European Respiratory Society Monograph, Vol. 85. 2019
ISBN (electronic): 978-1-84984-109-2
DOI: 10.1183/2312508X.erm8519
This Monograph offers a comprehensive and up-to-date overview of AATD. It covers basic biology, genetics, laboratory diagnostics and the major organ manifestations; describes the clinical presentation of AATD in both adults and children; and features chapters on genetic counselling, patient views and future therapies. The content has been tailored to meet the needs of the physician, who takes care of lung and liver patients in daily practice, and the general practitioner, who is responsible for the medical guidance of these patients.
Preface John R. Hurst Eur Respir Monogr 2019; 85: v | |
Guest Editors
Eur Respir Monogr 2019; 85: vii-viii | |
Introduction Pavel Strnad, Mark Brantly, Robert Bals Eur Respir Monogr 2019; 85: ix-xi | |
List of abbreviations
Eur Respir Monogr 2019; 85: xii | |
Patient view Marion Wilkens, Terry Hannah Eur Respir Monogr 2019; 85: 1-5 | |
Serpinopathies David A. Lomas, James A. Irving, Bibek Gooptu Eur Respir Monogr 2019; 85: 6-26 | |
Genetics and epidemiology of AATD Brian D. Hobbs, Edwin K. Silverman, Michael H. Cho Eur Respir Monogr 2019; 85: 27-38 | |
Laboratory diagnosis of AATD Ilaria Ferrarotti, Stefania Ottaviani Eur Respir Monogr 2019; 85: 39-51 | |
Mechanisms of lung disease in AATD Cesare Saltini, Karina Krotova Eur Respir Monogr 2019; 85: 52-63 | |
Clinical approach to the diagnosis and assessment of AATD Miriam Barrecheguren, Robert Bals, Marc Miravitlles Eur Respir Monogr 2019; 85: 64-77 | |
Treatment of lung disease in patients with AATD Paul Ellis, Asger Dirksen, Alice M. Turner Eur Respir Monogr 2019; 85: 78-92 | |
Mechanisms of liver disease in AATD Pasquale Piccolo, Sergio Attanasio, Nicola Brunetti-Pierri Eur Respir Monogr 2019; 85: 93-104 | |
Clinical approach to paediatric liver disease Jeffrey H. Teckman, Dhiren Patel Eur Respir Monogr 2019; 85: 105-113 | |
Clinical approach to liver disease in adults with AATD Pavel Strnad, Carolin V. Schneider, Virginia Clark Eur Respir Monogr 2019; 85: 114-126 | |
Rare manifestations of AATD Alessandro N. Franciosi, Tomás P. Carroll, Noel G. McElvaney Eur Respir Monogr 2019; 85: 127-142 | |
Genetic counselling Joanna Chorostowska-Wynimko, Aleksandra Jezela-Stanek Eur Respir Monogr 2019; 85: 143-149 | |
Registries: roles, objectives and registry data study outcomes Iris G.M. Schouten, Jan Stolk, Jan Fuge, Marise J. Kasteleyn, Sabina Janciauskiene Eur Respir Monogr 2019; 85: 150-158 | |
Future directions: diagnostic approaches and therapy with AAT Sabina Janciauskiene, Tobias Welte Eur Respir Monogr 2019; 85: 159-178 | |
Case 1 Jeffrey H. Teckman, Dhiren Patel Eur Respir Monogr 2019; 85: 179-183 | |
Case 2 Robert Bals Eur Respir Monogr 2019; 85: 184-186 | |
Case 3 Ali Ataya Eur Respir Monogr 2019; 85: 187-191 | |
Case 4 Carolin V. Schneider, Pavel Strnad Eur Respir Monogr 2019; 85: 192-195 | |