European Respiratory Journal

The ERJ publishes clinical and experimental work relating to all aspects of adult and paediatric respiratory medicine, including cell biology, epidemiology, immunology, oncology, pathophysiology, imaging, occupational medicine, intensive care, sleep medicine and thoracic surgery. In addition to original research material, the ERJ also publishes editorial commentaries, reviews, short research letters and correspondence to the editor. Articles are published continuously and collected into 12 monthly issues in two volumes per year.

October

ERJ October Podcast: Lessons from IPF clinical trials over the past 25 years Eur Respir J, 50 (4) 17E5004; 10.1183/13993003.E5004-2017
A risky political game with climate change Mehdi Mirsaeidi, Abdy Javadzadeh, Michael Campos Eur Respir J, 50 (4) 1701145; 10.1183/13993003.01145-2017
A unique event for the francophone respiratory community Louis-Philippe Boulet, Elyse Bissonnette, Marc Humbert, Bernard Maître, Bernard Pigearias Eur Respir J, 50 (4) 1701479; 10.1183/13993003.01479-2017
Pharmacological treatment optimisation for stable COPD: an endless story? Maeva Zysman, François Chabot, Bruno Housset, Capucine Morelot Panzini, Philippe Devillier, Nicolas Roche Eur Respir J, 50 (4) 1701250; 10.1183/13993003.01250-2017
Management of hypertension in obstructive sleep apnoea: predicting blood pressure reduction under continuous positive airway pressure Renaud Tamisier, Patrick Lévy Eur Respir J, 50 (4) 1701822; 10.1183/13993003.01822-2017
Treatment of sarcoidosis-associated pulmonary hypertension: so close, and yet so far Robert P. Baughman, Oksana A. Shlobin Eur Respir J, 50 (4) 1701725; 10.1183/13993003.01725-2017
Mucolytics for COPD: negotiating a slippery slope towards proof of efficacy Shawn D. Aaron Eur Respir J, 50 (4) 1701465; 10.1183/13993003.01465-2017
Morphine to relieve exertional dyspnoea in COPD: myth, dream or reality? Louis Laviolette, Pierantonio Laveneziana Eur Respir J, 50 (4) 1701865; 10.1183/13993003.01865-2017
Next generation of anti-inflammatory therapy for COPD? Henrik Watz Eur Respir J, 50 (4) 1702084; 10.1183/13993003.02084-2017
Are inhaled corticosteroids increasing the “load” for some patients with COPD? Tom M.A. Wilkinson Eur Respir J, 50 (4) 1701848; 10.1183/13993003.01848-2017
Occupational exposure and asthma control Dick Heederik Eur Respir J, 50 (4) 1701951; 10.1183/13993003.01951-2017
The Art of Breathing: Synergy Tom Kotsimbos Eur Respir J, 50 (4) 1705004; 10.1183/13993003.05004-2017
Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring Anabel L. Castro-Grattoni, Gerard Torres, Montserrat Martínez-Alonso, Ferran Barbé, Cecilia Turino, Alicia Sánchez-de-la-Torre, Anunciacion Cortijo, Joaquin Duran-Cantolla, Carlos Egea, Gonzalo Cao, Manuel Sánchez-de-la-Torre Eur Respir J, 50 (4) 1700651; 10.1183/13993003.00651-2017
Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea Carolina Cubillos-Zapata, Jose Avendaño-Ortiz, Enrique Hernandez-Jimenez, Victor Toledano, Jose Casas-Martin, Anibal Varela-Serrano, Marta Torres, Isaac Almendros, Raquel Casitas, Isabel Fernández-Navarro, Aldara Garcia-Sanchez, Luis A. Aguirre, Ramón Farre, Eduardo López-Collazo, Francisco García-Rio Eur Respir J, 50 (4) 1700833; 10.1183/13993003.00833-2017
Inter-test reproducibility of the lung clearance index measured by multiple breath washout Esther Oude Engberink, Felix Ratjen, Stephanie D. Davis, George Retsch-Bogart, Reshma Amin, Sanja Stanojevic Eur Respir J, 50 (4) 1700433; 10.1183/13993003.00433-2017
Combined measurement of carbon monoxide and nitric oxide lung transfer does not improve the identification of pulmonary hypertension in systemic sclerosis Bruno Degano, Thibaud Soumagne, Thomas Delaye, Patrick Berger, Thierry Perez, Alicia Guillien, Jean-Luc Pellegrin, David Launay, Nadine Magy-Bertrand, Christian Agard, Kiet Phong Tiev, Thông Hua-Huy, Catherine Tardiff, Véronique Diaz, Arnaud Chambellan, Anh Tuan Dinh-Xuan Eur Respir J, 50 (4) 1701008; 10.1183/13993003.01008-2017
Management and long-term outcomes of sarcoidosis-associated pulmonary hypertension Athénaïs Boucly, Vincent Cottin, Hilario Nunes, Xavier Jaïs, Abdelatif Tazi, Grégoire Prévôt, Martine Reynaud-Gaubert, Claire Dromer, Catherine Viacroze, Delphine Horeau-Langlard, Christophe Pison, Emmanuel Bergot, Julie Traclet, Jason Weatherald, Gérald Simonneau, Dominique Valeyre, David Montani, Marc Humbert, Olivier Sitbon, Laurent Savale Eur Respir J, 50 (4) 1700465; 10.1183/13993003.00465-2017
Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study Roberto W. Dal Negro, Jadwiga A. Wedzicha, Martin Iversen, Giovanni Fontana, Clive Page, Arrigo F. Cicero, Edoardo Pozzi, Peter M.A. Calverley Eur Respir J, 50 (4) 1700711; 10.1183/13993003.00711-2017
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort Viktoriya L. Kim, Ngaire A. Coombs, Karl J. Staples, Kristoffer K. Ostridge, Nicholas P. Williams, Stephen A. Wootton, Jeanne-Marie Devaster, Emmanuel Aris, Stuart C. Clarke, Andrew C. Tuck, Simon C. Bourne, Tom M.A. Wilkinson Eur Respir J, 50 (4) 1700853; 10.1183/13993003.00853-2017
Effect of morphine on breathlessness and exercise endurance in advanced COPD: a randomised crossover trial Sara J. Abdallah, Courtney Wilkinson-Maitland, Nathalie Saad, Pei Zhi Li, Benjamin M. Smith, Jean Bourbeau, Dennis Jensen Eur Respir J, 50 (4) 1701235; 10.1183/13993003.01235-2017
RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-a and -? selectivity, suppresses COPD inflammation Catherine E. Charron, Paul Russell, Kazuhiro Ito, Simon Lea, Yasuo Kizawa, Charlie Brindley, Dave Singh Eur Respir J, 50 (4) 1700188; 10.1183/13993003.00188-2017
Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD Marco Contoli, Alessia Pauletti, Maria Rita Rossi, Antonio Spanevello, Paolo Casolari, Andrea Marcellini, Giacomo Forini, Giulia Gnesini, Brunilda Marku, Neil Barnes, Andrea Rizzi, Giacomo Curradi, Gaetano Caramori, Paolo Morelli, Alberto Papi Eur Respir J, 50 (4) 1700451; 10.1183/13993003.00451-2017
A virtual asthma clinic for children: fewer routine outpatient visits, same asthma control Lara S. van den Wijngaart, Jolt Roukema, Annemie L.M. Boehmer, Marianne L. Brouwer, Cindy A.C. Hugen, Laetitia E.M. Niers, Arwen J. Sprij, Eleonora R.V.M. Rikkers-Mutsaerts, Bart L. Rottier, A. Rogier T. Donders, Chris M. Verhaak, Mariëlle W. Pijnenburg, Peter J.F.M. Merkus Eur Respir J, 50 (4) 1700471; 10.1183/13993003.00471-2017
Characterisation of asthma subgroups associated with circulating YKL-40 levels Jose L. Gomez, Xiting Yan, Carole T. Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova, Deborah A. Meyers, Eugene R. Bleecker, Gina M. Crisafi, Nizar N. Jarjour, Linda Rogers, Joan Reibman, Geoffrey L. Chupp Eur Respir J, 50 (4) 1700800; 10.1183/13993003.00800-2017
Occupational exposure to disinfectants and asthma control in US nurses Orianne Dumas, Aleta S. Wiley, Catherine Quinot, Raphaëlle Varraso, Jan-Paul Zock, Paul K. Henneberger, Frank E. Speizer, Nicole Le Moual, Carlos A. Camargo Eur Respir J, 50 (4) 1700237; 10.1183/13993003.00237-2017
Traffic-related air pollution exposure over a 5-year period is associated with increased risk of asthma and poor lung function in middle age Gayan Bowatte, Bircan Erbas, Caroline J. Lodge, Luke D. Knibbs, Lyle C. Gurrin, Guy B. Marks, Paul S. Thomas, David P. Johns, Graham G. Giles, Jennie Hui, Martine Dennekamp, Jennifer L. Perret, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage Eur Respir J, 50 (4) 1602357; 10.1183/13993003.02357-2016
Association between lung cancer somatic mutations and occupational exposure in never-smokers Christophe Paris, Pascal Do, Bénédicte Mastroianni, Adrien Dixmier, Patrick Dumont, Eric Pichon, Christos Chouaid, Bruno Coudert, Pascal Foucher, Séverine Fraboulet, Myriam Locatelli-Sanchez, Nathalie Baize, Eric Dansin, Lionel Moreau, Michel Vincent, Pascale Missy, Franck Morin, Denis Moro-Sibilot, Sébastien Couraud Eur Respir J, 50 (4) 1700716; 10.1183/13993003.00716-2017
Th17 cytokines: novel potential therapeutic targets for COPD pathogenesis and exacerbations Olivier Le Rouzic, Muriel Pichavant, Emilie Frealle, Antoine Guillon, Mustapha Si-Tahar, Philippe Gosset Eur Respir J, 50 (4) 1602434; 10.1183/13993003.02434-2016
Idiopathic pulmonary fibrosis: lessons from clinical trials over the past 25 years Ganesh Raghu Eur Respir J, 50 (4) 1701209; 10.1183/13993003.01209-2017
What is precision medicine? Inke R. König, Oliver Fuchs, Gesine Hansen, Erika von Mutius, Matthias V. Kopp Eur Respir J, 50 (4) 1700391; 10.1183/13993003.00391-2017
Precision medicine in airway diseases: moving to clinical practice Alvar Agustí, Mona Bafadhel, Richard Beasley, Elisabeth H. Bel, Rosa Faner, Peter G. Gibson, Renaud Louis, Vanessa M. McDonald, Peter J. Sterk, Mike Thomas, Claus Vogelmeier, Ian D. Pavord Eur Respir J, 50 (4) 1701655; 10.1183/13993003.01655-2017
Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis Sébastien Boutin, Simon Y. Graeber, Mirjam Stahl, A. Susanne Dittrich, Marcus A. Mall, Alexander H. Dalpke Eur Respir J, 50 (4) 1701086; 10.1183/13993003.01086-2017
Endothelial dysfunction and increased platelet reactivity in patients with acute coronary syndrome and undiagnosed COPD: insights into the SCAP trial Rita Pavasini, Francesco Vieceli dalla Sega, Francesco Gallo, Giulia Passarini, Alberto Papi, Marco Contoli, Gianluca Campo Eur Respir J, 50 (4) 1701183; 10.1183/13993003.01183-2017
Online asthma management for children is cost-effective Lara S. van den Wijngaart, Wietske Kievit, Jolt Roukema, Annemie L.M. Boehmer, Marianne L. Brouwer, Cindy A.C. Hugen, Laetitia E.M. Niers, Arwen J. Sprij, Eleonora R.V.M. Rikkers-Mutsaerts, Bart L. Rottier, Chris M. Verhaak, Mariëlle W. Pijnenburg, Peter J.F.M. Merkus Eur Respir J, 50 (4) 1701413; 10.1183/13993003.01413-2017
The role of ethnicity in the upper airway in a Belgian paediatric population with obstructive sleep apnoea Monique Slaats, Wim Vos, Cedric Van Holsbeke, Jan De Backer, Dieter Loterman, Wilfried De Backer, An Boudewyns, Stijn Verhulst Eur Respir J, 50 (4) 1701278; 10.1183/13993003.01278-2017
BRAF and NRAS mutations in circulating Langerhans-like CD1a⁺ cells in a patient with pulmonary Langerhans’ cell histiocytosis Li Zhang, Gustavo Pacheco-Rodriguez, Wendy K. Steagall, Jiro Kato, Thomas V. Colby, Mary Haughey, Joel Moss Eur Respir J, 50 (4) 1700521; 10.1183/13993003.00521-2017
Evaluation of tuberculosis screening of immigrants in the Netherlands Sarah van de Berg, Connie Erkens, Job van Rest, Susan van den Hof, Margreet Kamphorst, Sytze Keizer, Gerard de Vries Eur Respir J, 50 (4) 1700977; 10.1183/13993003.00977-2017
Passive smoking in relation to lung cancer incidence and histologic types in Norwegian adults: the HUNT study Yi-Qian Sun, Yue Chen, Arnulf Langhammer, Frank Skorpen, Chunsen Wu, Xiao-Mei Mai Eur Respir J, 50 (4) 1700824; 10.1183/13993003.00824-2017
Prospective study of body mass index and risk of sarcoidosis in US women Orianne Dumas, Krislyn M. Boggs, Yvette C. Cozier, Meir J. Stampfer, Carlos A. Camargo Eur Respir J, 50 (4) 1701397; 10.1183/13993003.01397-2017
Effect of pirfenidone on cough in patients with idiopathic pulmonary fibrosis Mirjam J.G. van Manen, Surinder S. Birring, Carlo Vancheri, Virginia Vindigni, Elisabetta Renzoni, Anne-Marie Russell, Monique Wapenaar, Vincent Cottin, Marlies S. Wijsenbeek Eur Respir J, 50 (4) 1701157; 10.1183/13993003.01157-2017
Do admission glucose levels aid in predicting mortality associated with community-acquired pneumonia? Douwe F. Postma, Cornelis H. van Werkhoven, Darren P.R. Troeman, Sanjay U.C. Sankatsing, Jan Jelrik Oosterheert, Marc J.M. Bonten Eur Respir J, 50 (4) 1700307; 10.1183/13993003.00307-2017
Tuberculosis screening in asylum seekers in Germany, 2015: characteristics of cases and yield Lena Fiebig, Barbara Hauer, Marta Andrés, Walter Haas Eur Respir J, 50 (4) 1602550; 10.1183/13993003.02550-2016
Mycobacterium tuberculosis transmission from patients with drug-resistant compared to drug-susceptible TB: a systematic review and meta-analysis Chiori Kodama, Berit Lange, Ioana D. Olaru, Palwasha Khan, Marc Lipman, James A. Seddon, Derek Sloan, Louis Grandjean, Rashida Abbas Ferrand, Katharina Kranzer Eur Respir J, 50 (4) 1701044; 10.1183/13993003.01044-2017
Frequency and significance of indeterminate and borderline Quantiferon Gold TB IGRA results James Brown, Kartik Kumar, Jacob Reading, Jennifer Harvey, Saraswathi Murthy, Santino Capocci, Susan Hopkins, Suranjith Seneviratne, Ian Cropley, Marc Lipman Eur Respir J, 50 (4) 1701267; 10.1183/13993003.01267-2017
Crowdfunding for respiratory research: a new frontier for patient and public engagement? Darrin P. Wiebe, J. Mark FitzGerald Eur Respir J, 50 (4) 1701333; 10.1183/13993003.01333-2017
High-dose isoniazid in the shorter-course multidrug-resistant tuberculosis regimen in the Republic of Moldova Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Jan Heyckendorf, Valeriu Crudu Eur Respir J, 50 (4) 1701340; 10.1183/13993003.01340-2017
A katG 315 mutation alone should not lead to exclusion of isoniazid in treatment of multidrug-resistant tuberculosis Einar Heldal Eur Respir J, 50 (4) 1701696; 10.1183/13993003.01696-2017
Lack of evidence of isoniazid efficacy for the treatment of MDR/XDR-TB in the presence of the katG 315T mutation Dumitru Chesov, Nelly Ciobanu, Christoph Lange, Thomas Schön, Jan Heyckendorf, Valeriu Crudu Eur Respir J, 50 (4) 1701752; 10.1183/13993003.01752-2017
Xpert MTB/RIF Ultra: the long-awaited game changer for tuberculous meningitis? Jerome H. Chin Eur Respir J, 50 (4) 1701201; 10.1183/13993003.01201-2017
Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how “large” your diagnostic criteria are Giulio Rossi, Lucia Longo, Fausto Barbieri, Federica Bertolini, Paolo Spagnolo Eur Respir J, 50 (4) 1701292; 10.1183/13993003.01292-2017
Why we should improve current practice of diagnosing and treating pulmonary large cell neuroendocrine carcinomas in patients with advanced disease Jules Derks, Robert Jan van Suylen, Erik Thunnissen, Michael den Bakker, Harry Groen, Egbert Smit, Ronald Damhuis, Esther van den Broek, Ernst-Jan Speel, Anne-Marie C. Dingemans Eur Respir J, 50 (4) 1701658; 10.1183/13993003.01658-2017
“Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies.” Geoffrey Chupp, Michel Laviolette, Lauren Cohn, Charlene McEvoy, Sandeep Bansal, Adrian Shifren, Sumita Khatri, G. Mark Grubb, Edmund McMullen, Racho Strauven and Joel N. Kline. Eur Respir J 2017; 50: 1700017. Eur Respir J, 50 (4) 1750017; 10.1183/13993003.50017-2017