Statins inhibit human lung fibroblast production and activation of MMPs

K. Kamio, X. D. Liu, H. Sugiura, S. Kawasaki, S. Togo, H. J. Kim, X. Wang, Y. Ahn, S. Rennard (Omaha, NE, United States Of America; Wakayama, Japan; Seoul, Republic Of Korea)

Source: Annual Congress 2007 - Inflammatory cell biology
Session: Inflammatory cell biology
Session type: Electronic Poster Discussion
Number: 4077
Disease area: Airway diseases

Congress or journal article abstract

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Kamio, X. D. Liu, H. Sugiura, S. Kawasaki, S. Togo, H. J. Kim, X. Wang, Y. Ahn, S. Rennard (Omaha, NE, United States Of America; Wakayama, Japan; Seoul, Republic Of Korea). Statins inhibit human lung fibroblast production and activation of MMPs. Eur Respir J 2007; 30: Suppl. 51, 4077

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
PP216 – Glucocorticoids exacerbate TGFß1 mediated fibrotic signalling in lung fibroblasts by inhibition of metalloproteinase expression and activity
Source: ERS Lung Science Conference 2021
Year: 2021

VEGF induces ECM synthesis and fibroblast activity in human lung fibroblasts
Source: International Congress 2017 – Towards better treatments for lung disease: experimental pharmacology
Year: 2017

In vitro profibrotic effects of rapamycin on basal or TGF-β1 induced primary human lung fibroblast: ECM production and turnover, migration and differentiation
Source: Annual Congress 2012 - Diffuse parenchymal lung disease I
Year: 2012

Statins inhibit matrix metalloproteinase release from human lung fibroblasts
Source: Eur Respir J 2010; 35: 637-646
Year: 2010



Composition of the cellular matrix, nutrition, and hypoxia modulate the secretion and activation of collagenases and their inhibitors in human lung cells
Source: Eur Respir J 2001; 18: Suppl. 33, 244s
Year: 2001

COX inhibition enhances remodelling processes in human lung fibroblasts
Source: Annual Congress 2010 - Regulation of airway pharmacology
Year: 2010

Effects of endothelin-1 on MAPK activation, IL-6 production and cell proliferation in normal human lung fibroblasts
Source: Eur Respir J 2004; 24: Suppl. 48, 454s
Year: 2004

Statins suppress LPS-induced proinflammatory cytokine production from human bronchial epithelial cells
Source: Annual Congress 2009 - Epithelial cell biology
Year: 2009


Dimethylfumarate reduces growth factor- and cytokine-induced IL-6 release from human lung fibroblasts: role of (NF)-κB
Source: Annual Congress 2008 - Airway cell biology and immunology
Year: 2008

Inhibition of VEGF and MMP-9 production by Pregabalin in human immunocompetent cells in vitro
Source: Virtual Congress 2020 – New insight into the pathogenesis of chronic lung diseases: asthma, COPD and others
Year: 2020

Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation
Source: ERJ Open Res 2016: 00079-2015
Year: 2016



Activated protein C protection in endotoxin-induced lung injury is mediated by lung matrix metalloproteinases activity
Source: Annual Congress 2007 - Miscellaneous lower respiratory tract infections
Year: 2007


Oral Presentation: The functional role of the Frizzled-8 receptor TGF-beta1-induced activation and extracellular matrix production in human lung fibroblasts
Source: Lung Science Conference 2012 - Rebuilding a diseased lung: Repair and regeneration
Year: 2012

Synergistic effect of cysteinyl-leukotrienes and epidermal growth factor on human lung fibroblast mitogenesis
Source: Eur Respir J 2005; 26: Suppl. 49, 340s
Year: 2005

Effects of steroids and b-mimetics on matrix metalloproteinases expression in human lung primary cells
Source: Eur Respir J 2003; 22: Suppl. 45, 453s
Year: 2003

Interleukin-13 induces collagen type-1 expression through matrix metalloproteinase-2 and transforming growth factor-?1 in airway fibroblasts in asthma
Source: Eur Respir J 2014; 43: 464-473
Year: 2013



RB2/p130 gene-enhanced expression downregulates vascular endothelial growth factor expression and inhibits angiogenesis in vivo
Source: Eur Respir J 2002; 20: Suppl. 38, 3s
Year: 2002

Heparins inhibit lung cancer cells proliferation in vitro
Source: Annual Congress 2008 - Biology and prognosis in thoracic oncology
Year: 2008


Inhibitory effect of statins on fibrogenic mediator production from lung cells
Source: Annual Congress 2012 - Diffuse parenchymal lung disease pathogenesis, biomarkers, therapy and new entities
Year: 2012


Matrix metalloproteinase (MMP)-2 production by fibroblasts and mast cells: the role in pulmonary fibrosis
Source: Eur Respir J 2004; 24: Suppl. 48, 455s
Year: 2004