Drug-drug interaction study between zamicastat and furosemide in healthy subjects

A. Santos (Coronado (S. Mamede e S. Romão) - Porto, Portugal), L. Magalhães (Coronado (S. Mamede e S. Romão) - Porto, Portugal), A. Guimarães (Coronado (S. Mamede e S. Romão) - Porto, Portugal), H. Gama (Coronado (S. Mamede e S. Romão) - Porto, Portugal), P. Magalhaes (Coronado (S. Mamede e S. Romão) - Porto, Portugal), P. Soares-Da-Silva (Porto, Portugal)

Source: Virtual Congress 2021 – Therapy of pulmonary hypertension
Session: Therapy of pulmonary hypertension
Session type: E-poster
Number: 1930

Congress or journal article abstractE-poster

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Santos (Coronado (S. Mamede e S. Romão) - Porto, Portugal), L. Magalhães (Coronado (S. Mamede e S. Romão) - Porto, Portugal), A. Guimarães (Coronado (S. Mamede e S. Romão) - Porto, Portugal), H. Gama (Coronado (S. Mamede e S. Romão) - Porto, Portugal), P. Magalhaes (Coronado (S. Mamede e S. Romão) - Porto, Portugal), P. Soares-Da-Silva (Porto, Portugal). Drug-drug interaction study between zamicastat and furosemide in healthy subjects. 1930

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Drug-drug interaction study between zamicastat and sildenafil in healthy subjects
Source: Virtual Congress 2020 – Epidemiology and treatment of pulmonary arterial hypertension
Year: 2020


An overview of drug-drug interaction studies conducted with treprostinil
Source: Annual Congress 2009 - Pulmonary vascular diseases
Year: 2009

The effect of fluconazole on the pharmacokinetics of ensifentrine in healthy individuals
Source: Virtual Congress 2021 – Pharmacology of airway diseases: clinical and laboratory studies
Year: 2021


No relevant drug-drug interaction between inhaled NVA237 and oral cimetidine
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012


Pharmacokinetic characteristics of roflumilast administered in gradually increasing doses of 500μg to 1000μg are dose-linear in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 108s
Year: 2002

Roflumilast and sildenafil in healthy male volunteers: Single-dose pharmacokinetic interactions, safety and tolerability
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics II
Year: 2010

Safety, pharmacokinetics, and pharmacodynamics of TD-8236, an inhaled pan-JAK inhibitor, following single- and multiple-ascending doses in healthy volunteers and mild asthmatics
Source: Virtual Congress 2021 – Clinical trials in airway diseases: novel treatments and new evidence
Year: 2021



Lack of relevant pharmacokinetic and pharmacodynamic interactions between the new dual endothelin receptor antagonist macitentan and warfarin in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


A comparative study on systemic pharmacodynamic effects of two HFA formulations of salmeterol xinafoate, in healthy subjects
Source: Annual Congress 2010 - Drug delivery and pharmacokinetics I
Year: 2010


Single-dose, first-in-human study of AMG 317: safety and pharmacokinetics in healthy and asthmatic adults
Source: Annual Congress 2008 - New treatments for asthma
Year: 2008

Glycopyrronium does not affect QT interval in healthy subjects: A randomized, 3-period cross-over, placebo- and positive-controlled study
Source: Annual Congress 2013 –LAMA, LABA, ICS and their combinations for the treatment of asthma and COPD
Year: 2013


No significant clinical drug-drug interaction potential with indacaterol
Source: Annual Congress 2011 - Drug delivery and pharmacokinetics II
Year: 2011


Multiple-dose study of AMG 853 in healthy adults: Safety and pharmacokinetics
Source: Annual Congress 2010 - New treatments for asthma and COPD
Year: 2010

Tolerability and pharmacokinetics of inhaled bimosiamose in healthy human volunteers
Source: Eur Respir J 2006; 28: Suppl. 50, 332s
Year: 2006

Urinal expression profile of miRNAs after smoking cessation in healthy subjects: a pilot study
Source: International Congress 2017 – Smoking and molecular findings
Year: 2017



A randomised placebo controlled trial to evaluate the effects of butamirate and dextromethorphan on capsaicin induced cough in healthy volunteers
Source: Annual Congress 2013 –Novel drugs and biomarkers in respiratory medicine
Year: 2013

Design and implementation of a multi-part, flexible protocol to assess the tolerability and pharmacodynamic effects of PUR118 in healthy subjects and COPD patients
Source: Annual Congress 2012 - The best of pharmacology treatments of airway diseases: new devices and drugs
Year: 2012


Pharmacokinetics and pharmacodynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects
Source: Eur Respir J 2002; 20: Suppl. 38, 110s
Year: 2002

Lack of relevant pharmacokinetic interactions between the new dual endothelin receptor antagonist macitentan and sildenafil in healthy subjects
Source: Annual Congress 2012 - Pulmonary circulation: clinical PAH, registries and treatments
Year: 2012


Multiple-dose study of AMG 317 in adults with asthma: pharmacokinetics and safety
Source: Annual Congress 2008 - New treatments for asthma
Year: 2008