Those data can testify the important role of the listed factors in the pathogenesis of aortic SAP increases in asthma patients.