Late Breaking Abstract - The respiratory tract of patients with antibody deficiency on immunoglobulin replacement is characterised by inflammation and dysbiosis despite adequate levels of sputum IgG

A. Schnell (Bern, Switzerland), D. Lowe (London, United Kingdom), S. Graeter (Bern, Switzerland), M. Davrandi (London, United Kingdom), S. Burns (London, United Kingdom), A. Schaub (Bern, Switzerland), M. Saxenhofer (Bern, Switzerland), M. Hauswald (Marburg, Germany), C. Witte (Marburg, Germany), C. Leboreiro (London, United Kingdom), F. Moreira (London, United Kingdom), I. Irincheeva (Bern, Switzerland), I. Schulze (Bern, Switzerland), C. Vonarburg (Bern, Switzerland), A. Feussner (Marburg, Germany)

Source: Virtual Congress 2021 – Bronchiectasis heterogeneity: assessing the endotypes
Session: Bronchiectasis heterogeneity: assessing the endotypes
Session type: Oral Presentation
Number: 1315

Congress or journal article abstractWebcastSlide presentation

Rating: 0
You must login to grade this presentation.

Share or cite this content

Citations should be made in the following way:
A. Schnell (Bern, Switzerland), D. Lowe (London, United Kingdom), S. Graeter (Bern, Switzerland), M. Davrandi (London, United Kingdom), S. Burns (London, United Kingdom), A. Schaub (Bern, Switzerland), M. Saxenhofer (Bern, Switzerland), M. Hauswald (Marburg, Germany), C. Witte (Marburg, Germany), C. Leboreiro (London, United Kingdom), F. Moreira (London, United Kingdom), I. Irincheeva (Bern, Switzerland), I. Schulze (Bern, Switzerland), C. Vonarburg (Bern, Switzerland), A. Feussner (Marburg, Germany). Late Breaking Abstract - The respiratory tract of patients with antibody deficiency on immunoglobulin replacement is characterised by inflammation and dysbiosis despite adequate levels of sputum IgG. 1315

You must login to share this Presentation/Article on Twitter, Facebook, LinkedIn or by email.

Member's Comments

No comment yet.
You must Login to comment this presentation.


Related content which might interest you:
Pattern of bronchial colonization and inflammatory response in patients with bronchiectasis and immunoglobulin deficiency (Igdef)
Source: Eur Respir J 2001; 18: Suppl. 33, 466s
Year: 2001

IgG subclasses in association with respiratory diseases - infection as a consequence or cause of deficiency?
Source: Eur Respir J 2001; 18: Suppl. 33, 543s
Year: 2001

Treatment with intravenous immunoglobulin (IVG) in children with humoral immune deficiencies and recurrent respiratory tract infections
Source: Eur Respir J 2001; 18: Suppl. 33, 511s
Year: 2001

Recurrent respiratory infections (RRIs): when may be present in children with immunoglobulin deficiency?
Source: Eur Respir J 2001; 18: Suppl. 33, 235s
Year: 2001

Serum immunoglobulin level is a useful marker for the risk of opportunistic infection in steroid dependent patients with chronic inflammatory airway diseases
Source: Annual Congress 2011 - Biomarkers and exacerbations of asthma and COPD
Year: 2011

Serum level of specific IgG antibody for aspergillus and its association with severity of asthma in asthmatic children
Source: Annual Congress 2012 - Clinical and diagnostic markers and management of paediatric allergic diseases
Year: 2012

Antibody deficiency in adults with recurrent respiratory tract infections
Source: Eur Respir J 2001; 18: Suppl. 33, 106s
Year: 2001

Recurrent respiratory tract infections in the preschoolers and IgG3 deficiency
Source: Annual Congress 2011 - Paediatric respiratory infection: signs, symptoms and sequelae
Year: 2011


IgG immunoglobulin levels and the frequency of respiratory infections in patients with chronic obstructive pulmonary disease (COPD)
Source: Eur Respir J 2002; 20: Suppl. 38, 543s
Year: 2002

Determining early response to anti-IL5/IL5R monoclonal antibodies in severe eosinophilic asthma
Source: Virtual Congress 2020 – Monoclonal antibodies; randomised controlled trials and real-world studies in asthma
Year: 2020


High prevalence of serum IgA antibodies against gliadin in patients with interstitial lung diseases confirmed by immunoblotting
Source: Eur Respir J 2003; 22: Suppl. 45, 227s
Year: 2003

Immunoglobulin G subclass deficiency in adult patients with chronic obstructive lung diseases
Source: International Congress 2014 – Interventions and other therapeutic approaches in respiratory infections
Year: 2014


Increased total, secretory and NTHi-specific IgA in the COPD airway
Source: International Congress 2015 – The relevance of diagnostic and monitoring tools in clinical practice
Year: 2015

Immunoglobulin treatment with recommended dosages do not prevent deterioration in lung function in primary hypogammaglobulinemia
Source: Eur Respir J 2006; 28: Suppl. 50, 557s
Year: 2006

Pulmonary immunoglobulin E levels and the response to anti-immunoglobulin E antibody therapy in paediatric severe therapy resistant asthma
Source: Annual Congress 2012 - Treating childhood asthma
Year: 2012




Change of lung function in severe eosinophilic asthma undergoing treatment with anti-interleukin-5 monoclonal antibody
Source: International Congress 2018 – Role of IgE and interleukin (IL)-5 in Th2-cell signatures
Year: 2018

Economic burden of severe asthma associated with blood eosinophil elevation before introduction of Monoclonal Antibody Therapy
Source: International Congress 2019 – Asthma and allergies worldwide
Year: 2019


Relationship of serum immunoglobulines and IgG subclasses in previously healthy adult patients with community acquired pneumonia
Source: Annual Congress 2009 - Mechanisms of infection: what's new?
Year: 2009


Altered IgG but normal IgA responses to pneumococcal proteins in lung fluid and serum in HIV infected adults
Source: Annual Congress 2010 - Mechanisms of respiratory infections
Year: 2010


The content of IgE and circulating immune complexes (CIC) in pregnant women with exacerbation of chronic simple bronchitis due to cytomegalovirus infection
Source: Virtual Congress 2020 – Novel immunopathological mechanisms of lung disease: knowledge from translational studies
Year: 2020