Alveolar type II cells harbouring SARS-CoV-2 show senescence with a proinflammatory phenotype

K. Paschalaki (London, United Kingdom), K. Evangelou (Athens, Greece), D. Veroutis (Athens, Greece), P. Foukas (Athens, Greece), C. Kittas (Athens, Greece), A. Tzioufas (Athens, Greece), L. De Leval (Lausanne, Switzerland), D. Vassilakos (Athens, Greece), P. Barnes (London, United Kingdom), V. Gorgoulis (Athens, Greece)

Source: Virtual Congress 2021 – Emerging respiratory diseases: state-of-the-art studies of SARS-CoV-2 infection
Session: Emerging respiratory diseases: state-of-the-art studies of SARS-CoV-2 infection
Session type: Oral Presentation
Number: 4312

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
K. Paschalaki (London, United Kingdom), K. Evangelou (Athens, Greece), D. Veroutis (Athens, Greece), P. Foukas (Athens, Greece), C. Kittas (Athens, Greece), A. Tzioufas (Athens, Greece), L. De Leval (Lausanne, Switzerland), D. Vassilakos (Athens, Greece), P. Barnes (London, United Kingdom), V. Gorgoulis (Athens, Greece). Alveolar type II cells harbouring SARS-CoV-2 show senescence with a proinflammatory phenotype. 4312

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Modulation of NOS2 expression in co-cultures of human alveolar epithelial cells type II and alveolar macrophages
Source: Eur Respir J 2001; 18: Suppl. 33, 161s
Year: 2001

Effect of hypoxia on gene regulation and differentiation in alveolar epithelial type II cells
Source: Eur Respir J 2001; 18: Suppl. 33, 162s
Year: 2001

IL-18, a novel Th1 cytokine, is up-regulated in pulmonary tuberculosis: expression and production by alveolar epithelial cells type II
Source: Eur Respir J 2002; 20: Suppl. 38, 213s
Year: 2002

Regulation of human adult primary alveolar type II cell surfactant protein production by epithelial growth factors and pro-inflammatory cytokines
Source: Annual Congress 2009 - Pathological remodelling in chronic lung disease: from epithelial-mesenchymal transition to cellular activation
Year: 2009


PP207 – Targeting p16INK4a in alveolar type 2 cells to induce endogenous lung alveolar regeneration
Source: ERS Lung Science Conference 2021
Year: 2021

Hyperoxia reversibly inhibits the transdifferentiation of alveolar type II (ATII) cells to alveolar type I (ATI) cells
Source: Annual Congress 2005 - Cellular and molecular approaches to lung injury research
Year: 2005


Transcriptomic profiling of alveolar type 2 cells from mice expressing an ILD associated SFTPCI73T mutation supports their role in inflammatory cell recruitment and fibrotic lung remodeling.
Source: International Congress 2018 – Pulmonary fibrosis: from models to patients
Year: 2018

Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

microRNA profiling of murine alveolar epithelial type II cells
Source: Annual Congress 2012 - Molecular biology of pro- and anti-inflammatory responses in the lung
Year: 2012

Increased proliferation of type 2 alveolar epithelial cells in a pneumonectomy model mice with a deletion of p16ink4a gene.
Source: International Congress 2018 – Regenerative and anti-fibrotic approaches
Year: 2018



High amplitude mechanical is pro-inflammatory by reducing IL-10 release from alveolar type II cells
Source: Eur Respir J 2004; 24: Suppl. 48, 107s
Year: 2004

Natural lysophospholipids induce antimycobacterial activity in type II alveolar epithelial cells
Source: Annual Congress 2010 - Scientific advances in tuberculosis
Year: 2010

High concentrations of VEGF reduce stretch-induced apoptosis of alveolar type II cells
Source: Annual Congress 2009 - Highlighting the epithelial cell in lung disease: from COPD to cancer to acute lung injury
Year: 2009


GRX1 enhances wound repair of alveolar epithelial type II cells in vitro
Source: Annual Congress 2009 - Crossing the line: alveolo-capillary barrier control in acute lung injury
Year: 2009

Proliferation of alveolar type II pneumocytes is stimulated by Jagged-1 in vitro
Source: Annual Congress 2012 - Fibrogenesis between epithelial injury and fibroblast proliferation
Year: 2012


Fgfr2b signaling in Alveolar Epithelial type II cells following pneumonectomy in mice
Source: International Congress 2017 – Molecular pathways in lung development
Year: 2017

Protein S inhibits the secretion of inflammatory cytokines from alveolar epithelial cells
Source: Annual Congress 2008 - Structural remodelling in COPD
Year: 2008

RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation
Source: Virtual Congress 2020 – Elucidating the mechanisms underlying lung repair and exploring therapeutic strategies in vitro
Year: 2020




PP126 – RANKL contributes to lung tissue repair via promoting type II epithelial cell proliferation
Source: ERS Lung Science Conference 2021
Year: 2021

Modulation of surfactant metabolism in type II cells from injured lungs by TNF-α and IL-10
Source: Eur Respir J 2003; 22: Suppl. 45, 78s
Year: 2003