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April

Interstitial lung disease in primary immunodeficiency: towards a brighter future John R. Hurst, Klaus Warnatz Eur Respir J, 55 (4) 2000089; 10.1183/13993003.00089-2020
Making the case for causality: what role do lung microbiota play in idiopathic pulmonary fibrosis? Robert P. Dickson, Sergio Harari, Martin Kolb Eur Respir J, 55 (4) 2000318; 10.1183/13993003.00318-2020
Leveraging early markers of cystic fibrosis structural lung disease to improve outcomes Patrick A. Flume, Donald R. VanDevanter Eur Respir J, 55 (4) 2000105; 10.1183/13993003.00105-2020
NETs: a new biomarker of traffic-related air pollution exposure: are they ready to catch fish? Howard M Kipen, Debra L. Laskin Eur Respir J, 55 (4) 2000305; 10.1183/13993003.00305-2020
Vanishing vessels aboding pulmonary disease: a role for VEGFR2 Liza Botros, Anton Vonk Noordegraaf, Jurjan Aman Eur Respir J, 55 (4) 2000326; 10.1183/13993003.00326-2020
A new breeze from an inspiring past: normality with multiple breath washout in school-aged children Anne-Christianne Kentgens, Marc Oppelaar, Peter Merkus Eur Respir J, 55 (4) 2000485; 10.1183/13993003.00485-2020
Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent Rachele Invernizzi, Joseph Barnett, Bhavin Rawal, Arjun Nair, Poonam Ghai, Shaun Kingston, Felix Chua, Zhe Wu, Athol U. Wells, Elizabeth R. Renzoni, Andrew G. Nicholson, Alexandra Rice, Clare M. Lloyd, Adam J. Byrne, Toby M. Maher, Anand Devaraj, Philip L. Molyneaux Eur Respir J, 55 (4) 1901519; 10.1183/13993003.01519-2019
Acute exacerbation of idiopathic pulmonary fibrosis: international survey and call for harmonisation Michael Kreuter, Markus Polke, Simon L.F. Walsh, Johannes Krisam, Harold R. Collard, Nazia Chaudhuri, Sergey Avdeev, Jürgen Behr, Gregory Calligaro, Tamera Corte, Kevin Flaherty, Manuela Funke-Chambour, Martin Kolb, Yasuhiro Kondoh, Toby M. Maher, Maria Molina Molina, Antonio Morais, Catharina C. Moor, Julie Morisset, Carlos Pereira, Silvia Quadrelli, Moises Selman, Argyrios Tzouvelekis, Claudia Valenzuela, Carlo Vancheri, Vanesa Vicens-Zygmunt, Julia Wälscher, Wim Wuyts, Marlies Wijsenbeek, Vincent Cottin, Elisabeth Bendstrup Eur Respir J, 55 (4) 1901760; 10.1183/13993003.01760-2019
Early markers of cystic fibrosis structural lung disease: follow-up of the ACFBAL cohort Naomi E. Wijker, Suzanna Vidmar, Keith Grimwood, Peter D. Sly, Catherine A. Byrnes, John B. Carlin, Peter J. Cooper, Colin F. Robertson, R. John Massie, Mariette P.C. Kemner van de Corput, Joyce Cheney, Harm A.W.M. Tiddens, Claire E. Wainwright Eur Respir J, 55 (4) 1901694; 10.1183/13993003.01694-2019
Acute air pollution exposure alters neutrophils in never-smokers and at-risk humans Denise J. Wooding, Min Hyung Ryu, Hang Li, Neil E. Alexis, Olga Pena, Chris Carlsten Eur Respir J, 55 (4) 1901495; 10.1183/13993003.01495-2019
Familial pulmonary arterial hypertension by KDR heterozygous loss of function Mélanie Eyries, David Montani, Barbara Girerd, Nicolas Favrolt, Marianne Riou, Laurence Faivre, Grégoire Manaud, Frédéric Perros, Stefan Gräf, Nicholas W. Morrell, Marc Humbert, Florent Soubrier Eur Respir J, 55 (4) 1902165; 10.1183/13993003.02165-2019
Normative data for multiple breath washout outcomes in school-aged Caucasian children Pinelopi Anagnostopoulou, Philipp Latzin, Renee Jensen, Mirjam Stahl, Alana Harper, Sophie Yammine, Jakob Usemann, Rachel E. Foong, Ben Spycher, Graham L. Hall, Florian Singer, Sanja Stanojevic, Marcus A. Mall, Felix Ratjen, Kathryn A. Ramsey Eur Respir J, 55 (4) 1901302; 10.1183/13993003.01302-2019
Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge Claus Bachert, Marc Humbert, Nicola A. Hanania, Nan Zhang, Stephen Holgate, Roland Buhl, Barbara M. Bröker Eur Respir J, 55 (4) 1901592; 10.1183/13993003.01592-2019
NORDSTAR: paving the way for a new era in asthma research Kirk Geale, Hatef Darabi, Maria Lindh, Hanna Fues Wahl, Oskar Ström, Hui Cao, Luisa Alvares, Rikke Dodge, Emil Loefroth, Alan Altraja, Vibeke Backer, Helena Backman, Leif Bjermer, Apostolos Bossios, Bernt Bøgvald Aarli, Barbro Dahlén, Ole Hilberg, Christer Janson, Hannu Kankaanranta, Jussi Karjalainen, Paula Kauppi, Maritta Kilpeläinen, Sverre Lehmann, Lauri Lehtimäki, Bo Lundbäck, Thomas Sandström, Charlotte Suppli Ulrik, Asger Sverrild, Arja Viinanen, Anna von Bülow, Valentyna Yasinska, Celeste Porsbjerg Eur Respir J, 55 (4) 1902476; 10.1183/13993003.02476-2019
Blood monocyte counts as a potential prognostic marker for idiopathic pulmonary fibrosis: analysis from the Australian IPF registry Alan K.Y. Teoh, Helen E. Jo, Daniel C. Chambers, Karen Symons, Eugene H. Walters, Nicole S. Goh, Ian Glaspole, Wendy Cooper, Paul Reynolds, Yuben Moodley, Tamera J. Corte Eur Respir J, 55 (4) 1901855; 10.1183/13993003.01855-2019
SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium Soyeon Kim, Erick Forno, Qi Yan, Yale Jiang, Rong Zhang, Nadia Boutaoui, Edna Acosta-Pérez, Glorisa Canino, Wei Chen, Juan C. Celedón Eur Respir J, 55 (4) 1902079; 10.1183/13993003.02079-2019
Chronic thromboembolic disease following pulmonary embolism: time for a fresh look at old clot Colm McCabe, Konstantinos Dimopoulos, Alex Pitcher, Elizabeth Orchard, Laura C. Price, Aleksander Kempny, S. John Wort Eur Respir J, 55 (4) 1901934; 10.1183/13993003.01934-2019
Chronic thromboembolic disease following pulmonary embolism: more work ahead Stavros V. Konstantinides Eur Respir J, 55 (4) 2000229; 10.1183/13993003.00229-2020
Strategies for the prevention and management of coronavirus disease 2019 Wei-jie Guan, Rong-chang Chen, Nan-shan Zhong Eur Respir J, 55 (4) 2000597; 10.1183/13993003.00597-2020
Pathogenesis of COVID-19 from a cell biology perspective Robert J. Mason Eur Respir J, 55 (4) 2000607; 10.1183/13993003.00607-2020
Asthma rescue treatments, time to reboot Jeremy Charriot, Mina Gaga, Carey Suehs, Arnaud Bourdin Eur Respir J, 55 (4) 2000542; 10.1183/13993003.00542-2020
Prognostic impact of typical and probable usual interstitial pneumonia pattern in idiopathic pulmonary fibrosis: is the debate about biopsy a Star Wars saga? Martin Kolb, Ganesh Raghu, Athol Wells Eur Respir J, 55 (4) 2000590; 10.1183/13993003.00590-2020
Getting neural about airway gland secretion Gimano D. Amatngalim, Carla M.P. Ribeiro Eur Respir J, 55 (4) 2000466; 10.1183/13993003.00466-2020
IL-6 in pulmonary hypertension: why novel is not always best Mark Toshner, Alex Rothman Eur Respir J, 55 (4) 2000314; 10.1183/13993003.00314-2020
Altered metabolism in pulmonary hypertension: fuelling the fire or just smoke? Daisy Duan, Chenjuan Gu, Jonathan C. Jun Eur Respir J, 55 (4) 2000447; 10.1183/13993003.00447-2020
Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the PRACTICAL study, a randomised clinical trial Christina Baggott, Helen K. Reddel, Jo Hardy, Jenny Sparks, Mark Holliday, Andrew Corin, Barney Montgomery, Jim Reid, Davitt Sheahan, Robert J. Hancox, Mark Weatherall, Richard Beasley, James Fingleton Eur Respir J, 55 (4) 1902073; 10.1183/13993003.02073-2019
Overuse of short-acting ß₂-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme Bright I. Nwaru, Magnus Ekström, Pål Hasvold, Fredrik Wiklund, Gunilla Telg, Christer Janson Eur Respir J, 55 (4) 1901872; 10.1183/13993003.01872-2019
Severe desaturations increase psychomotor vigilance task-based median reaction time and number of lapses in obstructive sleep apnoea patients Samu Kainulainen, Brett Duce, Henri Korkalainen, Arie Oksenberg, Akseli Leino, Erna S. Arnardottir, Antti Kulkas, Sami Myllymaa, Juha Töyräs, Timo Leppänen Eur Respir J, 55 (4) 1901849; 10.1183/13993003.01849-2019
Potential therapeutic targets for lung repair during human ex vivo lung perfusion Aaron Wong, Ricardo Zamel, Jonathan Yeung, Gary D. Bader, Claudia C. Dos Santos, Xiaohui Bai, Yubo Wang, Shaf Keshavjee, Mingyao Liu Eur Respir J, 55 (4) 1902222; 10.1183/13993003.02222-2019
Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis? Jun Fukihara, Yasuhiro Kondoh, Kevin K. Brown, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Yasuhiko Yamano, Atsushi Suzuki, Taiki Furukawa, Hiromitsu Sumikawa, Osamu Takahashi, Takeshi Johkoh, Tomonori Tanaka, Junya Fukuoka, Naozumi Hashimoto, Yoshinori Hasegawa Eur Respir J, 55 (4) 1802465; 10.1183/13993003.02465-2018
Neuropeptide regulation of secretion and inflammation in human airway gland serous cells Derek B. McMahon, Ryan M. Carey, Michael A. Kohanski, Charles C.L. Tong, Peter Papagiannopoulos, Nithin D. Adappa, James N. Palmer, Robert J. Lee Eur Respir J, 55 (4) 1901386; 10.1183/13993003.01386-2019
Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension Catherine E. Simpson, Jenny Y. Chen, Rachel L. Damico, Paul M. Hassoun, Lisa J. Martin, Jun Yang, Melanie Nies, Megan Griffiths, R. Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, Dunbar D. Ivy, William C. Nichols, Allen D. Everett Eur Respir J, 55 (4) 1901761; 10.1183/13993003.01761-2019
Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study Jacob T. Mey, Adithya Hari, Christopher L. Axelrod, Ciarán E. Fealy, Melissa L. Erickson, John P. Kirwan, Raed A. Dweik, Gustavo A. Heresi Eur Respir J, 55 (4) 1901700; 10.1183/13993003.01700-2019
International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria) Amelia Shoemark, Mieke Boon, Christoph Brochhausen, Zuzanna Bukowy-Bieryllo, Maria M. De Santi, Patricia Goggin, Paul Griffin, Richard G. Hegele, Robert A. Hirst, Margaret W. Leigh, Alison Lupton, Karen MacKenney, Heymut Omran, Jean-Claude Pache, Andreia Pinto, Finn P. Reinholt, Josep Schroeder, Panayotis Yiallouros, Estelle Escudier Eur Respir J, 55 (4) 1900725; 10.1183/13993003.00725-2019
Antinuclear antibodies and subclinical interstitial lung disease in community-dwelling adults: the MESA study Elana J. Bernstein, John H.M. Austin, Steven M. Kawut, Ganesh Raghu, Eric A. Hoffman, John D. Newell, Jubal R. Watts, P. Hrudaya Nath, Sushilkumar K. Sonavane, R. Graham Barr, David J. Lederer Eur Respir J, 55 (4) 1902262; 10.1183/13993003.02262-2019
C1-esterase inhibitor treatment for antibody-mediated rejection after lung transplantation: two case reports François Parquin, Elise Cuquemelle, Eve Camps, Jérôme Devaquet, Mathilde Phillips Houllbracq, Edouard Sage, Olivier Brugière, Morgan Le Guen, Elisabeth Longchampt, Stéphanie Malard, Clément Picard, Jean Luc Taupin, Antoine Roux Eur Respir J, 55 (4) 1902027; 10.1183/13993003.02027-2019
Towards selective tuberculosis screening of people in prison in a low-incidence country Gerard de Vries, Sylvia Commandeur, Connie Erkens, Walid Haddad, Niesje Jansen, Peter Kouw, Margreet Kamphorst-Roemer Eur Respir J, 55 (4) 1902209; 10.1183/13993003.02209-2019
Prolidase deficiency: a new genetic cause of combined pulmonary fibrosis and emphysema syndrome in the adult Vincent Cottin, Mouhamad Nasser, Julie Traclet, Lara Chalabreysse, Anne-Sophie Lèbre, Salim Si-Mohamed, François Philit, Françoise Thivolet-Béjui Eur Respir J, 55 (4) 1901952; 10.1183/13993003.01952-2019
The global significance of PRISm: how data from low- and middle-income countries link physiology to inflammation Peter Jackson, Trishul Siddharthan Eur Respir J, 55 (4) 2000184; 10.1183/13993003.00184-2020
The global significance of PRISm: how data from low- and middle-income countries link physiology to inflammation Sara R.A. Wijnant, Lies Lahousse, Guy G. Brusselle Eur Respir J, 55 (4) 2000354; 10.1183/13993003.00354-2020
Managing the supportive care needs of those affected by COVID-19 Sabrina Bajwah, Andrew Wilcock, Richard Towers, Massimo Costantini, Claudia Bausewein, Steffen T. Simon, Elisabeth Bendstrup, Wendy Prentice, Miriam J. Johnson, David C. Currow, Michael Kreuter, Athol U. Wells, Surinder S. Birring, Polly Edmonds, Irene J. Higginson Eur Respir J, 55 (4) 2000815; 10.1183/13993003.00815-2020
Will children reveal their secret? The coronavirus dilemma Luca Cristiani, Enrica Mancino, Luigi Matera, Raffaella Nenna, Alessandra Pierangeli, Carolina Scagnolari, Fabio Midulla Eur Respir J, 55 (4) 2000749; 10.1183/13993003.00749-2020
Sleep disorders and cerebrovascular disease: the long and winding road Jean Louis Pepin, Miguel Angel Martinez-Garcia Eur Respir J, 55 (4) 1901977; 10.1183/13993003.01977-2019
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke Claudio L.A. Bassetti, Winfried Randerath, Luca Vignatelli, Luigi Ferini-Strambi, Anne-Kathrin Brill, Maria R. Bonsignore, Ludger Grote, Poul Jennum, Didier Leys, Jens Minnerup, Lino Nobili, Thomy Tonia, Rebecca Morgan, Joel Kerry, Renata Riha, Walter T. McNicholas, Vasileios Papavasileiou Eur Respir J, 55 (4) 1901104; 10.1183/13993003.01104-2019
Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma Md. Khadem Ali, Richard Y. Kim, Alexandra C. Brown, Jemma R. Mayall, Rafia Karim, James W. Pinkerton, Gang Liu, Kristy L. Martin, Malcolm R. Starkey, Amber L. Pillar, Chantal Donovan, Prabuddha S. Pathinayake, Olivia R. Carroll, Debbie Trinder, Hock L. Tay, Yusef E. Badi, Nazanin Z. Kermani, Yi-Ke Guo, Ritambhara Aryal, Sharon Mumby, Stelios Pavlidis, Ian M. Adcock, Jessica Weaver, Dikaia Xenaki, Brian G. Oliver, Elizabeth G. Holliday, Paul S. Foster, Peter A. Wark, Daniel M. Johnstone, Elizabeth A. Milward, Philip M. Hansbro, Jay C. Horvat Eur Respir J, 55 (4) 1901340; 10.1183/13993003.01340-2019
Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study Elise M.A. Slob, Bronwyn K. Brew, Susanne J.H. Vijverberg, Chantal J.A.R. Kats, Cristina Longo, Mariëlle W. Pijnenburg, Toos C.E.M. van Beijsterveldt, Conor V. Dolan, Meike Bartels, Patrick Magnusson, Paul Lichtenstein, Tong Gong, Gerard H. Koppelman, Catarina Almqvist, Dorret I. Boomsma, Anke H. Maitland-van der Zee Eur Respir J, 55 (4) 1902021; 10.1183/13993003.02021-2019
Epidemiological characteristics of SARS-CoV-2 infections in Shaanxi, China by 8 February 2020 Yang Yao, Yao Tian, Jing Zhou, Xuan Ma, Min Yang, ShengYu Wang Eur Respir J, 55 (4) 2000310; 10.1183/13993003.00310-2020
The clinical dynamics of 18 cases of COVID-19 outside of Wuhan, China Lei Wang, Yong-H Gao, Li-Li Lou, Guo-Jun Zhang Eur Respir J, 55 (4) 2000398; 10.1183/13993003.00398-2020
Celebrating World Tuberculosis Day at the time of COVID-19 Riccardo Alagna, Giorgio Besozzi, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Battista Migliori, Mario Raviglione, Daniela Maria Cirillo Eur Respir J, 55 (4) 2000650; 10.1183/13993003.00650-2020
Clinical efficacy and safety of fluoroquinolone containing regimens in patients with Mycobacterium avium complex pulmonary disease Hadeel Khadawardi, Theodore K. Marras, Mahtab Mehrabi, Sarah K. Brode Eur Respir J, 55 (4) 1901240; 10.1183/13993003.01240-2019
Impact of BAL lymphocytosis and presence of honeycombing on corticosteroid treatment effect in fibrotic hypersensitivity pneumonitis: a retrospective cohort study Laurens J. De Sadeleer, Frederik Hermans, Els De Dycker, Jonas Yserbyt, Johny A. Verschakelen, Eric K. Verbeken, Geert M. Verleden, Stijn E. Verleden, Wim A. Wuyts Eur Respir J, 55 (4) 1901983; 10.1183/13993003.01983-2019
Urgent need of a management plan for survivors of COVID-19 Bartolome Celli, Leonardo M. Fabbri Eur Respir J, 55 (4) 2000764; 10.1183/13993003.00764-2020
The adipose tissue and lung health: like many things in life, the extremes are not good Miguel J. Divo Eur Respir J, 55 (4) 2000107; 10.1183/13993003.00107-2020
Intercostal vessel screening prior to pleural interventions by the respiratory physician: a prospective study of real world practice Eihab O. Bedawi, Ambika Talwar, Maged Hassan, David J. McCracken, Rachelle Asciak, Rachel M. Mercer, Nikolaos I. Kanellakis, Fergus V. Gleeson, Rob J. Hallifax, John M. Wrightson, Najib M. Rahman Eur Respir J, 55 (4) 1902245; 10.1183/13993003.02245-2019
Association between adiposity measures and COPD risk in Chinese adults Jiachen Li, Lu Zhu, Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Yiping Chen, Yonglin Zhou, Ruqin Gao, Junshi Chen, Zhengming Chen, Weihua Cao, Canqing Yu, Liming Li Eur Respir J, 55 (4) 1901899; 10.1183/13993003.01899-2019
a₁ Antitrypsin therapy modulates the neutrophil membrane proteome and secretome Mark P. Murphy, Thomas McEnery, Karen McQuillan, Oisín F. McElvaney, Oliver J. McElvaney, Sarah Landers, Orla Coleman, Anchalin Bussayajirapong, Padraig Hawkins, Michael Henry, Paula Meleady, Emer P. Reeves, Noel G. McElvaney Eur Respir J, 55 (4) 1901678; 10.1183/13993003.01678-2019
New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry Matthias Hagner, Dario L. Frey, Matteo Guerra, A. Susanne Dittrich, Victoria S. Halls, Sabine Wege, Felix J.F. Herth, Carsten Schultz, Marcus A. Mall Eur Respir J, 55 (4) 1902355; 10.1183/13993003.02355-2019
High-resolution computed tomography features of 17 cases of coronavirus disease 2019 in Sichuan province, China Simin Zhang, Huaqiao Li, Songtao Huang, Wei You, Huaiqiang Sun Eur Respir J, 55 (4) 2000334; 10.1183/13993003.00334-2020
Clinical and CT features of early stage patients with COVID-19: a retrospective analysis of imported cases in Shanghai, China Shuyi Yang, Yuxin Shi, Hongzhou Lu, Jianqing Xu, Feng Li, Zhiping Qian, Yebin Jiang, Xinyan Hua, Xueting Ding, Fengxiang Song, Jie Shen, Yang Lu, Fei Shan, Zhiyong Zhang Eur Respir J, 55 (4) 2000407; 10.1183/13993003.00407-2020
The MUC5B promoter risk allele for idiopathic pulmonary fibrosis predisposes to asbestosis Mark G.J.P. Platenburg, Ivo A. Wiertz, Joanne J. van der Vis, Bruno Crestani, Raphael Borie, Philippe Dieude, Caroline Kannengiesser, Jacobus A. Burgers, Jan C. Grutters, Coline H.M. van Moorsel Eur Respir J, 55 (4) 1902361; 10.1183/13993003.02361-2019
The utility and safety of linear endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the paediatric population Haider Al-Najjar, Ronan Breen, George Santis, Omendra Narayan Eur Respir J, 55 (4) 1902277; 10.1183/13993003.02277-2019
Latent tuberculosis screening and treatment among asylum seekers: a mixed-methods study Simone Villa, Luigi Ruffo Codecasa, Marino Faccini, Mirella Maria Pontello, Maurizio Ferrarese, Paola Francesca Castellotti, Sabrina Senatore, Anna Lamberti, Ester Mazzola, Carlo Federico Perno, Daniela Campisi, Matteo Saporiti, Mario Carlo Raviglione Eur Respir J, 55 (4) 2000052; 10.1183/13993003.00052-2020
Latent tuberculosis screening and treatment among asylum seekers: a mixed-methods study Ineke Spruijt, Connie Erkens, Susan van den Hof, Frank Cobelens Eur Respir J, 55 (4) 2000475; 10.1183/13993003.00475-2020
Making simple things complicated using anti-inflammatory reliever therapy Brian Lipworth, Chris RuiWen Kuo, Rory Chan Eur Respir J, 55 (4) 2000267; 10.1183/13993003.00267-2020
Achieving the balance between evidence and simplicity Richard Beasley, Irene Braithwaite, Alex Semprini, Ciléin Kearns, Mark Weatherall, Tim Harrison, Alberto Papi, Ian D. Pavord Eur Respir J, 55 (4) 2000651; 10.1183/13993003.00651-2020