Late Breaking Abstract - Enhanced IL-33 response in differentiated human TH2 cells carrying the IL-1RL1 asthma risk genotype

A. Saikumar Jayalatha (Groningen , Netherlands), L. Hesse (Groningen , Netherlands), M. Ketelaar (Groningen , Netherlands), M. Van Den Berge (Groningen , Netherlands), V. Gurvey (Groningen , Netherlands), G. Koppelman (Groningen , Netherlands), M. Nawijn (Groningen , Netherlands)

Source: Virtual Congress 2021 – Asthma and COPD meets COVID-19: new diagnostic tools and results from clinical trials

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Saikumar Jayalatha (Groningen , Netherlands), L. Hesse (Groningen , Netherlands), M. Ketelaar (Groningen , Netherlands), M. Van Den Berge (Groningen , Netherlands), V. Gurvey (Groningen , Netherlands), G. Koppelman (Groningen , Netherlands), M. Nawijn (Groningen , Netherlands). Late Breaking Abstract - Enhanced IL-33 response in differentiated human TH2 cells carrying the IL-1RL1 asthma risk genotype. 2530

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Late Breaking Abstract - Transcriptional response to RSV in asthma primary bronchial epithelial cells: are the basal cells responsible for the reduced NF-kB response?
Source: Virtual Congress 2021 – Mechanistic pathways in chronic and new lung diseases
Year: 2021



Late Breaking Abstract: A role for IL-25 as ‘initiator‘ in Th2 driven inflammation is restricted to IL-5 high Th2 patients
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010

Late Breaking Abstract - GATA-3 in lung CD4+T cells drives Interleukin-10 deficiency-induced lung inflammation in asthma
Source: Virtual Congress 2020 – New insights into asthma immunology: in mouse and men
Year: 2020




CD38 gene-modified dendritic cells inhibit murine asthma development through increasing IL-12 production and promoting Th1 cell differentiation
Source: International Congress 2016 – Immune responses in the lung
Year: 2016

Late Breaking Abstract - Benralizumab treatment reduces the high-affinity IgE receptor on plasmacytoid dendritic cells in patients with severe asthma
Source: International Congress 2019 – Precision meets immunology in treatment of airway diseases
Year: 2019



Interferon-gamma (IFN-γ) alters the expression of IP-10 and IL-18 in human aveolar epithelial cells type II. Possible role in the reinforcement of Th1-dominated lung inflammation
Source: Eur Respir J 2001; 18: Suppl. 33, 521s
Year: 2001

Modified mRNA encoding Foxp3 protects against allergic asthma in mice by rebalancing T helper cell responses through an IL-23 / IL-17A-dependent mechanism
Source: Annual Congress 2012 - Treating childhood asthma
Year: 2012

IL-33 and TSLP gene expression are increased in response to human rhinovirus 1B in HDM-treated murine bone marrow-derived macrophages
Source: International Congress 2014 – New insights into monocyte and macrophage biology
Year: 2014

Low number of regulatory T cells in bronchial asthma: association with inflammatory cytokines
Source: Annual Congress 2009 - Infections, immunity and inflammation
Year: 2009



Association between T-regulatory cells blood content and Th2 cells activity in asthma
Source: Annual Congress 2013 –Asthma: new mechanisms and markers
Year: 2013

Late Breaking Abstract: IL-17 inhibits IL-23 release during airway inflammation
Source: Annual Congress 2010 - Lung cell biology and immunology
Year: 2010


Macrophages induce an allergen-specific and long-term suppression in a mouse asthma model
Source: Eur Respir J 2005; 26: 1040-1046
Year: 2005



MiR-1165-3p downregulated in Th2 cells inhibits Th2 differentiation in allergic asthma by targeting PPM1A
Source: International Congress 2019 – Identification of new targets and therapeutic strategies for lung disease
Year: 2019

Late Breaking Abstract - Bedaquiline enhances receptor phagocytosis and decreases IL1b production in human pro-inflammatory macrophages
Source: Virtual Congress 2021 – Immunological and molecular characterisation of tuberculosis disease and infection
Year: 2021


Activin-A is a critical inducer of human CD4+ICOS+IL-10-secreting regulatory T cells that suppress allergen-driven T cell responses in vitro and experimental asthma in a humanized mouse model in vivo
Source: International Congress 2015 – Animal studies of asthma and other inflammatory conditions
Year: 2015

Increase of both blood CXCR3+ and CCR4+ helper T cells associated with severity of asthma
Source: Annual Congress 2005 - Inflammation and remodelling in allergy and asthma
Year: 2005


Normal T cell expressed and secreted (RANTES): a marker of asthmatic inflammation?
Source: Eur Respir J 2004; 24: Suppl. 48, 163s
Year: 2004

Late Breaking Abstract - IL-33 drives influenza-induced exacerbations of asthma by halting anti-viral and Th1 responses
Source: International Congress 2017 – Animal models of asthma and allergies
Year: 2017

IL-8 and TSLP production as markers of bronchial epithelial cell activation in IL-17A mediated airway inflammation in COPD: Role of tiotropium
Source: Annual Congress 2013 –New insights into epigenetic mechanisms in the lung
Year: 2013

Peripheral blood Th9 cells and IL-9 level in asthma patients with early and dual asthmatic response
Source: International Congress 2015 – Novel mechanisms and treatments in allergy and asthma
Year: 2015