In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by a1-antitrypsin

Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves

Source: ERJ Open Res, 7 (4) 00234-2021; 10.1183/23120541.00234-2021
Journal Issue: October

Congress or journal article abstractFull text journal articlePDF journal article, handout or slides

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
Padraig Hawkins, Thomas McEnery, Claudie Gabillard-Lefort, David A. Bergin, Bader Alfawaz, Vipatsorn Shutchaidat, Paula Meleady, Michael Henry, Orla Coleman, Mark Murphy, Noel G. McElvaney, Emer P. Reeves. In vitro and in vivo modulation of NADPH oxidase activity and reactive oxygen species production in human neutrophils by a1-antitrypsin. ERJ Open Res, 7 (4) 00234-2021; 10.1183/23120541.00234-2021

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways
Source: Eur Respir J 2004; 23: 496
Year: 2004


Hypoxia and reoxygenation modulate lung epithelial cell glutathione content, oxygen consumption and reactive oxygen species (ROS) production
Source: Eur Respir J 2001; 18: Suppl. 33, 182s
Year: 2001

IL-13 enhances GSNO reductase activity and decreases intracellular S-nitrosothiols in lung epithelial cells
Source: Eur Respir J 2006; 28: Suppl. 50, 103s
Year: 2006

The oxygen free radical-scavenger glutathione prevents the depletion of IL-16 in human CD8 lymphocytes that is caused by tobacco-smoke components in vitro
Source: Annual Congress 2007 - Inflammatory cell biology
Year: 2007


Production of superoxide anions by the NADPH oxidase in mammalian skeletal muscles
Source: Eur Respir J 2001; 18: Suppl. 33, 421s
Year: 2001

Role of complex I and III in the production of reactive oxygen species by mitochondria of peripheral muscle in COPD subjects
Source: Annual Congress 2009 - Gas exchange and exercise in respiratory diseases
Year: 2009

Hypoxia-dependent regulation of non-phagocytic NADPH oxidase NOX4 in the pulmonary vasculature
Source: Eur Respir J 2007; 30: Suppl. 51, 56s
Year: 2007

BALF modulates neutrophil phagocytosis and ROS production in different ways
Source: Annual Congress 2009 - Airway inflammation and host defence
Year: 2009

Xanthine oxidase inhibitors reduce rhinovirus induced IL-8 and GRO-α production in bronchial epithelial cells
Source: Eur Respir J 2007; 30: Suppl. 51, 721s
Year: 2007

Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis
Source: Eur Respir J, 51 (4) 1702021; 10.1183/13993003.02021-2017
Year: 2018



Exhaled H2O2 correlates with the release of reactive oxygen species by blood phagocytes in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 91s
Year: 2002

Altered mitochondrial reactive oxygen species (ROS) production in airway smooth muscle cells of severe asthma.
Source: International Congress 2019 – Novel mechanisms elucidated by translational studies of asthma
Year: 2019

Influence of AECOPD to ROS production in neutrophils
Source: Annual Congress 2011 - COPD: human studies
Year: 2011

Superoxide production by the Nox4 based NAD(P)H oxidase is increased in bronchial biopsies from asthmatic patients. Relationship to lung function
Source: Eur Respir J 2004; 24: Suppl. 48, 683s
Year: 2004

Mitochondrion-derived reactive oxygen species mediate mechanotransduction in A549 cells
Source: Eur Respir J 2006; 28: Suppl. 50, 821s
Year: 2006

Peroxynitrite and superoxide anion chemiluminescence generation during human neutrophil respiratory bursts is reduced by a synergistic combination of budesonide and the SH metabolite of erdosteine
Source: Eur Respir J 2004; 24: Suppl. 48, 218s
Year: 2004

Diamine oxidase activation by diphenhydramine – in vitro but no in vivo effect
Source: Eur Respir J 2003; 22: Suppl. 45, 110s
Year: 2003

Cytokines and reactive oxygen species (ROS) produced by alveolar macrophages (AM) in sarcoidosis
Source: Eur Respir J 2001; 18: Suppl. 33, 68s
Year: 2001

Apocynin reduces reactive oxygen species generation in airways of asthmatics
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Budesonide reduces superoxide and peroxynitrite chemiluminescence during human neutrophil bursts
Source: Eur Respir J 2004; 24: Suppl. 48, 21s
Year: 2004