European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

March

Electronic resources

ERJ March Podcast: Novel therapies in idiopathic pulmonary fibrosis Eur Respir J, 53 (3) 19E5303; 10.1183/13993003.E5303-2019

Editorials

The new haemodynamic definition of pulmonary hypertension: evidence prevails, finally! Marius M. Hoeper, Marc Humbert Eur Respir J, 53 (3) 1900038; 10.1183/13993003.00038-2019
Proposed new pulmonary hypertension definition: is 4 mm(Hg) worth re-writing medical textbooks? J. Simon R. Gibbs, Adam Torbicki Eur Respir J, 53 (3) 1900197; 10.1183/13993003.00197-2019
Tuberculosis research questions identified through the WHO policy guideline development process Nebiat Gebreselassie, Dennis Falzon, Matteo Zignol, Tereza Kasaeva Eur Respir J, 53 (3) 1802407; 10.1183/13993003.02407-2018
The worldwide assessment of separation of patients from ventilatory assistance (WEAN SAFE) ERS Clinical Research Collaboration Leo Heunks, Giacomo Bellani, Tài Pham, Laurent Brochard, John G. Laffey Eur Respir J, 53 (3) 1802228; 10.1183/13993003.02228-2018
Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration Alvar Agusti, Rosa Faner, Gavin Donaldson, Elise Heuvelin, Robab Breyer-Kohansal, Erik Melén, Anke H. Maitland-van der Zee, Jørgen Vestbo, James P. Allinson, Lowie E.G.W. Vanfleteren, Maarten van den Berge, Ian M. Adcock, Lies Lahousse, Guy Brusselle, Jadwiga A. Wedzicha Eur Respir J, 53 (3) 1900217; 10.1183/13993003.00217-2019
Towards precision medicine: CCL2, another brick in the wall? Andriani Charpidou, Elias Kotteas, Mina Gaga Eur Respir J, 53 (3) 1802327; 10.1183/13993003.02327-2018
Lessons from tracheal tube development for understanding congenital tracheal malformations Heena Kumra, Neha E.H. Dinesh, Dieter P. Reinhardt Eur Respir J, 53 (3) 1900127; 10.1183/13993003.00127-2019
TB, you're a long time cured James M. Trauer Eur Respir J, 53 (3) 1900104; 10.1183/13993003.00104-2019
Molecular endpoints for establishing target engagement by novel idiopathic pulmonary fibrosis therapies Paul J. Wolters, Vincent Cottin Eur Respir J, 53 (3) 1900283; 10.1183/13993003.00283-2019

Pulmonary vascular disease

The ADAMTS13–VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension Michael Newnham, Kieron South, Marta Bleda, William R. Auger, Joan A. Barberà, Harm Bogaard, Katherine Bunclark, John E. Cannon, Marion Delcroix, Charaka Hadinnapola, Luke S. Howard, David Jenkins, Eckhard Mayer, Choo Ng, Christopher J. Rhodes, Nicholas Screaton, Karen Sheares, Michael A. Simpson, Mark Southwood, Li Su, Dolores Taboada, Matthew Traylor, Richard C. Trembath, Sofia S. Villar, Martin R. Wilkins, John Wharton, Stefan Gräf, Joanna Pepke-Zaba, Michael Laffan, David A. Lane, Nicholas W. Morrell, Mark Toshner Eur Respir J, 53 (3) 1801805; 10.1183/13993003.01805-2018

Cystic fibrosis

Cystic fibrosis and basic science

Targeting of cathepsin S reduces cystic fibrosis-like lung disease Donna M. Small, Ryan R. Brown, Declan F. Doherty, Anthony Abladey, Zhe Zhou-Suckow, Rebecca J. Delaney, Lauren Kerrigan, Caoifa M. Dougan, Keren S. Borensztajn, Leslie Holsinger, Robert Booth, Christopher J. Scott, Guillermo López-Campos, J. Stuart Elborn, Marcus A. Mall, Sinéad Weldon, Clifford C. Taggart Eur Respir J, 53 (3) 1801523; 10.1183/13993003.01523-2018

Basic science

Neutrophils disturb pulmonary microcirculation in sepsis-induced acute lung injury Inwon Park, Mingyo Kim, Kibaek Choe, Eunjoo Song, Howon Seo, Yoonha Hwang, Jinhyo Ahn, Seung-Hyo Lee, Jae Hyuk Lee, You Hwan Jo, Kyuseok Kim, Gou Young Koh, Pilhan Kim Eur Respir J, 53 (3) 1800786; 10.1183/13993003.00786-2018
Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis Wenguang Yin, Hyun-Taek Kim, ShengPeng Wang, Felix Gunawan, Rui Li, Carmen Buettner, Beate Grohmann, Gerhard Sengle, Debora Sinner, Stefan Offermanns, Didier Y.R. Stainier Eur Respir J, 53 (3) 1800840; 10.1183/13993003.00840-2018

Lung structure and function

Lung cancer and imaging

Predicting EGFR mutation status in lung adenocarcinoma on computed tomography image using deep learning Shuo Wang, Jingyun Shi, Zhaoxiang Ye, Di Dong, Dongdong Yu, Mu Zhou, Ying Liu, Olivier Gevaert, Kun Wang, Yongbei Zhu, Hongyu Zhou, Zhenyu Liu, Jie Tian Eur Respir J, 53 (3) 1800986; 10.1183/13993003.00986-2018

Lung cancer

Which definition of a central tumour is more predictive of occult mediastinal metastasis in nonsmall cell lung cancer patients with radiological N0 disease? Sun Hye Shin, Dong Young Jeong, Kyung Soo Lee, Jong Ho Cho, Yong Soo Choi, Kyungjong Lee, Sang-Won Um, Hojoong Kim, Byeong-Ho Jeong Eur Respir J, 53 (3) 1801508; 10.1183/13993003.01508-2018
Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for nonsmall cell lung cancer therapy Jun Lu, Hua Zhong, Tianqing Chu, Xueyan Zhang, Rong Li, Jiayuan Sun, Runbo Zhong, Yuqin Yang, Mohammad Shah Alam, Yuqing Lou, Jianlin Xu, Yanwei Zhang, Jun Wu, Xiaowei Li, Xiaodong Zhao, Kai Li, Liming Lu, Baohui Han Eur Respir J, 53 (3) 1801562; 10.1183/13993003.01562-2018

COPD

Dual bronchodilation with tiotropium/olodaterol further reduces activity-related breathlessness versus tiotropium alone in COPD François Maltais, Joseph-Leon Aumann, Anne-Marie Kirsten, Éric Nadreau, Hemani Macesic, Xidong Jin, Alan Hamilton, Denis E. O'Donnell Eur Respir J, 53 (3) 1802049; 10.1183/13993003.02049-2018
Serum levels of hyaluronic acid are associated with COPD severity and predict survival Eleni Papakonstantinou, Ioannis Bonovolias, Michael Roth, Michael Tamm, Desiree Schumann, Florent Baty, Renaud Louis, Branislava Milenkovic, Wim Boersma, Bram Stieltjes, Konstantinos Kostikas, Francesco Blasi, Joachim G. Aerts, Gernot G.U. Rohde, Alicia Lacoma, Antoni Torres, Tobias Welte, Daiana Stolz Eur Respir J, 53 (3) 1801183; 10.1183/13993003.01183-2018

Infection

Patient-reported outcome measures in the recovery of adults hospitalised with community-acquired pneumonia: a systematic review Harry J. Pick, Charlotte E. Bolton, Wei Shen Lim, Tricia M. McKeever Eur Respir J, 53 (3) 1802165; 10.1183/13993003.02165-2018

Infection and tuberculosis

Chronic pulmonary aspergillosis commonly complicates treated pulmonary tuberculosis with residual cavitation Iain D. Page, Rosemary Byanyima, Sharath Hosmane, Nathan Onyachi, Cyprian Opira, Malcolm Richardson, Richard Sawyer, Anna Sharman, David W. Denning Eur Respir J, 53 (3) 1801184; 10.1183/13993003.01184-2018

Tuberculosis

Adjunctive vitamin D in tuberculosis treatment: meta-analysis of individual participant data David A. Jolliffe, Davaasambuu Ganmaa, Christian Wejse, Rubhana Raqib, M. Ahsanul Haq, Nawal Salahuddin, Peter K. Daley, Anna P. Ralph, Thomas R. Ziegler, Adrian R. Martineau Eur Respir J, 53 (3) 1802003; 10.1183/13993003.02003-2018

Interstitial lung diseases

A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis Pauline T. Lukey, Stephen A. Harrison, Shuying Yang, Yim Man, Beverley F. Holman, Alaleh Rashidnasab, Gabrielle Azzopardi, Michael Grayer, Juliet K. Simpson, Philippe Bareille, Lyn Paul, Hannah V. Woodcock, Richard Toshner, Peter Saunders, Philip L. Molyneaux, Kris Thielemans, Frederick J. Wilson, Paul F. Mercer, Rachel C. Chambers, Ashley M. Groves, William A. Fahy, Richard P. Marshall, Toby M. Maher Eur Respir J, 53 (3) 1801992; 10.1183/13993003.01992-2018
Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis Nasreen Khalil, Helene Manganas, Christopher J. Ryerson, Shane Shapera, Andre M. Cantin, Paul Hernandez, Eric E. Turcotte, Joseph M. Parker, John E. Moran, Gary R. Albert, Renata Sawtell, Aline Hagerimana, Pierre Laurin, Lyne Gagnon, Frank Cesari, Martin Kolb Eur Respir J, 53 (3) 1800663; 10.1183/13993003.00663-2018
The added value of comorbidities in predicting survival in idiopathic pulmonary fibrosis: a multicentre observational study Sebastiano Emanuele Torrisi, Brett Ley, Michael Kreuter, Marlies Wijsenbeek, Eric Vittinghoff, Harold R. Collard, Carlo Vancheri Eur Respir J, 53 (3) 1801587; 10.1183/13993003.01587-2018

ERJ Methods

Making sense of cost-effectiveness analyses in respiratory medicine: a practical guide for non-health economists Job F.M. van Boven, Susanne J. van de Hei, Mohsen Sadatsafavi Eur Respir J, 53 (3) 1801816; 10.1183/13993003.01816-2018

Research letters

Lung elastic recoil and ventilation heterogeneity of diffusion-dependent airways in older people with asthma and fixed airflow obstruction Katrina O. Tonga, Norbert Berend, Cindy Thamrin, Claude S. Farah, Kanika Jetmalani, David G. Chapman, Gregory G. King Eur Respir J, 53 (3) 1801028; 10.1183/13993003.01028-2018
Low transmission risk of Pseudomonas aeruginosa in a bronchiectasis clinic based on the knowledge of bacterial population biology Nina Cramer, Ludwig Sedlacek, Burkhard Tümmler, Tobias Welte Eur Respir J, 53 (3) 1802191; 10.1183/13993003.02191-2018
Effect of daily azithromycin therapy and adherence on readmission risk in COPD Jamuna K. Krishnan, Helen Voelker, John E. Connett, Dennis E. Niewoehner, Richard K. Albert, Paul D. Scanlon, Gerard J. Criner, Mark T. Dransfield, MeiLan K. Han, Fernando J. Martinez Eur Respir J, 53 (3) 1801377; 10.1183/13993003.01377-2018
Restricted visiting reduces nosocomial viral respiratory tract infections in high-risk neonates Lisa Szatkowski, Rebecca McClaughry, Martin Clarkson, Don Sharkey Eur Respir J, 53 (3) 1801874; 10.1183/13993003.01874-2018
Quantitative analysis of lung sounds for monitoring idiopathic pulmonary fibrosis: a prospective pilot study Giacomo Sgalla, Anna Rita Larici, Nicola Sverzellati, Brian Bartholmai, Simon L.F. Walsh, Dragana Nikolic, Anna Barney, Sophie Fletcher, Mark Jones, Donna D Davies, Luca Richeldi Eur Respir J, 53 (3) 1802093; 10.1183/13993003.02093-2018
Lung function and oral health in adolescents Joachim Heinrich, Elisabeth Thiering, Rudolf A. Jörres, Holger Schulz, Jan Kühnisch, Marie Standl Eur Respir J, 53 (3) 1801951; 10.1183/13993003.01951-2018

Correspondence

Still puzzling about a clear definition of pulmonary arterial hypertension in newborns Giuseppe Calcaterra, Vassilios Fanos, Pier Paolo Bassareo Eur Respir J, 53 (3) 1900005; 10.1183/13993003.00005-2019
Response: Still puzzling about a clear definition of pulmonary arterial hypertension in newborns Erika B. Rosenzweig, Steven H. Abman, Rolf M.F. Berger Eur Respir J, 53 (3) 1900135; 10.1183/13993003.00135-2019
Pulmonary fibrosis: “idiopathic” is not “cryptogenic” Vincent Cottin Eur Respir J, 53 (3) 1802314; 10.1183/13993003.02314-2018
Pulmonary fibrosis: “idiopathic” is not “cryptogenic” Athol U. Wells, Kevin K. Brown, Kevin R. Flaherty, Martin Kolb, Victor J. Thannickal Eur Respir J, 53 (3) 1900400; 10.1183/13993003.00400-2019
Tolerability of rifapentine-based regimens in latent tuberculosis infection treatment in the elderly Pei-Chun Chan, Pin-Hui Lee, Min-Ju Lu, You-Chieh Huang, Teng-Yi Feng, Wen-Wen Chen, Chia-Chi Lee, Yen-Fang Huang, Chen-Yuan Chiang Eur Respir J, 53 (3) 1802396; 10.1183/13993003.02396-2018
Pulmonary hypertension associated with left heart disease: efforts to improve the meaning of haemodynamic phenotypes Juan C. Grignola, Pedro Trujillo, Enric Domingo Eur Respir J, 53 (3) 1801894; 10.1183/13993003.01894-2018
Pulmonary hypertension associated with left heart disease: efforts to improve the meaning of haemodynamic phenotypes Christian Gerges, Mario Gerges, Irene M. Lang Eur Respir J, 53 (3) 1802393; 10.1183/13993003.02393-2018