In vitro assessment of triple combination therapy for the most common disease-associated mutation in cystic fibrosis

Han-I Yeh, Tzyh-Chang Hwang

Source: Eur Respir J, 59 (2) 2102380; 10.1183/13993003.02380-2021
Journal Issue: February

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Han-I Yeh, Tzyh-Chang Hwang. In vitro assessment of triple combination therapy for the most common disease-associated mutation in cystic fibrosis. Eur Respir J, 59 (2) 2102380; 10.1183/13993003.02380-2021

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
A novel CFTR mutation found in a Chinese cystic fibrosis patient
Source: Eur Respir J 2005; 26: Suppl. 49, 402s
Year: 2005

Identification of a new cystic fibrosis transmembrane regulator mutation in a severely affected patient
Source: Eur Respir J 2002; 19: 374-376
Year: 2002



Clinical development of triple-combination CFTR modulators for cystic fibrosis patients with one or two F508del alleles
Source: ERJ Open Res, 5 (2) 00082-2019; 10.1183/23120541.00082-2019
Year: 2019



First identified “severe” mutations and extended rearrangements in the CFTR gene in Russian cystic fibrosis patients
Source: Virtual Congress 2020 – Cystic fibrosis
Year: 2020


Genotype specific therapies for cystic fibrosis
Source: Annual Congress 2004 - New approaches to cystic fibrosis: from cells and molecules to novel therapies
Year: 2004

Chronic ataluren (PTC124) treatment of nonsense mutation cystic fibrosis
Source: Eur Respir J 2011; 37: 59-69
Year: 2011



Lumacaftor-Ivacaftor combination therapy in Phe508del homozygous CF patients with end-stage lung disease – preliminary results
Source: International Congress 2017 – Cystic fibrosis: treatments and monitoring
Year: 2017

Evaluation of MRP1-5 gene expression in cystic fibrosis patients homozygous for the ΔF508 mutation
Source: Annual Congress 2003 - Cystic fibrosis: new genes, new controversies
Year: 2003


Cystic fibrosis: prospects for therapy of some class 1 mutations
Source: Annual Congress 2007 - Cystic fibrosis: will the new biology deliver?
Year: 2007


Genotype/phenotype correlation of the G85E mutation in a large cohort of cystic fibrosis patients
Source: Eur Respir J 2004; 23: 679-684
Year: 2004



Genotype-phenotype correlation in cystic fibrosis patients bearing a novel complex allele
Source: Annual Congress 2011 - Cystic fibrosis: clinical and laboratory studies
Year: 2011

Long-term outcomes and clinical worsening in cystic fibrosis patients with at least one residual function mutation
Source: International Congress 2018 – Cystic fibrosis in adults: current research
Year: 2018


CFTR gene mutations detected in Japanese individuals with cystic fibrosis
Source: Eur Respir J 2006; 28: Suppl. 50, 716s
Year: 2006

The cystic fibrosis airway milieu enhances rescue of F508del in a pre-clinical model
Source: Eur Respir J, 52 (6) 1801133; 10.1183/13993003.01133-2018
Year: 2018



Targeting CFTR as a therapy for cystic fibrosis
Source: Lung Science Conference 2010 - Biology of gene-environment interactions in the lung
Year: 2010

Topical application of gentamicin causes a reduction of sweat ion concentration in cystic fibrosis patients carrying nonsense mutations
Source: Eur Respir J 2001; 18: Suppl. 33, 9s
Year: 2001

High morbidity and mortality in cystic fibrosis patients compound heterozygous for 3905insT and ΔF508
Source: Eur Respir J 2001; 17: 1181-1186
Year: 2001



Ataluren in nonsense mutation cystic fibrosis patients not receiving chronic inhaled tobramycin: Evaluation of exacerbations and lung function
Source: International Congress 2016 – Cystic fibrosis: inflammation, microbiology, management and monitoring
Year: 2016


Combination of ENaC and CFTR mutations may predispose to cystic fibrosis-like disease
Source: Eur Respir J 2009; 34: 772
Year: 2009