European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

June

Time for precision medicine in systemic sclerosis-associated pulmonary arterial hypertension David Launay, Sébastien Sanges, Vincent Sobanski Eur Respir J, 57 (6) 2100205; 10.1183/13993003.00205-2021
Ambulatory management of secondary spontaneous pneumothorax: a mirage, or a solution on the horizon? Srinivas R. Mummadi, José M. Porcel Eur Respir J, 57 (6) 2100003; 10.1183/13993003.00003-2021
Methylxanthines in COPD: yes to caffeine, no to theophylline Ken M. Kunisaki, Don D. Sin Eur Respir J, 57 (6) 2004564; 10.1183/13993003.04564-2020
The coming-of-age of bedaquiline: a tale with an open ending Lorenzo Guglielmetti, Francis Varaine Eur Respir J, 57 (6) 2100066; 10.1183/13993003.00066-2021
Shifting the paradigm: unilateral infiltrates and ARDS? Antoni Torres, Enric Barbeta, Tobias Welte Eur Respir J, 57 (6) 2100043; 10.1183/13993003.00043-2021
Improving adherence to asthma medications: same-old, same-old? Mark Weatherall Eur Respir J, 57 (6) 2004284; 10.1183/13993003.04284-2020
Evidence of air pollution exposure and new asthma onset: further justification for cleaner air George D. Thurston, Alison Lee Eur Respir J, 57 (6) 2100064; 10.1183/13993003.00064-2021
ERS statement on chronic thromboembolic pulmonary hypertension Marion Delcroix, Adam Torbicki, Deepa Gopalan, Olivier Sitbon, Frederikus A. Klok, Irene Lang, David Jenkins, Nick H. Kim, Marc Humbert, Xavier Jais, Anton Vonk Noordegraaf, Joanna Pepke-Zaba, Philippe Brénot, Peter Dorfmuller, Elie Fadel, Hossein-Ardeschir Ghofrani, Marius M. Hoeper, Pavel Jansa, Michael Madani, Hiromi Matsubara, Takeshi Ogo, Ekkehard Grünig, Andrea D'Armini, Nazzareno Galie, Bernhard Meyer, Patrick Corkery, Gergely Meszaros, Eckhard Mayer, Gérald Simonneau Eur Respir J, 57 (6) 2002828; 10.1183/13993003.02828-2020
World Health Organization recommendations on the treatment of drug-resistant tuberculosis, 2020 update Fuad Mirzayev, Kerri Viney, Nguyen Nhat Linh, Licé Gonzalez-Angulo, Medea Gegia, Ernesto Jaramillo, Matteo Zignol, Tereza Kasaeva Eur Respir J, 57 (6) 2003300; 10.1183/13993003.03300-2020
Identifying early pulmonary arterial hypertension biomarkers in systemic sclerosis: machine learning on proteomics from the DETECT cohort Yasmina Bauer, Simon de Bernard, Peter Hickey, Karri Ballard, Jeremy Cruz, Peter Cornelisse, Harbajan Chadha-Boreham, Oliver Distler, Daniel Rosenberg, Martin Doelberg, Sebastien Roux, Oliver Nayler, Allan Lawrie Eur Respir J, 57 (6) 2002591; 10.1183/13993003.02591-2020
Ambulatory management of secondary spontaneous pneumothorax: a randomised controlled trial Steven P. Walker, Emma Keenan, Oliver Bintcliffe, Andrew E. Stanton, Mark Roberts, Justin Pepperell, Ian Fairbairn, Edward McKeown, James Goldring, Nadeem Maddekar, James Walters, Alex West, Amrithraj Bhatta, Matthew Knight, Rachel Mercer, Rob Hallifax, Paul White, Robert F. Miller, Najib M. Rahman, Nick A. Maskell Eur Respir J, 57 (6) 2003375; 10.1183/13993003.03375-2020
Epidemiology of pleural empyema in English hospitals and the impact of influenza David T. Arnold, Fergus W. Hamilton, Tim T. Morris, Tim Suri, Anna Morley, Vicky Frost, Ian B. Vipond, Andrew R. Medford, Rupert A. Payne, Peter Muir, Nick A. Maskell Eur Respir J, 57 (6) 2003546; 10.1183/13993003.03546-2020
The effect of low-dose corticosteroids and theophylline on the risk of acute exacerbations of COPD: the TASCS randomised controlled trial Christine R. Jenkins, Fu-Qiang Wen, Allison Martin, Peter J. Barnes, Bartolome Celli, Nan-Shan Zhong, Jin-Ping Zheng, Anish Scaria, Gian-Luca Di Tanna, Thomas Bradbury, Norbert Berend Eur Respir J, 57 (6) 2003338; 10.1183/13993003.03338-2020
Impact of bedaquiline on treatment outcomes of multidrug-resistant tuberculosis in a high-burden country Dumitru Chesov, Jan Heyckendorf, Sofia Alexandru, Ana Donica, Elena Chesov, Maja Reimann, Valeriu Crudu, Victor Botnaru, Christoph Lange Eur Respir J, 57 (6) 2002544; 10.1183/13993003.02544-2020
Viable virus aerosol propagation by positive airway pressure circuit leak and mitigation with a ventilated patient hood Shane A. Landry, Jeremy J. Barr, Martin I. MacDonald, Dinesh Subedi, Darren Mansfield, Garun S. Hamilton, Bradley A. Edwards, Simon A. Joosten Eur Respir J, 57 (6) 2003666; 10.1183/13993003.03666-2020
Outcome of acute hypoxaemic respiratory failure: insights from the LUNG SAFE Study Tài Pham, Antonio Pesenti, Giacomo Bellani, Gordon Rubenfeld, Eddy Fan, Guillermo Bugedo, José Angel Lorente, Antero do Vale Fernandes, Frank Van Haren, Alejandro Bruhn, Fernando Rios, Andres Esteban, Luciano Gattinoni, Anders Larsson, Daniel F. McAuley, Marco Ranieri, B. Taylor Thompson, Hermann Wrigge, Laurent J. Brochard, John G. Laffey Eur Respir J, 57 (6) 2003317; 10.1183/13993003.03317-2020
The benefits of a systematic assessment of respiratory health in illness-susceptible athletes James H. Hull, Anna R. Jackson, Craig Ranson, Freddie Brown, Moses Wootten, Mike Loosemore Eur Respir J, 57 (6) 2003722; 10.1183/13993003.03722-2020
A randomised controlled trial of the effect of a connected inhaler system on medication adherence in uncontrolled asthmatic patients Alison Moore, Andrew Preece, Raj Sharma, Liam G. Heaney, Richard W. Costello, Robert A. Wise, Andrea Ludwig-Sengpiel, Giselle Mosnaim, Jamie Rees, Ryan Tomlinson, Ruth Tal-Singer, David A. Stempel, Neil Barnes Eur Respir J, 57 (6) 2003103; 10.1183/13993003.03103-2020
Prevalence, progression and impact of chronic cough on employment in Northern Europe Henrik Johansson, Ane Johannessen, Mathias Holm, Bertil Forsberg, Vivi Schlünssen, Rain Jõgi, Michael Clausen, Eva Lindberg, Andrei Malinovschi, Össur Ingi Emilsson Eur Respir J, 57 (6) 2003344; 10.1183/13993003.03344-2020
Machine learning can predict disease manifestations and outcomes in lymphangioleiomyomatosis Saisakul Chernbumroong, Janice Johnson, Nishant Gupta, Suzanne Miller, Francis X. McCormack, Jonathan M. Garibaldi, Simon R. Johnson Eur Respir J, 57 (6) 2003036; 10.1183/13993003.03036-2020
Functional respiratory imaging provides novel insights into the long-term respiratory sequelae of bronchopulmonary dysplasia Kristien Vanhaverbeke, Monique Slaats, Mohammed Al-Nejar, Niek Everaars, Annemiek Snoeckx, Maarten Spinhoven, Haroun El Addouli, Eline Lauwers, Annelies Van Eyck, Benedicte Y. De Winter, Kim Van Hoorenbeeck, Jozef De Dooy, Ludo Mahieu, Benjamin Mignot, Jan De Backer, Antonius Mulder, Stijn Verhulst Eur Respir J, 57 (6) 2002110; 10.1183/13993003.02110-2020
Rescue of multiple class II CFTR mutations by elexacaftor+tezacaftor+ivacaftor mediated in part by the dual activities of elexacaftor as both corrector and potentiator Onofrio Laselva, Claire Bartlett, Tarini N.A. Gunawardena, Hong Ouyang, Paul D.W. Eckford, Theo J. Moraes, Christine E. Bear, Tanja Gonska Eur Respir J, 57 (6) 2002774; 10.1183/13993003.02774-2020
IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease Matthias Hagner, Melanie Albrecht, Matteo Guerra, Peter Braubach, Olga Halle, Zhe Zhou-Suckow, Simone Butz, Danny Jonigk, Gesine Hansen, Carsten Schultz, Anna-Maria Dittrich, Marcus A. Mall Eur Respir J, 57 (6) 1900716; 10.1183/13993003.00716-2019
TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection Leonardo Duarte Santos, Krist Helen Antunes, Stéfanie Primon Muraro, Gabriela Fabiano de Souza, Amanda Gonzalez da Silva, Jaqueline de Souza Felipe, Larissa Cardoso Zanetti, Rafael Sanguinetti Czepielewski, Karen Magnus, Marcelo Scotta, Rita Mattiello, Fabio Maito, Ana Paula Duarte de Souza, Ricardo Weinlich, Marco Aurélio Ramirez Vinolo, Bárbara Nery Porto Eur Respir J, 57 (6) 2003764; 10.1183/13993003.03764-2020
Epigenetics and pulmonary diseases in the horizon of precision medicine: a review Giuditta Benincasa, Dawn L. DeMeo, Kimberly Glass, Edwin K. Silverman, Claudio Napoli Eur Respir J, 57 (6) 2003406; 10.1183/13993003.03406-2020
Targeting cystic fibrosis inflammation in the age of CFTR modulators: focus on macrophages Jonathan L. Gillan, Donald J. Davidson, Robert D. Gray Eur Respir J, 57 (6) 2003502; 10.1183/13993003.03502-2020
A case series on the use of steroids and mycophenolate mofetil in idiopathic and heritable pulmonary veno-occlusive disease: is there a role for immunosuppression? Carmel Bergbaum, Chinthaka B. Samaranayake, Alex Pitcher, Emma Weingart, Thomas Semple, Maria Kokosi, Athol U. Wells, David Montani, Konstantinos Dimopoulos, Colm McCabe, Aleksander Kempny, Carl Harries, Elizabeth Orchard, S. John Wort, Laura C. Price Eur Respir J, 57 (6) 2004354; 10.1183/13993003.04354-2020
The high mental health burden of “Long COVID” and its association with on-going physical and respiratory symptoms in all adults discharged from hospital Sindhu B. Naidu, Amar J. Shah, Anita Saigal, Colette Smith, Simon E. Brill, James Goldring, John R. Hurst, Hannah Jarvis, Marc Lipman, Swapna Mandal Eur Respir J, 57 (6) 2004364; 10.1183/13993003.04364-2020
Screening for tuberculosis among high-risk groups attending London emergency departments: a prospective observational study Rishi K. Gupta, Swaib A. Lule, Maria Krutikov, Lara Gosce, Nathan Green, Jo Southern, Ambreen Imran, Robert W. Aldridge, Heinke Kunst, Marc Lipman, William Lynn, Helen Burgess, Asif Rahman, Dee Menezes, Ananna Rahman, Simon Tiberi, Peter J. White, Ibrahim Abubakar Eur Respir J, 57 (6) 2003831; 10.1183/13993003.03831-2020
Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases Shu-Yi Liao, Shaikh M. Atif, Kara Mould, Iain R. Konigsberg, Rui Fu, Elizabeth Davidson, Li Li, Andrew P. Fontenot, Lisa A. Maier, Ivana V. Yang Eur Respir J, 57 (6) 2003794; 10.1183/13993003.03794-2020
The Severe Asthma Questionnaire: sensitivity to change and minimal clinically important difference Matthew Masoli, Joseph W. Lanario, Michael E. Hyland, Andrew Menzies-Gow, Adel H. Mansur, David Allen, James W. Dodd, Gemma Hayes, Jose M. Valderas, Sarah E. Lamb, Rupert C. Jones Eur Respir J, 57 (6) 2100300; 10.1183/13993003.00300-2021
Methacholine reactivity in lymphangioleiomyomatosis is inversely related to FEV₁ and VEGF-D Roberto Cassandro, Davide Elia, Antonella Caminati, Gustavo Pacheco-Rodriguez, Mario Stylianou, Joel Moss, Sergio Harari Eur Respir J, 57 (6) 2004270; 10.1183/13993003.04270-2020
Real world effectiveness of anti-IL-5/5R therapies is independent of co-eligibility for anti-IgE therapy Andrew P. Hearn, Oliver D. Hug, Ziana A. Somani, Joanne Kavanagh, Grainne d'Ancona, Cris Roxas, Linda Green, Louise Thomson, Mariana Fernandes, Brian D. Kent, Jaideep Dhariwal, Alexandra M. Nanzer, David J. Jackson Eur Respir J, 57 (6) 2100166; 10.1183/13993003.00166-2021
Effect of corrected Global Lung Function Initiative reference equations on carbon monoxide transfer factor interpretation Warren R. Ruehland, Celia J. Lanteri, Pam Matsas, Danny J. Brazzale Eur Respir J, 57 (6) 2004459; 10.1183/13993003.04459-2020
Fine particulate matter and out-of-hospital cardiac arrest of respiratory origin Sunao Kojima, Takehiro Michikawa, Kunihiko Matsui, Hisao Ogawa, Shin Yamazaki, Hiroshi Nitta, Akinori Takami, Kayo Ueda, Yoshio Tahara, Naohiro Yonemoto, Hiroshi Nonogi, Ken Nagao, Takanori Ikeda, Yoshio Kobayashi Eur Respir J, 57 (6) 2004299; 10.1183/13993003.04299-2020
The role of cardiopulmonary exercise test in identifying pulmonary veno-occlusive disease Carmen Pérez-Olivares, Teresa Segura de la Cal, Ángela Flox-Camacho, Jorge Nuche, Jair Tenorio, Amaya Martínez Meñaca, Alejandro Cruz-Utrilla, Javier de la Cruz-Bertolo, Marte Pérez Núñez, Spanish PAH Consortium, Fernando Arribas-Ynsaurriaga, Pilar Escribano Subías Eur Respir J, 57 (6) 2100115; 10.1183/13993003.00115-2021
The association between inhaled corticosteroid and osteoporosis and fracture Cheng-Yi Wang, Chih-Cheng Lai Eur Respir J, 57 (6) 2100216; 10.1183/13993003.00216-2021
Pulse oximetry is an essential tool that saves lives: a call for standardisation Catia Cilloniz, Anita Simonds, Kjeld Hansen, Josep Alouch, Heather Zar, Yoichi Nakanishi, Stephanie Levine, Mark Cohen, Charles Dela Cruz, Scott E. Evans, Maurizio Sanguinetti, Jordi Vila, Jesús Díez Manglano, Ricard Ferrer, Lucio Criado, José Polo García, Zaira Correcher, Diana Rodriguez-Hurtado, Carmen Terrazas, Carmen Muñoz-Almagro, Carolina Garcia-Vidal, Zeina Aoun, Israel Amirav Eur Respir J, 57 (6) 2100815; 10.1183/13993003.00815-2021