European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

October

Editorials

Doubts about the adverse effects of air pollution on asthma? Isabella Annesi-Maesano, Francesco Forastiere Eur Respir J, 54 (4) 1901900; 10.1183/13993003.01900-2019
Identifying the at risk smokers: who goes on to get COPD? Arina Madan, Alice M. Turner Eur Respir J, 54 (4) 1901613; 10.1183/13993003.01613-2019
Screening migrants for tuberculosis and latent TB infection: the reward will come later Jean-Pierre Zellweger Eur Respir J, 54 (4) 1901719; 10.1183/13993003.01719-2019
Why are people with asthma more susceptible to influenza? Peter A.B. Wark Eur Respir J, 54 (4) 1901748; 10.1183/13993003.01748-2019
The future of drug-resistant tuberculosis treatment: learning from the past and the 2019 World Health Organization consolidated guidelines José A. Caminero, Alberto L. García-Basteiro, Adrián Rendon, Alberto Piubello, Emanuele Pontali, Giovanni Battista Migliori Eur Respir J, 54 (4) 1901272; 10.1183/13993003.01272-2019
Is gender inequity in ventilator management a “women's issue”? Marcus J. Schultz, Christian Karagiannidis Eur Respir J, 54 (4) 1901588; 10.1183/13993003.01588-2019
Is adding fluoroquinolones to regimens for treating isoniazid-resistant tuberculosis necessary? Roland Diel, Neil W. Schluger Eur Respir J, 54 (4) 1901494; 10.1183/13993003.01494-2019
Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD Mathew Suji Eapen, Pawan Sharma, Sukhwinder Singh Sohal Eur Respir J, 54 (4) 1901641; 10.1183/13993003.01641-2019
Looking backwards: is it time to assess veno-atrial interactions in pulmonary arterial hypertension? Steven Pugliese, Rebecca R. Vanderpool Eur Respir J, 54 (4) 1901598; 10.1183/13993003.01598-2019
Translation of in vitro findings to patients with asthma: a timely and compelling challenge Pieter S. Hiemstra, Peter J. Sterk Eur Respir J, 54 (4) 1901759; 10.1183/13993003.01759-2019

Asthma and epidemiology

Outdoor air pollution and the burden of childhood asthma across Europe Haneen Khreis, Marta Cirach, Natalie Mueller, Kees de Hoogh, Gerard Hoek, Mark J. Nieuwenhuijsen, David Rojas-Rueda Eur Respir J, 54 (4) 1802194; 10.1183/13993003.02194-2018

Asthma and genetics

The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D Rachel S. Kelly, Bo L. Chawes, Feng Guo, Li Zhang, Kevin Blighe, Augusto A. Litonjua, Benjamin A. Raby, Bruce D. Levy, Daniela Rago, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Xiaobo Zhou, Jessica A. Lasky-Su, Scott T. Weiss Eur Respir J, 54 (4) 1900761; 10.1183/13993003.00761-2019

Interstitial lung disease

Epidemiology and health outcomes of sarcoidosis in a universal healthcare population: a cohort study Lee M. Fidler, Meyer Balter, Jolene H. Fisher, Teresa To, Matthew B. Stanbrook, Andrea Gershon Eur Respir J, 54 (4) 1900444; 10.1183/13993003.00444-2019

Asthma

Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza Akhilesh Jha, Jake Dunning, Tanushree Tunstall, Ryan S. Thwaites, Long T. Hoang, Onn Min Kon, Maria C. Zambon, Trevor T. Hansel, Peter J. Openshaw Eur Respir J, 54 (4) 1900949; 10.1183/13993003.00949-2019

Acute lung injury and critical care

Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study Bairbre A. McNicholas, Fabiana Madotto, Tài Pham, Emanuele Rezoagli, Claire H. Masterson, Shahd Horie, Giacomo Bellani, Laurent Brochard, John G. Laffey Eur Respir J, 54 (4) 1900609; 10.1183/13993003.00609-2019
Increase in circulating ACE-positive endothelial microparticles during acute lung injury Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Hisatoshi Sugiura, Tomonori Makiguchi, Naoya Fujino, Akira Koarai, Hiroaki Toyama, Kazutomo Saito, Yutaka Ejima, Yu Kawazoe, Daisuke Kudo, Shigeki Kushimoto, Masanori Yamauchi, Masakazu Ichinose Eur Respir J, 54 (4) 1801188; 10.1183/13993003.01188-2018

Lung structure and function

Age at menopause and lung function: a Mendelian randomisation study Diana A. van der Plaat, Miguel Pereira, Giancarlo Pesce, James F. Potts, André F.S. Amaral, Shyamali C. Dharmage, Judith M. Garcia-Aymerich, John R. Thompson, Francisco Gómez Real, Deborah L. Jarvis, Cosetta Minelli, Bénédicte Leynaert Eur Respir J, 54 (4) 1802421; 10.1183/13993003.02421-2018

Lung cancer

Sequential screening for lung cancer in a high-risk group: randomised controlled trial Stephen G. Spiro, Pallav L. Shah, Robert C. Rintoul, Jeremy George, Samuel Janes, Matthew Callister, Marco Novelli, Penny Shaw, Gabrijela Kocjan, Chris Griffiths, Mary Falzon, Richard Booton, Nicholas Magee, Michael Peake, Paul Dhillon, Kishore Sridharan, Andrew G. Nicholson, Simon Padley, Magali N. Taylor, Asia Ahmed, Jack Allen, Yenting Ngai, Nyasha Chinyanganya, Victoria Ashford-Turner, Sarah Lewis, Dahmane Oukrif, Pamela Rabbitts, Nicholas Counsell, Allan Hackshaw Eur Respir J, 54 (4) 1900581; 10.1183/13993003.00581-2019

Tuberculosis

Tuberculosis among asylum seekers in Milan, Italy: epidemiological analysis and evaluation of interventions Simone Villa, Luigi Ruffo Codecasa, Marino Faccini, Mirella Maria Pontello, Maurizio Ferrarese, Paola Francesca Castellotti, Sabrina Senatore, Anna Lamberti, Ester Mazzola, Carlo Federico Perno, Daniela Campisi, Matteo Saporiti, Mario Carlo Raviglione Eur Respir J, 54 (4) 1900896; 10.1183/13993003.00896-2019
Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance Helen R. Stagg, Graham H. Bothamley, Jennifer A. Davidson, Heinke Kunst, Maeve K. Lalor, Marc C. Lipman, Miranda G. Loutet, Stefan Lozewicz, Tehreem Mohiyuddin, Aula Abbara, Eliza Alexander, Helen Booth, Dean D. Creer, Ross J. Harris, Onn Min Kon, Michael R. Loebinger, Timothy D. McHugh, Heather J. Milburn, Paramita Palchaudhuri, Patrick P.J. Phillips, Erik Schmok, Lucy Taylor, Ibrahim Abubakar Eur Respir J, 54 (4) 1900982; 10.1183/13993003.00982-2019

COPD

Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS Mehrdad Arjomandi, Siyang Zeng, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Russell G. Buhr, Gerard J. Criner, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Jeffrey L. Curtis, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Richard E. Kanner, Jerry A. Krishnan, Robert Paine, Stephen P. Peters, Stephen I. Rennard, Prescott G. Woodruff Eur Respir J, 54 (4) 1802214; 10.1183/13993003.02214-2018
Time-course of upper respiratory tract viral infection and COPD exacerbation Daiana Stolz, Eleni Papakonstantinou, Leticia Grize, Daniel Schilter, Werner Strobel, Renaud Louis, Christian Schindler, Hans H. Hirsch, Michael Tamm Eur Respir J, 54 (4) 1900407; 10.1183/13993003.00407-2019

COPD and basic science

Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages Kylie B.R. Belchamber, Richa Singh, Craig M. Batista, Moira K. Whyte, David H. Dockrell, Iain Kilty, Matthew J. Robinson, Jadwiga A. Wedzicha, Peter J. Barnes, Louise E. Donnelly Eur Respir J, 54 (4) 1802244; 10.1183/13993003.02244-2018

Pulmonary hypertension

Vena cava backflow and right ventricular stiffness in pulmonary arterial hypertension J. Tim Marcus, Berend E. Westerhof, Joanne A. Groeneveldt, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf Eur Respir J, 54 (4) 1900625; 10.1183/13993003.00625-2019
Efficacy and safety of ralinepag, a novel oral IP agonist, in PAH patients on mono or dual background therapy: results from a phase 2 randomised, parallel group, placebo-controlled trial Fernando Torres, Harrison Farber, Arsen Ristic, Vallerie McLaughlin, John Adams, Jinkun Zhang, Preston Klassen, William Shanahan, John Grundy, Ines Hoffmann, Christopher Cabell, Pilar Escribano Subías, Namita Sood, Anne Keogh, Gwyn D'Souza, Lewis Rubin Eur Respir J, 54 (4) 1901030; 10.1183/13993003.01030-2019

Pulmonary hypertension and basic science

CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension Shariq Abid, Elisabeth Marcos, Aurélien Parpaleix, Valérie Amsellem, Marielle Breau, Amal Houssaini, Nora Vienney, Marine Lefevre, Genevieve Derumeaux, Steven Evans, Cedric Hubeau, Marion Delcroix, Rozenn Quarck, Serge Adnot, Larissa Lipskaia Eur Respir J, 54 (4) 1802308; 10.1183/13993003.02308-2018

Perspective

In vivo observations provide insight into roles of eosinophils and epithelial cells in asthma Carl Persson Eur Respir J, 54 (4) 1900470; 10.1183/13993003.00470-2019

Review

The emerging role of mast cell proteases in asthma Gunnar Pejler Eur Respir J, 54 (4) 1900685; 10.1183/13993003.00685-2019

Research letters

Pectus excavatum is associated with sleep-related breathing disorders in children Hiroo Wada, Manami Kimura, Ryutaro Shirahama, Ai Ikeda, David Gozal, Takeshi Tanigawa Eur Respir J, 54 (4) 1900524; 10.1183/13993003.00524-2019
Epstein–Barr virus in pleural effusions: protagonist or pretender? David T. Arnold, Tim Suri, Fergus Hamilton, Anna Morley, Andrew Medford, Ian B. Vipond, Peter Muir, Nick A. Maskell Eur Respir J, 54 (4) 1900825; 10.1183/13993003.00825-2019
Prevalence of pulmonary hypertension in pulmonary sarcoidosis: the first large European prospective study Marloes P. Huitema, Annelies L.M. Bakker, Johannes J. Mager, Benno J.W.M. Rensing, Fokko Smits, Repke J. Snijder, Jan C. Grutters, Marco C. Post Eur Respir J, 54 (4) 1900897; 10.1183/13993003.00897-2019
Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality Jasleen Pannu, Lance J. Roller, Fabien Maldonado, Robert J. Lentz, Heidi Chen, Otis B. Rickman Eur Respir J, 54 (4) 1900337; 10.1183/13993003.00337-2019
Blood eosinophil counts in COPD patients compared to controls Umme Kolsum, Thomas Southworth, Natalie Jackson, Dave Singh Eur Respir J, 54 (4) 1900633; 10.1183/13993003.00633-2019
Time trends in diagnostic testing for primary ciliary dyskinesia in Europe Florian S. Halbeisen, Amelia Shoemark, Angelo Barbato, Mieke Boon, Siobhan Carr, Suzanne Crowley, Rob Hirst, Bulent Karadag, Cordula Koerner-Rettberg, Michael R. Loebinger, Jane S. Lucas, Bernard Maitre, Henryk Mazurek, Ugur Özçelik, Vendula Martinu, Nicolaus Schwerk, Guillaume Thouvenin, Stefan A. Tschanz, Panayiotis Yiallouros, Myrofora Goutaki, Claudia E. Kuehni Eur Respir J, 54 (4) 1900528; 10.1183/13993003.00528-2019
Circadian rhythm of exhaled biomarkers in health and asthma Maxim Wilkinson, Robert Maidstone, Andrew Loudon, John Blaikley, Iain R. White, Dave Singh, David W. Ray, Royston Goodacre, Stephen J. Fowler, Hannah J. Durrington Eur Respir J, 54 (4) 1901068; 10.1183/13993003.01068-2019
Tuberculosis following renal transplantation in England, Wales and Northern Ireland: a national registry-based cohort study Rishi K. Gupta, Gabriel Rosenberg, Jaran Eriksen, Marc Lipman, Charlotte Jackson, Anjana Roy, Dominik Zenner, Colette Smith, Mark Harber, Colin Campbell, Ibrahim Abubakar Eur Respir J, 54 (4) 1802245; 10.1183/13993003.02245-2018
Profiles of tuberculosis disease activation among contacts of patients with tuberculosis Yayehirad A. Melsew, Allen C. Cheng, Emma S. McBryde, Justin T. Denholm, EeLaine Tay, Romain Ragonnet, James M. Trauer Eur Respir J, 54 (4) 1900353; 10.1183/13993003.00353-2019
Generalised mosaicism for TSC2 mutation in isolated lymphangioleiomyomatosis Barbara Ogórek, Lana Hamieh, Kathryn Lasseter, Shefali Bagwe, Tania Machado, Carmen Herranz-Ors, Aaron R. Thorner, Anwesha Nag, Peter Gulleman, Krinio Giannikou, Lisa R. Young, Miquel Àngel Pujana, Thomas N. Darling, Souheil El-Chemaly, Joel Moss, Elizabeth P. Henske, David J. Kwiatkowski Eur Respir J, 54 (4) 1900938; 10.1183/13993003.00938-2019

Correspondence

Electrical impedance tomography for chest imaging in acute respiratory failure Inéz Frerichs, Zhanqi Zhao Eur Respir J, 54 (4) 1901497; 10.1183/13993003.01497-2019
Electrical impedance tomography for chest imaging in acute respiratory failure Davide Chiumello, Giuseppe Francesco Sferrazza Papa Eur Respir J, 54 (4) 1901657; 10.1183/13993003.01657-2019
On the valid publication of names of mycobacteria Aharon Oren, Martha E. Trujillo Eur Respir J, 54 (4) 1901483; 10.1183/13993003.01483-2019
On the valid publication of names of mycobacteria Enrico Tortoli Eur Respir J, 54 (4) 1901623; 10.1183/13993003.01623-2019
Is CRP-guided antibiotic treatment a safe way to reduce antibiotic use in severe hospitalised patients with exacerbations of COPD? Marc Miravitlles, Carl Llor, Lars Bjerrum, Sanjay Sethi, Antonio Anzueto Eur Respir J, 54 (4) 1901405; 10.1183/13993003.01405-2019
Is CRP-guided antibiotic treatment a safe way to reduce antibiotic use in severe hospitalised patients with exacerbations of COPD? Henk-Jan Prins, Tjip S. van der Werf, Wim G. Boersma Eur Respir J, 54 (4) 1901597; 10.1183/13993003.01597-2019
A transcutaneous carbon dioxide monitor is a useful tool with known caveats Mauro Maniscalco, Salvatore Fuschillo Eur Respir J, 54 (4) 1900918; 10.1183/13993003.00918-2019
Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux Chris Ward, Zelal Jaber Kharaba Eur Respir J, 54 (4) 1901376; 10.1183/13993003.01376-2019
Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux Jeanne-Marie Perotin, Ratko Djukanovic, Donna E. Davies Eur Respir J, 54 (4) 1901805; 10.1183/13993003.01805-2019
A roadmap for management of chronic thromboembolic pulmonary hypertension Xavier Jaïs, Philippe Brenot, David Montani, Elie Fadel, Marc Humbert, Gérald Simonneau Eur Respir J, 54 (4) 1901295; 10.1183/13993003.01295-2019
Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: is Europe behind? Irene M. Lang, Hiromi Matsubara Eur Respir J, 54 (4) 1901639; 10.1183/13993003.01639-2019

Author correction

“Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: is Europe behind?” Irene M. Lang and Hiromi Matsubara. Eur Respir J 2019; 53: 1900843. Eur Respir J, 54 (4) 1950843; 10.1183/13993003.50843-2019